Evaluation and comparison of protective actions resveratrol and vitamin-e in 5-flourouracil induced hepatotoxicity

Harish, Belgode Narasimha; Shivakumar, Pabbathi; Kumar, Bdp Kala; Ramya, B; Rani, Munuswamy Usha; Kumar, B Anil; Kv, Venkata Rao

doi:10.22271/tpi.2021.v10.i3a.5931

Cited by 2 publications

(3 citation statements)

References 9 publications

(10 reference statements)

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“…It might be caused by an excess production of free radicals and oxidation products in the liver, which cause damage to the membranes and endothelial lining of the hepatic vessels, resulting in liver dysfunction and a change in the permeability of the hepatocytes cell membrane, allowing them to enter into the bloodstream (Dimitriu et al, 2015). A significant elevation of these enzyme activities has been used as an indicator of acute liver injury in agreement with the observations of Afolabi and Harish with an increase in the concentration of serum enzymes by administering 5- Ameliorative Effect of Naringenin in 5-Fluorouracil-Induced Hepatotoxicity: An Experimental Study on Albino Wistar Rats FU (Harish et al, 2021;Tavakoli Pirzaman et al, 2023). In the present study, 5-FU might have suppressed the growth of cellular proteins and RNA synthesis, resulting in a low level of serum proteins due to oxidative stress.…”

Section: Immunoexpression Of Nf-кb and Caspaes-3supporting

confidence: 72%

“…In the present study, 5-FU might have suppressed the growth of cellular proteins and RNA synthesis, resulting in a low level of serum proteins due to oxidative stress. ROS may induce inflammation, causing protein damage and lowering the ability of the liver to synthesize new proteins, leading to decrease in these values as report by Badawoud and Harish, who stated that 5-FU caused a decrease a in TP due to oxidative stress in liver (Badawoud et al, 2017;Harish et al, 2021).…”

Section: Immunoexpression Of Nf-кb and Caspaes-3mentioning

confidence: 94%

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Ameliorative Effect of Naringenin in 5-Fluorouracil-Induced Hepatotoxicity: An Experimental Study on Albino Wistar Rats

Vemula,

Mylaram,

Yadala

et al. 2024

IJAR

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Background: Hepatotoxicity is an adverse complication in 5-Fluorouracil cancer treatment. Inflammation, oxidative stress, apoptosis and DNA damage are essential in the pathogenesis of liver damage. The present study evaluated the ameliorative effect of Naringenin (NG) in 5-FU at two different intervals in hepatic damage. Methods: Total (n=48) Albino Wistar rats were divided into 4 groups (N=12), Control-normal saline (group-1) per oral, 5-FU (group-2) @ 20 mg/kg b.wt was injected intraperitoneal (IP) for first 5 days, NG (group-3) @100 mg/kg b. wt/day orally for 28 days. Another group-4 was concurrently treated with NG along with 5-FU for 28 days and sacrificed on the 14th and 28th day of the experiment. Result: On exposure to 5-FU, biochemical variation of liver enzymes (ALT, AST, ALP and TP) were significantly increased while NG treatment significantly reduced these biomarkers in group 2 on 14th day and 28th day of the experiment. Furthermore, NG treatment significantly reduced lipid peroxidation and increases the antioxidant profile. It also significantly reduced elevated concentrations of pro-inflammatory cytokines like tumour necrosis factor (TNF-α), interleukin -1β (IL-1β), interleukin-6 (IL-6) with increased concentrations of interleukin-10 (IL-10) along with reduced immunohistochemical expression of nuclear factor kappa light chain enhancer of activated B cells (NF-κB) and Caspases -3 (Cas-3) by NG. On histopathology, pathological lesions were observed to support biochemical variations in group-2 rats. In group-4 rats, NG ameliorates liver enzymes, inflammatory cytokines and oxidative indices through an anti-oxidant, anti-inflammatory and anti-apoptotic property.

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Section: Immunoexpression Of Nf-кb and Caspaes-3supporting

confidence: 72%

Section: Immunoexpression Of Nf-кb and Caspaes-3mentioning

confidence: 94%

Ameliorative Effect of Naringenin in 5-Fluorouracil-Induced Hepatotoxicity: An Experimental Study on Albino Wistar Rats

Vemula,

Mylaram,

Yadala

et al. 2024

IJAR

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show abstract

“…This finding is consistent with a previous report (Helal and Said, 2020;Namratha et al, 2021) that showed marked liver injury in rats treated with MTX. Similarly other authors also deomonstrated that protective effect of resveratrol and vitamin-e in 5-flourouracil induced hepatotoxicity (Harish et al, 2021), Terminalia arjuna against Experimental Hepatotoxicity due to Cisplatin in Rats (Sneha et al, 2021) and postulated protective effects due to antioxidant properties of these plants. However, our study also found that the administration of B. monnieri, which has antioxidant properties, significantly reversed the changes in serum AST and ALT activities in the toxic control group.…”

Section: Histopathology Of Livermentioning

confidence: 82%

Protective effect of Bacopa monnieri against Methotrexate induced Hepatotoxicity in Wistar rats

Tummala,

Banothu,

Kumar

et al. 2023

IJAR

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Background: Methotrexate (MTX) is an anticancer drug and its clinical efficacy is limited to the toxicity associated with the liver. In this study, we examine the potential role of aqueous leaf extracts of Bacopa monnieri to counter methotrexate-induced hepatotoxicity. Methods: This study was undertaken by considering 36 numbers. Wistar male rats were randomly segregated into six groups, with six rats per group. Groups 1 and 2 were kept as normal controls and methotrexate was treated on the 9th day. While groups 3 and 4 received an aqueous extract of the leaf of B. monnieri at two varied doses of 150 and 300 mg/kg, respectively, as a treatment, Whereas groups 5 and 6 kept B. monnieri perse and the standard hepatoprotective drug silymarin @ 200 mg/kg and experiment was conducted for 14 days period. After the experimental procedure, AST, ALT, TNF-á and IL-10 were measured and histopathology of the liver was done. Result: The present study revealed significant alterations in AST, ALT, TNF-alfa and IL-10 in methotrexate-treated rats (group 2) when compared to group 1 and treatment groups 4 and 5 revealed significant improvement and these results were validated through imaging in the histopathology of the liver. We conclude that Bacopa monnieri can efficiently reduce methotrexate-induced liver inflammation and can be used in the management of hepatotoxicity in the liver.

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Evaluation and comparison of protective actions resveratrol and vitamin-e in 5-flourouracil induced hepatotoxicity

Cited by 2 publications

References 9 publications

Ameliorative Effect of Naringenin in 5-Fluorouracil-Induced Hepatotoxicity: An Experimental Study on Albino Wistar Rats

Ameliorative Effect of Naringenin in 5-Fluorouracil-Induced Hepatotoxicity: An Experimental Study on Albino Wistar Rats

Protective effect of Bacopa monnieri against Methotrexate induced Hepatotoxicity in Wistar rats

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