Evaluation method of the degree of red blood cell aggregation considering ultrasonic propagation attenuation by analyzing ultrasonic backscattering properties

Nagasawa, Kanta; Fukase, Akiyo; Mori, Shiro; Arakawa, Mototaka; Yashiro, Satoshi; Ishigaki, Yasushi; Kanai, Hiroshi

doi:10.1007/s10396-020-01065-z

Cited by 8 publications

(14 citation statements)

References 16 publications

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“…We have been studying methods for evaluating the size of red blood cell (RBC) aggregates by analyzing the scattering power spectrum obtained via ultrasonic backscattering measurements of RBCs [19][20][21][22][23][24]. Notably, the backscattering power obtained from a single sphere significantly depends on the frequency for each aggregate size [25], and the larger the diameter of a sphere, the smaller the slope of the frequency dependence of the power spectrum.…”

Section: Introductionmentioning

confidence: 99%

“…The size of RBC aggregates is estimated by fitting the slope of the measured power spectrum to that of a single scattering sphere's theoretically obtained scattering characteristics. To extract the scattering property from RBC aggregates, the power spectrum obtained from the vascular lumen is normalized by that obtained from the posterior wall of a blood vessel [20][21][22][23] or compared with the reference scattering spectrum [24]. To estimate the size of RBC aggregates with greater accuracy, the attenuation coefficients of the skin and blood must be measured, and the attenuation property differences between the two power spectra must be corrected [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

“…To extract the scattering property from RBC aggregates, the power spectrum obtained from the vascular lumen is normalized by that obtained from the posterior wall of a blood vessel [20][21][22][23] or compared with the reference scattering spectrum [24]. To estimate the size of RBC aggregates with greater accuracy, the attenuation coefficients of the skin and blood must be measured, and the attenuation property differences between the two power spectra must be corrected [22][23][24]. To measure the attenuation coefficient, power spectra at only two different depths were used.…”

Section: Introductionmentioning

confidence: 99%

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In vivo measurement of attenuation coefficient of blood in a dorsal hand vein in a frequency range of 10–45 MHz: A preliminary study

Arakawa

Higashiyama²,

Mori³

et al. 2023

Front. Phys.

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In this study, the attenuation coefficient of blood was measured in vivo in the frequency range of 10–45 MHz. A procedure to correct the distribution of sound pressure in the measurements was discussed. Further, in vivo measurements were applied on the dorsal hand vein of four healthy subjects at rest and during avascularization. As a preliminary result, less variation of the measured attenuation coefficients was achieved by the proposed method. The comparable results of the inclination of the attenuation coefficients were obtained at rest and during avascularization. Furthermore, the attenuation coefficients during avascularization were markedly higher than those at rest, reflecting the degree of red blood cell aggregation promoted by avascularization. This method may aid in the non-invasive evaluation of blood properties reflecting the degree of red blood cell aggregation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vivo measurement of attenuation coefficient of blood in a dorsal hand vein in a frequency range of 10–45 MHz: A preliminary study

Arakawa

Higashiyama²,

Mori³

et al. 2023

Front. Phys.

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“…We have studied a noninvasive and quantitative method for measuring blood properties. [28][29][30][31][32][33][34][35][36][37] Saito et al assumed that RBCs aggregate as a single-sphere scatterer and estimated the size from the scattering characteristics extracted by normalizing the power spectrum measured from the vessel lumen with that from the rear wall using a focused ultrasound transducer. [28][29][30][31][32] We also examined the relationship between RBC aggregation using ultrasound and blood glucose level.…”

Section: Introductionmentioning

confidence: 99%

“…[28][29][30][31][32][33][34][35][36][37] Saito et al assumed that RBCs aggregate as a single-sphere scatterer and estimated the size from the scattering characteristics extracted by normalizing the power spectrum measured from the vessel lumen with that from the rear wall using a focused ultrasound transducer. [28][29][30][31][32] We also examined the relationship between RBC aggregation using ultrasound and blood glucose level. Sakaki et al compared the blood glucose levels with the parameters determined from changes in the scattering power spectra of the echoes from the vascular lumen before and after avascularization.…”

Section: Introductionmentioning

confidence: 99%

Estimation of aggregate size of red blood cell by introducing reference power spectrum measured for hemispherical ultrafine wire

Higashiyama

Mori

Arakawa

et al. 2022

Jpn. J. Appl. Phys.

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Noninvasive measurement of the degree of red blood cell (RBC) aggregation is useful for evaluating blood properties. In the present paper, we proposed a method to estimate the size of RBC aggregates without using the power spectrum of the posterior wall by introducing a reference scattering spectrum. The reference power spectra were calculated using the power spectrum measured for an ultrafine wire with a hemispherical tip. They were applied to the size estimation of microparticles simulating RBC aggregates. The estimated sizes were close to the true values, which shows that the calculated reference power spectra were suitable for accurate size estimation. The proposed method was also applied to in vivo measurements, and the estimated sizes between at rest and in RBCs aggregated by avascularization were successfully differentiated. This demonstrates that the proposed method will be useful for estimating the size of RBC aggregates.

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Contrast analysis in ultrafast ultrasound blood flow imaging of jugular vein

et al. 2023

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Purpose The contrasts of flowing blood in in vitro experiments using porcine blood and in vivo measurements of human jugular veins were analyzed to demonstrate that the hemorheological property was dependent on the shear rate. Methods Blood samples (45% hematocrit) suspended in saline or plasma were compared with examine the difference in viscoelasticity. Ultrafast plane-wave imaging at an ultrasonic center frequency of 7.5 MHz was performed on different steady flows in a graphite-agar phantom. Also, in vivo measurement was performed in young, healthy subjects and patients with diabetes. A spatiotemporal matrix of beamformed radio-frequency data was used for the singular value decomposition (SVD) clutter filter. The clutter-filtered B-mode image was calculated as the amplitude envelope normalized at the first frame in the diastolic phase to evaluate contrast. The shear rate was estimated as the velocity gradient perpendicular to the lateral axis. Results Although nonaggregated erythrocytes at a high shear rate exhibited a low echogenicity, the echogenicity in the plasma sample overall increased due to erythrocyte aggregation at a low shear rate. In addition, the frequency of detection of specular components, defined as components beyond twice the standard deviation of a contrast map obtained from a clutter-filtered B-mode image, increased in the porcine blood at a high shear rate and the venous blood in healthy subjects versus patients with diabetes. Conclusion The possibility of characterizing hemorheological properties dependent on the shear rate and diabetes condition was indicated using ultrafast plane-wave imaging with an SVD-based clutter filter.

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Evaluation method of the degree of red blood cell aggregation considering ultrasonic propagation attenuation by analyzing ultrasonic backscattering properties

Cited by 8 publications

References 16 publications

In vivo measurement of attenuation coefficient of blood in a dorsal hand vein in a frequency range of 10–45 MHz: A preliminary study

In vivo measurement of attenuation coefficient of blood in a dorsal hand vein in a frequency range of 10–45 MHz: A preliminary study

Estimation of aggregate size of red blood cell by introducing reference power spectrum measured for hemispherical ultrafine wire

Contrast analysis in ultrafast ultrasound blood flow imaging of jugular vein

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