Évaluation du statut osseux des patients en attente d’une greffe hépatique

Wibaux, Cécile; Legroux-Gérot, Isabelle; Dharancy, Sébastien; Boleslawski, Emmanuel; Declerck, Nicole; Canva, V.; Pruvot, François‐René; Cortet, Bernard

doi:10.1016/j.rhum.2010.11.012

Cited by 1 publication

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“…Its prevalence varies considerably and ranges from 20% to 50% [ 5 ]. It is related to the severity of cirrhosis and affects 38% of patients awaiting liver transplantation [ 6 , 7 ]. Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue leading to bone fragility and increased fracture risk, a source of morbidity and mortality in patients already weakened by their chronic liver disease.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Bone Disease in Viral Cirrhosis: A Prospective Study

et al. 2013

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Background/Aim. Metabolic Bone disorders are well-recognized extrahepatic complications of cirrhosis. The aim was to report their prevalence and the associated factors to their development in patients with viral cirrhosis. Patients and Methods. All consecutive patients with viral cirrhosis were prospectively enrolled. Parathyroid hormone, 25-hydroxyvitamin D, liver function, and phosphocalcic tests were measured in all patients. Bone mineral density was measured at the lumbar spine and total hip by dual-energy X-ray absorptiometry. Data were analyzed using SPSS software. Results. Forty-six cirrhotic patients were included with hepatitis C (87%) and hepatitis B (13%). The Child-Pugh score was grade A in 87% of cases and grade B in 13%. Thirty-seven patients had decreased bone mineral density with osteopenia in 24 patients and osteoporosis in 13 patients. Decreased 25-hydroxyvitamin D was found in 95.6% of cases. Bone disorders were significantly more frequent in old patients with low body mass index, long duration of liver disease, and low 25-hydroxyvitamin D level. None of these factors was an independent factor associated with bone disorders. Conclusion. Our study revealed a high prevalence of metabolic bone disorders among viral cirrhotic patients. Consequently, bone mineral density assessment should be performed systematically in all cirrhotic patients.

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Section: Introductionmentioning

confidence: 99%