Évaluation des états mentaux à risque de transition psychotique : validation de la version française de la CAARMS

Krebs, Marie‐Odile; Magaud, Emilie; Willard, Dominique; Elkhazen, C; Chauchot, F.; Gut, A.; Morvan, Yannick; Bourdel, Marie‐Chantal; Kazes, Mathilde

doi:10.1016/j.encep.2013.12.003

Cited by 46 publications

(17 citation statements)

References 37 publications

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“…To date, CAARMS has been translated into several languages and is the psychometric instrument used most frequently to diagnose ultra‐high‐risk (UHR) (Krebs et al, ). Individuals with sub‐threshold clinical features, such as attenuated psychotic symptoms (APS) or brief limited intermittent psychotic symptoms (BLIPS), associated with a significant decline in global functioning in the presence of genetic risk factors ( Trait ), are clinically grouped under the term “ultra‐high risk (UHR).” Other terms, such as “clinical high risk (CHR)” or “at‐risk mental states (ARMS)”, are also used (Shaikh et al, ).…”

Section: Introductionmentioning

confidence: 99%

Early intervention for everyone? A review of cross‐cultural issues and their treatment in ultra‐high‐risk (UHR) cohorts

Deriu

Moro

Benoit

2018

Early Intervention Psych

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This systematic review demonstrates barriers to the access to participation in early intervention research for migrants and ethnic minorities. This selection bias may result in lower validity for the CAARMS among these populations and thus in inadequate intervention programmes. Along with targeted studies, minorities' access to participation in UHR cohorts should be improved through 3 tools: interpreters at recruitment and for administration of CAARMS, a guide to cultural formulation and transcultural data collection.

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Section: Introductionmentioning

confidence: 99%

Early intervention for everyone? A review of cross‐cultural issues and their treatment in ultra‐high‐risk (UHR) cohorts

Deriu

Moro

Benoit

2018

Early Intervention Psych

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“…Participants were recruited through the French ICAAR cohort (PHRC AOM-07-118, promoted by Hôpital Sainte-Anne) among help-seeking individuals (16 to 30 years old) consecutively referred to the Adolescent and Young Adult Assessment Centre (Service Hospitalo-Universitaire, Hôpital Sainte-Anne, Paris, France) between 2009 and 2014 ( 23 ). All help-seeking individuals were examined at baseline and after 1 year follow-up with the Comprehensive Assessment of at-risk mental state, CAARMS ( 24 ), in its translated version ( 25 ), by specifically trained psychiatrists. After baseline assessment, a consensus meeting for best estimated diagnosis was held, and help-seekers were classified as at-risk for psychosis stage IA or stage IB according to the staging model distinction ( 26 ).…”

Section: Methodsmentioning

confidence: 99%

Stress, Cortisol and NR3C1 in At-Risk Individuals for Psychosis: A Mendelian Randomization Study

Iftimovici

Kébir

et al. 2020

Front. Psychiatry

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IntroductionThe emergence of psychosis in at-risk individuals results from interactions between genetic vulnerability and environmental factors, possibly involving dysregulation of the hypothalamic-pituitary-adrenal axis. Hypercorticism was indeed described in schizophrenia and ultra-high-risk states, but its association with clinical outcome has yet to be demonstrated. The impact of stress through cortisol may vary depending on the expression level of genes related to the stress pathway.MethodsTo test this hypothesis, we selected NR3C1, the gene encoding the glucocorticoid receptor, and modeled through logistic regression how its peripheral expression could explain some of the risk of psychosis, independently of peripheral cortisol levels, in a French longitudinal prospective cohort of 133 at-risk individuals, adjusted for sex, age, cannabis, and antipsychotic medication intake. We then performed a genome-wide association analysis, stratified by sex (55 females and 78 males), to identify NR3C1 expression quantitative trait loci to be used as instrumental variables in a Mendelian randomization framework.ResultsNR3C1 expression was significantly associated with a higher risk of conversion to psychosis (OR = 2.03, p = 0.03), independently of any other factor. Cortisol was not associated with outcome nor correlated with NR3C1. In the female subgroup, rs6849528 was associated both with NR3C1 mRNA levels (p = 0.015, Effect-Size = 2.7) and conversion (OR = 8.24, p = 0.03).ConclusionsFor the same level of cortisol, NR3C1 expression increases psychotic risk, independently of sex, age, cannabis, and antipsychotic intake. In females, Mendelian randomization confirmed NR3C1’s effect on outcome to be unbiased by any environmental confounder.

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“…Inclusion criteria were global functioning alterations (Social and Occupational Functioning Assessment Scale score <70) during the past year, associated with psychiatric symptoms and/or subjective cognitive complaints. All participants were examined by specifically trained psychiatrists, using a translated French version 13 of the Comprehensive Assessment for at-risk mental states (CAARMS 14 ). Best-estimate diagnoses were allocated at a subsequent consensus meeting.…”

Section: Methodsmentioning

confidence: 99%

Epigenetic variability in conversion to psychosis: novel findings from an innovative longitudinal methylomic analysis

2018

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Conversion to psychosis is a longitudinal process during which several epigenetic changes have been described. We tested the hypothesis that epigenetic variability in the methylomes of ultra-high risk (UHR) individuals may contribute to the risk of conversion. We studied a longitudinal cohort of UHR individuals (n = 39) and compared two groups (converters, n = 14 vs. non-converters, n = 25). A longitudinal methylomic study was conducted using Infinium HumanMethylation450 BeadChip covering half a million cytosine–phosphate–guanine (CpG) sites across the human genome from whole-blood samples. We used two statistical methods to investigate the variability of methylation probes. (i) The search for longitudinal variable methylation probes (VMPs) based on median comparisons identified two VMPs in converters only. The first CpG was located in the MACROD2 gene and the second CpG was in an intergenic region at 8q24.21. (ii) The detection of outliers using variance analysis related to private epimutations identified a dozen CpGs in converters only and highlighted two genes (RAC1 and SPHK1) from the sphingolipid signaling pathway. Our study is the first to support increased methylome variability during conversion to psychosis. We speculate that stochastic factors could increase DNA methylation variability and have a role in the complex pathophysiology of conversion to psychosis as well as in other psychiatric diseases.

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Évaluation des états mentaux à risque de transition psychotique : validation de la version française de la CAARMS

Cited by 46 publications

References 37 publications

Early intervention for everyone? A review of cross‐cultural issues and their treatment in ultra‐high‐risk (UHR) cohorts

Early intervention for everyone? A review of cross‐cultural issues and their treatment in ultra‐high‐risk (UHR) cohorts

Stress, Cortisol and NR3C1 in At-Risk Individuals for Psychosis: A Mendelian Randomization Study

Epigenetic variability in conversion to psychosis: novel findings from an innovative longitudinal methylomic analysis

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