Evaluation of 12 Commercial Tests and the Complement Fixation Test for
            <i>Mycoplasma pneumoniae</i>
            -Specific Immunoglobulin G (IgG) and IgM Antibodies, with PCR Used as the “Gold Standard”

Beersma, Matthias F. C.; Dirven, Kristien; Dam, Alje P. van; Templeton, Kate; Claas, Eric C. J.; Goossens, Herman

doi:10.1128/jcm.43.5.2277-2285.2005

Cited by 188 publications

(158 citation statements)

References 33 publications

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“…In addition, a specific postmarketing surveillance of CAM [12,13], which is a macrolide antibiotic recommended as an empiric treatment for outpatients with suspected atypical pneumonia in the JRS Guidelines [9] [14]. We should consider using ImmunoCard ® in combination with paired serum specimens or other diagnostic techniques to make a definitive diagnosis of M. pneumoniae infection.…”

Section: (4) Discussionmentioning

confidence: 99%

Efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: Postmarketing surveillance in Japan

Izumikawa

Watanabe

Miyashita

et al. 2014

Journal of Infection and Chemotherapy

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Section: (4) Discussionmentioning

confidence: 99%

Efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: Postmarketing surveillance in Japan

Izumikawa

Watanabe

Miyashita

et al. 2014

Journal of Infection and Chemotherapy

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“…All of the culture and IgM ELISA test positive patients were PCR-positive, too. The PCR method is more sensitive and is the gold standard currently being used for diagnosis of this organism in some laboratories (13).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, clinical features, and laboratory detection of Mycoplasma pneumoniae infection in East Azerbaijan, Iran

Khanshour¹,

Conant²,

Juras³

et al. 2013

Turk J Med Sci

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Examining and measuring levels of suspended sediments of water column is a common application of close range remote sensing, because the technology offers an efficient and economical means of studying water quality problems. The aim of this experiment was to use close range remote sensing to determine the effect of increasing suspended sediment concentration containing different levels of organic matter on algal spectral patterns. The experiment was conducted in a small room with a 65-l volume water container. A Spectron Engineering SE-590 spectroradiometer with a 15 • optic was used to take the radiant measurements. The results indicate that the suspended sediment causes increasing spectral response in surface waters. The organic matter content of the suspended sediment has an effect on the spectral reflectance. Therefore, the organic content of the soil present in the water body can be estimated and this property of sediment can help us to recognize the sediment type present in the various layers of the water.

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“…Few commercial serologic assays have been shown to have appropriate sensitivity and specificity. 3 Conversely, polymerase chain reaction may overestimate the incidence of MP and cost considerations limit its use. These factors frequently limit or delay diagnosis and introduce arbitrariness to therapeutic decisions.…”

mentioning

confidence: 99%

Treatment of Mycoplasma pneumoniae in Pediatric Lower Respiratory Infection

et al. 2014

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In this issue of Pediatrics, Biondi et al 1 present a rigorous systematic review and meta-analysis of the literature on the use of antibiotics to treat community-acquired (CA) lower respiratory infections (LRIs) secondary to Mycoplasma pneumoniae (MP). Consistent with previous studies, but on a larger scale, the evidence is deemed insufficient to support or refute such treatments for MP.The following comments, although largely addressed in the article, are intended to highlight the caution that is required on the part of the reader when attempting to implement these conclusions to everyday practice. In particular, we must point out that lack of evidence of efficacy is not evidence of inefficacy when addressing current treatment paradigms. The problems of this and previous studies lie in the lack of uniformity of diagnostic methods, complicated by the fact that mixed infections with other microorganisms often go undiagnosed and contaminate any analysis of treatment efficacy. The small number of studies and their heterogeneity add to our inability to conclude either way, and therefore statements about results of MP-oriented antibiotic treatment are difficult to substantiate, particularly when applied to individual cases.MP is a common cause of CA LRI, particularly in school-aged children and adolescents. It is responsible for at least 40% of cases of CA pneumonia (CAP) and as many as 18% of cases requiring hospitalization in children. 2The diagnosis of MP infection is difficult and nonuniform, and serology and nucleic acid amplification (polymerase chain reaction) are mostly used. Few commercial serologic assays have been shown to have appropriate sensitivity and specificity.3 Conversely, polymerase chain reaction may overestimate the incidence of MP and cost considerations limit its use. These factors frequently limit or delay diagnosis and introduce arbitrariness to therapeutic decisions.Even when the diagnosis is made, there is evidence that MP infections are often mixed; Korppi et al 4 reported .50% of MP CAP to be mixed infections, with Streptococcus pneumoniae identified in two-thirds of cases. MP may precede and intensify subsequent infections with various respiratory viruses and bacteria.5 Such data raise the question of how statements on efficacy of therapies for MP can be made when there is not even the knowledge of which organisms are being targeted.Patients with MP infections mostly recover spontaneously, and it is difficult to assess how intervention and the timing thereof within the course of the infection can be factored in when studying the results of therapies. In human studies, antibiotics have been shown to shorten the clinical course of MP infection, 6 but at the same time carriage of organisms in the upper respiratory tract may not be eliminated.7 It is therefore difficult to assess the effect of medication when organism eradication is not achieved, and thus the response of MP, unlike bacterial infections, is inherently more subtle and variable. Biondi

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Evaluation of 12 Commercial Tests and the Complement Fixation Test for Mycoplasma pneumoniae -Specific Immunoglobulin G (IgG) and IgM Antibodies, with PCR Used as the “Gold Standard”

Cited by 188 publications

References 33 publications

Efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: Postmarketing surveillance in Japan

Efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: Postmarketing surveillance in Japan

Epidemiology, clinical features, and laboratory detection of Mycoplasma pneumoniae infection in East Azerbaijan, Iran

Treatment of Mycoplasma pneumoniae in Pediatric Lower Respiratory Infection

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