Evaluation and Comparison of the Effects of Hyperbaric Oxygen and Ozonized Oxygen as Adjuvant Treatments in an Experimental Osteomyelitis Model

Oğuz, Erbil; Ekinci, Şafak; Eroğlu, Murat; Bïlgïç, Serkan; Koca, Kenan; Durusu, Murat; Kaldirim, Umit; Sadir, Serdar; Yurttaş, Yüksel; Çakmak, Gökhan; Kılıç, Abdullah; Purtuloglu, Tarik; Özyürek, Selahattin; Çekli, Yavuz; Özkan, Hüseyin; Şehirlioğlu, Ali

doi:10.1016/j.jss.2011.06.029

Cited by 23 publications

(13 citation statements)

References 35 publications

(44 reference statements)

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“…These compounds are chemically unstable and subsequently decompose to more stable MDA and other aldehydes, which can be toxic to osteoblasts [24]. Moreover, oxidative stress markers were increased at the time of diagnosis of OM in previous studies [10, 25–27], and our results confirm these reports. We also observed that hydroperoxides levels were normalized after 2nd week of treatment, whilst MDA was still above control values at discharge, particularly in subacute OM group, indicating that the intensity of oxidative stress could be related to the clinical course and complications of disease.…”

Section: Discussionsupporting

confidence: 89%

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Grbić¹,

Mirić²,

Kisic³

et al. 2014

Mediators of Inflammation

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In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress. Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability. The physiological functions of vitamin C largely depend on its redox status. We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM). Compared to 52 healthy controls, in OM group baseline serum hydroperoxides, MDA and oxidized/reduced vitamin C ratio were higher whilst Asc and AOA were lower (P < 0.05, resp.). On the other side, total vitamin C levels in patients and controls were similar (P > 0.05), thereby suggesting a relative rather than absolute vitamin C deficiency in OM. During the follow-up, oxidative stress markers, AOA, and oxidizedreduced vitamin C ratio were gradually returned to normal, while there was no apparent change of total vitamin C concentrations. Persistently high values of oxidized/reduced vitamin C ratio and serum MDA were found in subacute OM. In conclusion, acute OM was associated with enhanced systemic oxidative stress and the shift of vitamin C redox status towards oxidized forms.

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Section: Discussionsupporting

confidence: 89%

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Grbić¹,

Mirić²,

Kisic³

et al. 2014

Mediators of Inflammation

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“…The present study also showed that polymyxin E not only decreased the level of MDA, but also reduced the activity of SOD in serum of piglets, which might be a result of the immunosuppression activity of antibiotics. 43,44 The results were also supported by those of a study by Oguz et al 45 suggesting that antibiotics (vancomycin) could lower the levels of MDA and SOD in bone tissue. GSH-Px in the liver was higher in piglets fed polymyxin E diets compared to the control in the present study, which might be because antioxidant responses were stimulated after exposure to antibiotics.…”

Section: Cholesterol Metabolismsupporting

confidence: 73%

Phytosterols on growth performance, antioxidant enzymes and intestinal morphology in weaned piglets

Zhang

et al. 2017

J Sci Food Agric

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“…When the literature was examined, we found several animal models using tigecycline, vancomycin and HBO against MRSA, so we aimed to use these antibiotics and HBO. However, we did not discover any rat model involving the combined use of tigecycline and HBO [ 15 , 20 - 22 ] . Tigecycline was first derived from minocycline, and is a broad spectrum antibiotic of the glycylcycline class with broad in vitro activity [ 23 , 24 ] .…”

Section: Discussionmentioning

confidence: 99%

Adjunctive hyperbaric oxygen therapy or alone antibiotherapy? Methicillin Resistant staphylococcus aureus mediastinitis in a rat model

Kurt¹,

Vural²,

Temız³

et al. 2015

Brazilian Journal of Cardiovascular Surgery

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OBJECTIVE In the post-sternotomy mediastinitis patients, Staphylococcus aureus is the pathogenic microorganism encountered most often. In our study, we aimed to determine the efficacy of antibiotic treatment with vancomycin and tigecycline, alone or in combination with hyperbaric oxygen treatment, on bacterial elimination in experimental S. aureus mediastinitis.METHODS Forty-nine adult female Wistar rats were used. They were randomly divided into seven groups, as follows: non-contaminated, contaminated control, vancomycin, tigecycline, hyperbaric oxygen, hyperbaric oxygen + vancomycin and hyperbaric oxygen + tigecycline. The vancomycin rat group received 10 mg/kg/day of vancomycin twice a day through intramuscular injection. The tigecycline group rats received 7 mg/kg/day of tigecycline twice a day through intraperitoneal injection. The hyperbaric oxygen group underwent 90 min sessions of 100% oxygen at 2.5 atm pressure. Treatment continued for 7 days. Twelve hours after the end of treatment, tissue samples were obtained from the upper part of the sternum for bacterial count assessment.RESULTS When the quantitative bacterial counts of the untreated contaminated group were compared with those of the treated groups, a significant decrease was observed. However, comparing the antibiotic groups with the same antibiotic combined with hyperbaric oxygen, there was a significant reduction in microorganisms identified (P<0.05). Comparing hyperbaric oxygen used alone with the vancomycin and tigecycline groups, it was seen that the effect was not significant (P<0.05).CONCLUSION We believe that the combination of hyperbaric oxygen with antibiotics had a significant effect on mediastinitis resulting from methicillin-resistant Staphylococcus aureus. Methicillin-resistant Staphylococcus aureus mediastinitis can be treated without requiring a multidrug combination, thereby reducing the medication dose and concomitantly decreasing the side effects.

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Evaluation and Comparison of the Effects of Hyperbaric Oxygen and Ozonized Oxygen as Adjuvant Treatments in an Experimental Osteomyelitis Model

Cited by 23 publications

References 35 publications

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Sequential Analysis of Oxidative Stress Markers and Vitamin C Status in Acute Bacterial Osteomyelitis

Phytosterols on growth performance, antioxidant enzymes and intestinal morphology in weaned piglets

Adjunctive hyperbaric oxygen therapy or alone antibiotherapy? Methicillin Resistant staphylococcus aureus mediastinitis in a rat model

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