Evaluation and Simulation of Colon Cancer Treatment Techniques with Fuzzy PROMETHEE

Ozsahin, Dilber Uzun; Nyakuwanikwa, Kudakwashe; Wallace, Tapiwa; Ozsahin, Ilker

doi:10.1109/icaset.2019.8714509

Cited by 11 publications

(2 citation statements)

References 11 publications

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“…Two pieces of data are necessary for the PROMETHEE technique to work effectively: preference functions and the importance weight of the criteria [34,35]. In the PROMETHEE approach, six distinct preference functions are available for the determination of the preference of alternatives compared to others for each criteria: normal, U-shaped, V-shaped, level, linear, and Gaussian preference functions [36,37].…”

Section: Application Of Fuzzy Prometheementioning

confidence: 99%

A Multi-Criteria Decision Aid Tool for Radiopharmaceutical Selection in Tau PET Imaging

Ozsahin

Onakpojeruo²,

Uzun

et al. 2023

Pharmaceutics

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The accumulation of pathologically misfolded tau is a feature shared by a group of neurodegenerative disorders collectively referred to as tauopathies. Alzheimer’s disease (AD) is the most prevalent of these tauopathies. Immunohistochemical evaluation allows neuropathologists to visualize paired-helical filaments (PHFs)—tau pathological lesions, but this is possible only after death and only shows tau in the portion of brain sampled. Positron emission tomography (PET) imaging allows both the quantitative and qualitative analysis of pathology over the whole brain of a living subject. The ability to detect and quantify tau pathology in vivo using PET can aid in the early diagnosis of AD, provide a way to monitor disease progression, and determine the effectiveness of therapeutic interventions aimed at reducing tau pathology. Several tau-specific PET radiotracers are now available for research purposes, and one is approved for clinical use. This study aims to analyze, compare, and rank currently available tau PET radiotracers using the fuzzy preference ranking organization method for enrichment of evaluations (PROMETHEE), which is a multi-criteria decision-making (MCDM) tool. The evaluation is based on relatively weighted criteria, such as specificity, target binding affinity, brain uptake, brain penetration, and rates of adverse reactions. Based on the selected criteria and assigned weights, this study shows that a second-generation tau tracer, [18F]RO-948, may be the most favorable. This flexible method can be extended and updated to include new tracers, additional criteria, and modified weights to help researchers and clinicians select the optimal tau PET tracer for specific purposes. Additional work is needed to confirm these results, including a systematic approach to defining and weighting criteria and clinical validation of tracers in different diseases and patient populations.

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Section: Application Of Fuzzy Prometheementioning

confidence: 99%

A Multi-Criteria Decision Aid Tool for Radiopharmaceutical Selection in Tau PET Imaging

Ozsahin

Onakpojeruo²,

Uzun

et al. 2023

Pharmaceutics

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“…The PROMETHEE technique was developed by Brans and Vincle in 1985 [32]. Since then, it has been used successfully as an MCDM technique in many fields [33], and recently, it has been applied to medicine, healthcare [34][35][36][37][38][39][40][41][42][43] etc. VIKOR is another commonly-used MCDM technique that determines the order of alternatives under conflicting criteria based on the closeness to the ideal solution [44].…”

Section: Introductionmentioning

confidence: 99%

A Clinical Decision Support System for the Treatment of COVID-19 with Multi-Criteria Decision-Making Techniques (Preprint)

Ozsahin¹

2020

Preprint

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BACKGROUND The outbreak of coronavirus disease 2019 (COVID-19) was first reported in December 2019. Until now, many drugs and methods have been used in the treatment of the disease. However, no effective treatment option has been found and only case-based successes have been achieved so far. OBJECTIVE This study aims to evaluate the COVID-19 treatment options using multi-criteria decision-making (MCDM) techniques. METHODS In this study, we evaluated the available COVID-19 treatment options by MCDM techniques, namely fuzzy PROMETHEE and VIKOR. This technique is based on the evaluation and comparison of complex and multiple criteria to evaluate the most appropriate alternative. We evaluated current treatment options including favipiravir (FPV), lopinavir/ritonavir, hydroxychloroquine, interleukin-1 blocker, intravenous immunoglobulin (IVIG), and plasma exchange. The criteria used for the analysis include side effects, method of administration of the drug, cost, turnover of plasma, level of fever, age, pregnancy, and kidney function. RESULTS The results showed that plasma exchange was the most preferred alternative, followed by FPV and IVIG, while hydroxychloroquine was the least favorable one. New alternatives could be considered once they are available, and weights could be assigned based on the opinions of the decision makers (physicians/clinicians). CONCLUSIONS We showed the applicability of the MCDM techniques in informing decision makers in choosing the right treatment technique for the management of COVID-19.

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Introduction

Ozsahin

Uzun

Syidanova

et al. 2021

Application of Multi-Criteria Decision Analysis in Environmental and Civil Engineering

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Evaluation and Simulation of Colon Cancer Treatment Techniques with Fuzzy PROMETHEE

Cited by 11 publications

References 11 publications

A Multi-Criteria Decision Aid Tool for Radiopharmaceutical Selection in Tau PET Imaging

A Multi-Criteria Decision Aid Tool for Radiopharmaceutical Selection in Tau PET Imaging

A Clinical Decision Support System for the Treatment of COVID-19 with Multi-Criteria Decision-Making Techniques (Preprint)

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