Evaluation and optimization of pH-responsive niosomes as a carrier for efficient treatment of breast cancer

Salem, Heba F.; Kharshoum, Rasha M; El-Ela, Fatma I. Abo; Gamal, Amr; Abdellatif, Khaled R.A.

doi:10.1007/s13346-018-0499-3

Cited by 49 publications

(28 citation statements)

References 25 publications

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“…Additionally, it provides 3D graphs for assessing the impact of independent variables on Y 1 -Y 4 . After analysis of all quantative outcomes of Y 1 -Y 4 , the point prediction method was used to select the optimum formulation [21].…”

Section: Optimization Of Rldl Formulationsmentioning

confidence: 99%

The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer

et al. 2021

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Breast cancer is the most frequent malignancy in women. This work focuses on developing deformable liposomes as a potential carrier for breast cancer treatment and studying the impact of improving dermal permeation on the efficacy and targeting of liposomes. Raloxifene (RXF), an oestrogen antagonist, was used as a model drug. Using Box–Behnken design, different formulations of RXF-loaded deformable liposome (RLDL) were prepared using different propylene glycol, phospholipid and cholesterol concentrations. The percentage of entrapment efficiency (Y1), particle size (Y2), zeta potential (Y3) and steady-state flux (Y4) of the prepared formulations were all evaluated. Y1 and Y4 were significantly increased and Y2 and Y3 were significantly decreased when the propylene glycol concentration was increased. The optimization was obtained and the optimum formulation was that including phospholipid (1.40% w/w), cholesterol (0.15% w/w) and propylene glycol (10% v/v). The selected optimum formulation displayed a % EE of 78.34 ± 1.04% with a steady-state flux of 4.21 ± 0.02 µg/cm2/h. In order to investigate bioavailability, antitumor effectiveness and permeation, the optimum formulation was selected and included in a carbopol gel. The optimum gel formulation had 2.77 times higher bioavailability and, as a result, considerable antitumor action as compared to oral RXF. In conclusion, optimum RLDL gel may be an effective breast cancer treatment.

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Section: Optimization Of Rldl Formulationsmentioning

confidence: 99%

The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer

et al. 2021

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“…All experiments were carried out in triplicate and sample size was calculated by taking average of the three runs. 15 , 16 The samples were analyzed using one-way ANOVA statistical test. The data were normally distributed, and the distribution was tested with Kolmogorov–Smirnov test.…”

Section: Methodsmentioning

confidence: 99%

Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation

Abou-Taleb¹,

Khallaf²,

Abdel-Aleem³

2018

DDDT

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ObjectiveOne of the greatest challenges drug formulation is facing is poor bioavailability via oral route. In this regard, nasal drug delivery has been commonly used as an alternative route to improve drug bioavailability. Nefopam hydrochloride (NF) is an analgesic drug that suffers from poor bioavailability due to extensive metabolism in liver. Accordingly, the goal of the present study was to improve NF bioavailability via niosomal-based formulation designed for intranasal delivery.Materials and methodsVesicles were developed by mixing surfactants (Span 20, Span 40, Span 80, and Span 85) at four molar ratios of 1:1, 1:2, 1:3, and 1:4 of cholesterol to surfactant. Entrapment efficiency, particle size, zeta potential, release percentage, ex-vivo permeation parameters, and niosomes’ stability were determined. Also, the pharmacokinetic parameters of the optimized formula in in-situ gel base were measured in rats.ResultsNiosomes showed entrapment efficiency .80%, particle size ,550 nm, and zeta potential ranging from -16.8±0.13 to -29.7±0.15. The produced vesicles showed significantly higher amounts of drug permeated across nasal mucosa (2.5 folds) and prolonged NF release compared with NF solution. Stability studies of optimum formula showed nonsignificant changes in niosomes parameters over a storage period of 6 months. The in-vivo studies showed a 4.77-fold increase in bioavailability of optimized nasal niosomes compared with oral solution of drug.ConclusionThe obtained results revealed the great ability of the produced NF-loaded nio-somes to enhance drug penetration through nasal mucosa and improve its relative bioavailability compared with NF oral solution.

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“…Niosomes can be also used as carriers for the delivery of chemical drugs for the treatment of cancer due to their smaller size, offering a possibility of enhanced permeability and retention in tumor tissue [68]. Niosomes are also incorporated into hydrogels and chitosan/glyceryl monooleate (CH/GMO) as a pH sensitive formulation for the efficient treatment of cancer [69].…”

Section: The Application Of the Niosomes In Chemical Drugs Proteimentioning

confidence: 99%

Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

et al. 2019

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Non-Ionic surfactant based vesicles, also known as niosomes, have attracted much attention in pharmaceutical fields due to their excellent behavior in encapsulating both hydrophilic and hydrophobic agents. In recent years, it has been discovered that these vesicles can improve the bioavailability of drugs, and may function as a new strategy for delivering several typical of therapeutic agents, such as chemical drugs, protein drugs and gene materials with low toxicity and desired targeting efficiency. Compared with liposomes, niosomes are much more stable during the formulation process and storage. The required pharmacokinetic properties can be achieved by optimizing components or by surface modification. This novel delivery system is also easy to prepare and scale up with low production costs. In this paper, we summarize the structure, components, formulation methods, quality control of niosome and its applications in chemical drugs, protein drugs and gene delivery.

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Evaluation and optimization of pH-responsive niosomes as a carrier for efficient treatment of breast cancer

Cited by 49 publications

References 25 publications

The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer

The Impact of Improving Dermal Permeation on the Efficacy and Targeting of Liposome Nanoparticles as a Potential Treatment for Breast Cancer

Intranasal niosomes of nefopam with improved bioavailability: preparation, optimization, and in-vivo evaluation

Advances of Non-Ionic Surfactant Vesicles (Niosomes) and Their Application in Drug Delivery

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