Evaluation and Correlation of Preoperative Serum C- Reactive Protein, Neutrophil-lymphocyte Ratio and Platelet-lymphocyte Ratio for Cervical Metastasis in Patients of Primary Oral Squamous Cell Carcinoma

Abstract

Background: The influence of cervical metastasis on prognosis in a person who is suffering from oral squamous cell carcinoma (OSCC) has been notorious. C- reactive protein (CRP) is a prior biomarker for inflammation. Recent literature provide evidence of systemic inflammatory markers playing important role in determining survival rate on patient with OSCC. Hence, in current study the “utility of Neutrophil-lymphocyte ratio (NLR) ,Platelet-lymphocyte ratio (PLR), and serum CRP are evaluated and correlated for cervical metastasis”.
 Objectives: This study intends to evaluate and correlate preoperative serum CRP, NLR, and PLR for cervical metastasis in patients of primary oral squamous cell carcinoma.
 Methodology: The clinicopathological data, CRP and the preoperative complete blood investigation details were obtained from 40 primary OSCC patients who will undergo surgery. The optimal cut-off value of CRP, PLR and NLR was determined. The prognostic significance of markers will be determined by Univariate and multivariate analysis.
 Expected Results: The elevation of CRP, NLR, and PLR levels will significantly evaluate and correlate with cervical metastasis.
 Conclusion: Preoperative serum CRP, NLR, and PLR level will be a prognosticator in OSCC.

Progress of peripheral blood immunoinflammatory markers in oral squamous cell carcinoma

“…Among the etiologies of malignant neoplasia, chronic inflammation has been identified as the main cause of about 20% of malignant neoplasia cases [32].Although CRP is an egg self that reflects the acute response of the body, it has been shown that CRP levels also reflect the body's early defense system [33]. The potential predictive value of CRP in OSCC lymph node metastasis has been demonstrated in a prospective study of 40 OSCC patients [34]. This calls for a large number of prospective studies to further understand the potential value of CRP in assessing OSCC progression as well as the mechanisms.…”