Évaluation de la performance de cinq tests de diagnostic rapide pour le dépistage du virus de l’Immunodéficience Humaine (VIH 1 &amp; 2) au Tchad

Mbanga, Djimadoum; Nadlaou, Bessimbaye; Moussa, Ali Mahamat; Tidjani, Abdelsalam; Narassem, Mbaidoum; Narbe, Maxime Djimadengar; Sangba, Alexis; Barro, Nicolas

doi:10.4314/ijbcs.v12i5.18

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…In earlier studies in the Ivory Coast (19), Mongolia (20) and the Democratic Republic of Congo (DRC) (21), this kit showed a better performance with a sensitivity ranging from 98.84-100%. Unlike our study, in these populations; it met the WHO prequali cation criteria of a sensitivity of ≥ 99% (22). Lower sensitivities can lead to misidenti cation of HBV infection cases (10).…”

Section: Discussionmentioning

confidence: 68%

“…Similarly, the other four study kits had speci city values ranging from 95-97%, comparable to the 97.0% listed by their manufacturers. Thus, all the study RDTs met the WHO recommendation of a speci city of ≥ 95% (22). For the purposes of screening and diagnosis, the sensitivity and speci city pro les of the rather inexpensive RDTs: Astracare, Accurate, One Step, and NOVA would qualify them as reasonably accurate and affordable testing platforms in resource-limited settings whose populations are highly under-tested for HBV.…”

Section: Discussionmentioning

confidence: 94%

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Diagnostic Performance of Four Hepatitis B Surface Antigen Conformité Européenne (CE) Marked and One WHO Prequalified Rapid Diagnostic Tests in Uganda

Baliruno,

Kato,

Nakigozi

et al. 2024

Preprint

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Background Globally, over 296 million people are infected with chronic Hepatitis B (HBV). Eighty million of these reside in sub-Saharan Africa (SSA). HBV claims an estimated one million lives annually. Efforts to eradicate it from SSA have been slow partly due to a lack of affordable accurate screening tools. The diagnostic accuracy of the commonly used rapid diagnostic tests (RDTs) in SSA is poorly understood hence a need to characterize the validity of five RDTs being used for HBV diagnosis using the Hepatitis B surface antigen (HBsAg) serologic marker. Methods In this cross-sectional study, 200 samples of residual donor blood were screened for HBsAg using the Chemiluminescent Microparticle Immunoassay (CMIA) and results confirmed by Enzyme-Linked Immunosorbent Assay (ELISA). They were subsequently subjected to five RDT kits; the SD Bioline, a World Health Organization (WHO) pre-qualified test kit, and four Conformité Européenne (CE) Marked RDTs: One-Step, NOVA, Astracare and Accurate. The sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV) were computed using ELISA as the reference test. The Statistical Program for Social Sciences (SPSS 20.0 for Windows; SPSS Inc. Chicago, IL) was used for statistical analysis. Results All five RDT brands demonstrated a sensitivity of 93% (95% CI 93%- 93%). Their specificity however ranged from 95% (95% CI 94.9%- 97.8%) for Astracare to 98% (95% CI 94.9%- 98.0%) for SD Bioline. Similarly, their positive PPV ranged from 94.89% (95% CI 94.9%-97.7%) for Astracare to 97.89% (95% CI 94.9%-98.0%) for SD Bioline and NPV ranged from 93.14% (95% CI 93.1%-93.3%) for Astracare and 93.33% (95% CI 93.1% -93.3%) for SD Bioline. Conclusion SD Bioline had the best diagnostic accuracy for HBV infection. Nevertheless, the less expensive CE-marked RDTs had good performance characteristics. CE marked RDTs thus present an opportunity for massive screening of the at-risk populations in the WHO-led campaign to eliminate HBV as a public health threat in Uganda and other low-resource settings by 2030.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 94%

Diagnostic Performance of Four Hepatitis B Surface Antigen Conformité Européenne (CE) Marked and One WHO Prequalified Rapid Diagnostic Tests in Uganda

Baliruno,

Kato,

Nakigozi

et al. 2024

Preprint

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“…The analytical precision of the Sickle Scan RDT was assessed in comparison to the Gold Standard of Hb electrophoresis + Emmel test. The intrinsic features of the Sickle Scan RDT such as its sensitivity, its specificity, its positive likelihood ratio and its negative likelihood ratio were determined (Nendaz et Perrier, 2004;Delacour et al, 2009;Steichen et al, 2013;Djimadoum et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the diagnostic accuracy of a hemoglobin S and C screening test: Sickle Scan

Adjé¹,

Yapo²,

Yayo-Ayé³

et al. 2021

Int. J. Bio. Chem. Sci

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New tools for the rapid diagnosis of hemoglobinosis could encourage the extension of their screening in Africa. Our goal was to assess the analytical performances of a rapid hemoglobin S and C detection test, the Sickle Scan. This was a cross-sectional study carried out in March 2019 at the Yopougon Teaching Hospital. The subjects followed for hemoglobinosis as well as the subjects seeking out an electrophoresis of their hemoglobin were included. We carried out the hemogram, the electrophoresis of hemoglobin at alkaline pH (reference method) coupled with the metabisulfite sickling test (Emmel test) and the rapid detection test to be evaluated. This immunochromatographic test is capable of detecting hemoglobins A, S, and C, and to infer the hemoglobin phenotype from there. The study recruited 191 individuals. The test detected hemoglobins S and C with a sensitivity of 99.4% and 97.7% respectively; a specificity of 93.3% and 99.3%. The positive likelihood ratio for hemoglobins S and C was 15 and 144 respectively. The negative likelihood ratio was 0.01 for hemoglobin S, and 0.02 for hemoglobin C. The intrinsic characteristics obtained make this test an interesting screening tool for hemoglobinosis S and C. Keywords: Diagnostic test, hemoglobinosis, Abidjan, sensitivity, specificity.

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Evaluation of the analytical performance of six rapid diagnostic tests for the detection of viral hepatitis B and C in Lubumbashi, Democratic Republic of Congo

Kabamba

Mwamba

Dessilly

et al. 2020

Journal of Virological Methods

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Évaluation de la performance de cinq tests de diagnostic rapide pour le dépistage du virus de l’Immunodéficience Humaine (VIH 1 & 2) au Tchad

Cited by 3 publications

References 2 publications

Diagnostic Performance of Four Hepatitis B Surface Antigen Conformité Européenne (CE) Marked and One WHO Prequalified Rapid Diagnostic Tests in Uganda

Diagnostic Performance of Four Hepatitis B Surface Antigen Conformité Européenne (CE) Marked and One WHO Prequalified Rapid Diagnostic Tests in Uganda

Evaluation of the diagnostic accuracy of a hemoglobin S and C screening test: Sickle Scan

Evaluation of the analytical performance of six rapid diagnostic tests for the detection of viral hepatitis B and C in Lubumbashi, Democratic Republic of Congo

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