Évaluation du risque transfusionnel vis-à-vis de la variante de la maladie de Creutzfeldt-Jakob en France

From mad cows to sensible blood transfusion: the risk of prion transmission by labile blood components in the United Kingdom and in France

“…). The prevalence of infection in blood donors: a great uncertainty exists about this prevalence that will depend upon that in the general population who were exposed through diet in the UK and in France. A calculation taking into account the higher end of the estimate of between 6 and 300 persons infected in the general French population and imagining these 300 cases among the 36 million subjects who are in the age range to be blood donors (18‐65 years) and eligible to be donors, and assuming that they could be infective during the whole incubation period, results in a prevalence of 1 in 120,000: that is approximately 8 infected individuals per 1 million donors, which is close to 11 infected donations per year—in a worst case scenario 67 . In a recent reevaluation, the number of expected vCJD cases in France was revised downward (maximum of 100 cases instead of 300), leading to an estimate of 1 donor infected in 1/360,000.…”