Evaluation and Multivariate Statistical Analysis of Factors Influencing Patient Adherence to Ophthalmic Solutions

Abstract

In this study, factors in‰uencing patients adherence to ophthalmic solutions were investigated. Seventy-one subjects (aged 62.3±15.5 years) were randomly selected from patients admitted to the Ophthalmology Department at Hiroshima University Hospital. The patients (n＝71) completed questionnaires, which were evaluated by clinical pharmacists. The patient group to which the ophthalmic solutions were applied once or twice daily was more compliant than other patient groups ( p＝0.00057). A multivariate statistical analysis revealed that the factors in‰uencing patients adherence were the number of ophthalmic solutions used, patient age, taste, administration intervals, the number of drops used, and hand washing before the application of ophthalmic solutions. Patients who understood the signiˆcance of the medication made fewer mistakes than those who understood only the route of administration but not the signiˆcance. In conclusion, our study shows that patient counseling should emphasis the signiˆcance of the administered medicine as well as the route of administration.

Ocular Pharmacokinetics of a Single Dose of Bromfenac Sodium Ophthalmic Solution 0.1% in Human Aqueous Humor

“…However, research has demonstrated the benefits of reduced dosing schedules increasing patient compliance and convenience. 44 In addition, less frequent dosing reduces the exposure of ocular tissues to both the active drug and any preservatives in the solution. Further, the concentration of bromfenac required to produce clinical efficacy is much lower as a result of its greater potency.…”

Evaluation of Aqueous Humor Concentrations of Istalol® and Betimol® Following a Single Ocular Instillation in Rabbit Eyes

“…Also, the greater residence time in the target ocular tissues permits less frequent dosing, which increases adherence among patients with chronic conditions. [3][4][5] TLA combines timolol maleate at a 0.5% concentration with potassium sorbate and reduces the benzalkonium chloride preservative to 0.005%. TLA has been shown in a large, multicenter, randomized, double-masked clinical trial, to be safe and effective in patients with open-angle glaucoma or ocular hypertension.…”

“…This convenience leads to better patient adherence with the recommended regimen for these chronic conditions. [3][4][5] There are two factors to consider in increasing ocular bioavailability: increasing precorneal retention (i.e., reducing tear-flow drainage) and increasing transcorneal absorption across the corneal diffusion barrier into the aqueous humor. There have been various studies addressing these alternatives, such as use of a prodrug, 6 use of ophthalmic inserts, 7 and a gel-forming solution, 8,9 which prolongs precorneal retention, but also causes blurred vision because of the increased viscosity of the preparation.…”

“…Also, the greater residence time in the target ocular tissues permits less frequent dosing, which increases adherence among patients with chronic conditions. [3][4][5] This new formulation of timolol maleate was evaluated in a small group of healthy subjects 13 and, subsequently, in a larger clinical trial with patients diagnosed with either openangle glaucoma or ocular hypertension. 14 Mundorf and associates 14 evaluated, in a double-masked, randomized cross-over study, the systemic bioavailability of timolol maleate with sorbic acid, timolol-LA (TLA, Istalol ® ), compared to that of generic timolol maleate ophthalmic solution (TIM).…”

Global Experience With Xibrom (Bromfenac Ophthalmic Solution) 0.09%: The First Twice-daily Ophthalmic Nonsteroidal Anti-inflammatory Drug

“…Although the impact of dosing is probably more pronounced over chronic therapy, even acute therapy can be undermined by poor compliance related to frequency of dosing. Ikeda and colleagues 49 have shown that subjects who were prescribed ophthalmic drops once or twice a day are much more compliant than subjects with more frequent dosing regimens. Comfort, which is a key component of overall patient satisfaction, has become more important with the increase in elective ophthalmic procedures.…”