Evaluation and management of longitudinally extensive transverse myelitis: a guide for radiologists

Mirbagheri, Saeedeh; Sorte, Danielle Eckart; Zamora, Carlos; Mossa‐Basha, Mahmud; Newsome, Scott D.; Izbudak, Izlem

doi:10.1016/j.crad.2016.05.020

Cited by 21 publications

(8 citation statements)

References 75 publications

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“…Longitudinally extensive transverse myelitis (LETM) is a magnetic resonance imaging diagnosis defined as intramedullary hyperintense T2-weighted signal abnormality spanning three or more vertebral segments (Wingerchuk et al 2006). The differential diagnosis of LETM is broad, including compressive, infective, demyelinating/inflammatory, vascular and neoplastic causes (Mirbagheri et al 2016), although use of this terminology commonly implies a demyelinating/inflammatory aetiology. We now report a paediatric patient from the LHON Qld1 family with extensive myelopathy resembling LETM.…”

Section: Introductionmentioning

confidence: 99%

Leber Hereditary Optic Neuropathy and Longitudinally Extensive Transverse Myelitis

et al. 2017

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Leber Hereditary Optic Neuropathy is an inherited optic neuropathy caused by mitochondrial DNA point mutations leading to sudden, painless loss of vision. We report a case of an 8-year-old boy presenting with a radiological phenotype of longitudinally extensive transverse myelitis on a background of severe visual impairment secondary to Leber Hereditary Optic Neuropathy (LHON). He was found to have dual mitochondrial DNA mutations at 14484 (MTND6 gene) and 4160 (MTND1 gene) in a family with a severe form of LHON characterised by not only an unusually high penetrance of optic neuropathy, but also severe extra-ocular neurological complications. The m.14484T>C mutation is a common LHON mutation, but the m.4160T>C mutation is to our knowledge not reported outside this family and appears to drive the neurological manifestations. To our knowledge there have been no previous reports of spinal cord lesions in children with LHON.

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Section: Introductionmentioning

confidence: 99%

Leber Hereditary Optic Neuropathy and Longitudinally Extensive Transverse Myelitis

et al. 2017

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“…The initial clinical response to treatment may cause development of new lesions or expansion of preexisting ones due to lysis and release of tubercular proteins. [ 9 ] In our patient, LETM was detected before MTB treatment. We consider that in our case, the LETM mechanism is that MTB shares antigens with myelin basic protein, thus sensitizing lymphocytes to mycobacterium and facilitating their attachment to myelin.…”

Section: Discussionmentioning

confidence: 69%

Occult disseminated tuberculosis with holocord longitudinally extensive transverse myelitis: A rare phenomenon in a child

et al. 2017

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Longitudinally extensive transverse myelitis (LETM) is defined as an inflammatory lesion of the spinal cord that extends to three or more segments. LETM is a commonly characteristic feature of neuromyelitis optica (NMO) or various autoimmune diseases. Manifestation of Mycobacterium tuberculosis (MTB) infection with LETM are rare and usually in the cervicothoracic spinal cord. Our patient presented with holocord LETM, so NMO was considered initially diagnosis. After in further research, MTB was diagnosed and treated successfully. The current case underscores that tuberculosis must be keep in mind when undertaking differential diagnosis of demyelinating diseases even in the absence of symptoms of infection, and especially in endemic regions.

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“…LETM has a broad list of differential diagnoses, ranging from multiple sclerosis to spinal cord infarction. LETM is known to have a hyperacute, acute, subacute, or chronic onset [11] . LETM with a subacute onset is seen in subacute degeneration of the spinal cord as mentioned above.…”

Section: Discussionmentioning

confidence: 99%

Subacute combined degeneration of the cervical and dorsal spinal cord in a 40-year-old male patient: A case report

Berkel

Vandevenne

Vangheluwe

et al. 2021

Radiology Case Reports

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Subacute combined degeneration of the spinal cord is a neurologic complication of vitamin B12 deficiency. It presents as a potentially reversible demyelination of the posterior and lateral columns of the cervical and dorsal spinal cord. We present the case of a 40-year-old male with progressive sensory and motor deficit from the lower extremities ascending to the mid-thoracic region. A combination of laboratory tests and magnetic resonance imaging confirmed the diagnosis of subacute degeneration of the spinal cord due to vitamin B12 deficiency.

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Evaluation and management of longitudinally extensive transverse myelitis: a guide for radiologists

Cited by 21 publications

References 75 publications

Leber Hereditary Optic Neuropathy and Longitudinally Extensive Transverse Myelitis

Leber Hereditary Optic Neuropathy and Longitudinally Extensive Transverse Myelitis

Occult disseminated tuberculosis with holocord longitudinally extensive transverse myelitis: A rare phenomenon in a child

Subacute combined degeneration of the cervical and dorsal spinal cord in a 40-year-old male patient: A case report

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