Evaluation in 3 Months Duration of Neointimal Coverage After Zotarolimus-Eluting Stent Implantation by Optical Coherence Tomography

Abstract

Most of the stent struts were covered with neointima, and late acquired malapposition was not found at 3 months after ZES implantation. Therefore, the current study demonstrated that ZES might have a favorable in vivo vascular response at 3 months after stent implantation. (Evaluation of Zotarolimus Eluting Stent at 3 Months Using Optical Coherence Tomography [ENDEAVOR OCT]; NCT00815139).

Single-centre all-comers registry reveals promising long-term clinical results of the Endeavor<sup>TM</sup>-Stent

“…This has also been demonstrated in direct comparison against the Taxus TM -and the Cypher TM -Stent [12,13]. Recently, it has been proven, that the Endeavor TM -Stent showed better endothelial strut coverage even in myocardial infarction in comparison to other DES [32][33][34]. However, the SORT OUT III trial revealed a low (1%) but significantly higher rate of definite stent-thrombosis after nine months in comparison to sirolimus-eluting stents [23].…”

Three-Month Dual Antiplatelet Therapy After Implantation of Zotarolimus-Eluting Stents - The DATE (Duration of Dual Antiplatelet Therapy After Implantation of Endeavor Stent) Registry -

“…14 Several clinical studies have also supported the safety of ZES. In optical coherence tomography studies, most of the stent struts were covered with neointima at 3 months after ZES implantation, 15 and exposure of stent struts and thrombi was observed less frequently in patients undergoing PCI with ZES than in those undergoing PCI with SES at 9 months follow up. 16 In other OCT studies, uncovered struts were frequently observed in SES at 9-12 months.…”

“…12 Several animal and human studies support the safety of ZES. [13][14][15][16][17] Theoretically, the duration of dual antiplatelet therapy can be shorter with ZES than with other stents. This study aims to determine the feasibility of 3-month dual antiplatelet therapy after ZES implantation in relatively lowrisk patients with coronary artery disease.…”

Coronary Angioscopy for the Evaluation of Vessel Response After Drug-Eluting Stent Implantation

“…3 Clinical investigation has shown that the E-ZES had nearly complete neointimal coverage at 3 months. 4 Sufficient arterial repair characterized by less development of thrombus, and substantial neointima formation occurred by 4 months after E-ZES implantation. 5 Such more rapid arterial repair than with other DES may contribute to neointimal stability.…”