Evaluation macroscopically scar of the string bean and the hull of the caesalpinia ferrea (tul.) Martius (“jucá”) on the cutaneous wounds of the asinines (equus asinus)

Oliveira, Ilanna Vanessa Pristo de Medeiros; Dias, Regina Valéria da Cunha; Calado, Eraldo Barbosa; Lucena, Rivaldo Bruno Medeiros de; Costa, Antônio Leandro Ferreira da; Sakamoto, Sidney Miyoshi; Pimentel, Muriel Magda Lustosa

doi:10.21708/avb.2014.8.2.3578

Cited by 3 publications

(3 citation statements)

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“…In the Amazon, there are approximately 25–30,000 species, but less than 1% of the Brazilian plant species have been was investigated from the chemical and pharmacological point of view (Yunes, Pedrosa & Cechinel Filho, 2001; Araújo et al, 2014; Oliveira et al, 2014; Kobayashi et al, 2015; Dutra et al, 2016). …”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of silver nanoparticles using Caesalpinia ferrea (Tul.) Martius extract: physicochemical characterization, antifungal activity and cytotoxicity

Soares

Corrêa

Stroppa

et al. 2018

PeerJ

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BackgroundGreen synthesis is an ecological technique for the production of well characterized metallic nanoparticles using plants. This study investigated the synthesis of silver nanoparticles (AgNPs) using a Caesalpinia ferrea seed extract as a reducing agent.MethodsThe formation of AgNPs was identified by instrumental analysis, including ultraviolet–visible (UV–Vis) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD) of the AgNPs, and surface-enhanced Raman scattering (SERS) spectra of rhodamine-6G (R6G). We studied the physicochemical characterization of AgNPs, evaluated them as an antifungal agent against Candida albicans, Candida kruzei, Candida glabrata and Candida guilliermondii, and estimated their minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values. Lastly, this study evaluated the cytotoxicity of the AgNPs in murine L929 fibroblasts cells using an MTT assay.ResultsThe UV–Vis spectroscopy, SERS, SEM and XRD results confirmed the rapid formation of spheroidal 30–50 nm AgNPs. The MIC and MFC values indicated the antifungal potential of AgNPs against most of the fungi studied and high cell viability in murine L929 fibroblasts. In addition, this study demonstrated that C. ferrea seed extracts may be used for the green synthesis of AgNPs at room temperature for the treatment of candidiasis.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis of silver nanoparticles using Caesalpinia ferrea (Tul.) Martius extract: physicochemical characterization, antifungal activity and cytotoxicity

Soares

Corrêa

Stroppa

et al. 2018

PeerJ

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“…Extensive research has been conducted on Jucá, focusing on its diverse biological properties, including anti-inflammatory, analgesic, anticancer, antioxidant, antiulcer, and antimicrobial activities [16,[18][19][20][21][22][23]. Phytochemical studies of Jucá have revealed the presence of phenolic compounds, tannins, and flavonoids [22,24].…”

Section: Introductionmentioning

confidence: 99%

Antiplasmodial Activity of Hydroalcoholic Extract from Jucá (Libidibia ferrea) Pods

et al. 2023

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Malaria is an infectious and parasitic disease caused by protozoa of the genus Plasmodium, which affects millions of people in tropical and subtropical areas. Recently, there have been multiple reports of drug resistance in Plasmodium populations, leading to the search for potential new active compounds against the parasite. Thus, we aimed to evaluate the in vitro antiplasmodial activity and cytotoxicity of the hydroalcoholic extract of Jucá (Libidibia ferrea) in serial concentrations. Jucá was used in the form of a freeze-dried hydroalcoholic extract. For the cytotoxicity assay, the(3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) method with the WI-26VA4 human cell line was used. For the antiplasmodial activity, Plasmodium falciparum synchronized cultures were treated with serial concentrations (0.2 to 50 μg/mL) of the Jucá extract. In terms of the chemical composition of the Jucá extract, gas chromatography coupled to mass spectrometry measurements revealed the main compounds as ellagic acid, valoneic acid dilactone, gallotannin, and gallic acid. The Jucá hydroalcoholic extract did not show cytotoxic activity per MTT, with an IC50 value greater than 100 µg/mL. Regarding the antiplasmodial activity, the Jucá extract presented an IC50 of 11.10 µg/mL with a selective index of nine. Because of its antiplasmodial activity at the tested concentrations and low toxicity, the Jucá extract is presented as a candidate for herbal medicine in the treatment of malaria. To the best of our knowledge, this is the first report of antiplasmodial activity in Jucá.

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“…Despite the fact that Jucá pods (fruits) are widely used for wound healing in the Amazon region, limited scientific literature is available. There are reports of wound healing properties of different parts of the plant (such as seeds and bark), in goats, (7) donkeys (14), and Wistar rats (15). Kobayashi et al (16), using two ethanolic extracts (12.5 and 50%) of Jucá pods for wound healing in rats, surprisingly found that the negative control was more efficient for wound retraction.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Phytopharmaceuticals From the Amazonian Plant Libidibia ferrea for Wound Healing in Dogs

et al. 2020

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We comparatively evaluate two distinct formulations containing 5% of Jucá (Libidibia ferrea) for wound healing in dogs. An excision model study was performed in 11 dogs with three dermal wounds in each animal, which were treated with: (1) topical phytopharmaceutical based on Carbopol (PyC) containing 5% Jucá ethanolic extract; (2) topical phytopharmaceutical based on Astrocaryum murumuru butter (PyM) containing 5% Jucá ethanolic extract; and (3) commercial ointment (control). Wound treatment was carried out on alternated days starting at day (D) one until D21. Macroscopic (all time-points) and histological (D0 and D21) analyses were performed. The antimicrobial activity of Jucá was evaluated through Minimal Inhibitory Concentration (MIC). Phytochemical analysis of Jucá revealed 3.1% phenolic compound content expressed in rutin and the presence of hydrolyzable tannins and flavonoids. The mean wound retraction was 33.7 ± 5.5, 34.0 ± 4.7, and 28.4 ± 4.9 % for PyC, PyM, and control groups, respectively, with higher wound retraction for both herbal-treated groups compared to the control (P < 0.05). Alcoholic extract of Jucá had antimicrobial activity against the microorganisms Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida krusei at different degrees, with MIC ranging from 250 to 16.625 µg/ml. Microscopic evaluation showed that the phytotherapic formulations contributed to better dermal wound healing through wound fibroplasia. The alcoholic extract of Jucá pods has great potential for wound healing in dogs and can be used in the development of commercially viable phytotherapic formulations.

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Evaluation macroscopically scar of the string bean and the hull of the caesalpinia ferrea (tul.) Martius (“jucá”) on the cutaneous wounds of the asinines (equus asinus)

Cited by 3 publications

References 0 publications

Biosynthesis of silver nanoparticles using Caesalpinia ferrea (Tul.) Martius extract: physicochemical characterization, antifungal activity and cytotoxicity

Biosynthesis of silver nanoparticles using Caesalpinia ferrea (Tul.) Martius extract: physicochemical characterization, antifungal activity and cytotoxicity

Antiplasmodial Activity of Hydroalcoholic Extract from Jucá (Libidibia ferrea) Pods

Efficacy of Phytopharmaceuticals From the Amazonian Plant Libidibia ferrea for Wound Healing in Dogs

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