Évaluation de la déformabilité érythrocytaire des sujets porteurs de trait drépanocytaire au cours d’un match de football : effet de l’hydratation ad libitum

Abstract

This study compared erythrocyte changes between a group of subjects with sickle cell trait (SCT) and controls (subjects without hemoglobinopathy) during a soccer game in two conditions: with and without hydration. Erythrocyte deformability of subjects was assessed by the coefficient of erythrocyte rigidity (Tk) which was calculated before and after football match. Our results showed a significant increase in erythrocyte rigidity (Tk) in SCT at the end of physical activities without hydration; however when water was provided ad libitum their Tk decreased significantly, reaching values of controls. And adequate hydration is recommended in subjects with sickle cell trait during and after exercise.

Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory

“…In the general population, exercise causes a rise of blood viscosity as a consequence of the increase of haematocrit and plasma viscosity and the changes in RBC rheological properties (i.e., deformability and aggregation). Exercise also leads to a rise of blood viscosity in SCT with an increase that is more pronounced than in healthy individuals, particularly in subjects who are dehydrated (Diaw, et al 2013b, Tripette, et al 2010c). Theoretically, this amplified response could increase the risks for end organ perfusion disorders in SCT, but only when vascular reactivity is blunted.…”