Evaluation and discovery of novel benzothiazole derivatives as promising hits against Leishmania infantum
Thibault Joseph William Jacques Dit Lapierre,
Danilo Nascimento Farago,
Mariza Gabriela Faleiro de Moura Lodi Cruz
et al.
Abstract:An early exploration of the benzothiazole class against two kinetoplastid parasites, Leishmania infantum and Trypanosoma cruzi, has been performed after the identification of a benzothiazole derivative as a suitable antileishmanial initial hit. The first series of derivatives focused on the acyl fragment of its class, evaluating diverse linear and cyclic, alkyl and aromatic substituents, and identified two other potent compounds, the phenyl and cyclohexyl derivatives. Subsequently, new compounds were designed … Show more
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