Evaluation and clinical significance of cyclin-dependent kinase5 expression in cervical lesions: a clinical research study in Guangxi, China

Abstract

BackgroundStudies have been reported that cyclin-dependent kinase5 (CDK5) was associated with the development of several cancers. However, the relationship between CDK5 level and clinicopathological factors is still poorly understood in cervical diseases. The aim of the current study was to investigate the expression of CDK5 and its clinical significance in variant cervical lesions.MethodsImmunohistochemistry (IHC) was used to detect CDK5 expression in 54 cases of chronic cervicitis, 42 cases of condyloma acuminate (CA), 38 cases of carcinoma in situ, and 360 cases of cervical cancers [adenocarcinoma, n = 63; squamous cell carcinoma (SCC), n = 263; adenosquamous carcinoma, n = 34]. The clinicopathological characteristics in relation to CDK5 were examined by Pearson’s Chi-square test.ResultsThe positive rates of CDK5 were 27.8, 31.0, 50, 54.0, 58.8, and 62.7 % in chronic cervicitis, CA, carcinoma in situ, adenocarcinoma, adenosquamous carcinoma and SCC, respectively. Statistically analysis showed that CDK5 expression in cervical cancer tissues was higher than non-cervical cancer tissues (inflammation and CA) (P < 0.001). The overexpression of CDK5 was significantly correlated with lymph node metastasis (r = 0.317; P < 0.001), histological type (r = 0.198; P < 0.001), FIGO stage (r = 0.358; P < 0.001), TNM stage (r = 0.329; P < 0.001) and pathological grade (r = 0.259; P < 0.001) in cervical lesions evaluated by Pearson’s Chi-square test. Furthermore, the positive relationships were found between CDK5 and lymph node metastasis (P < 0.001), FIGO stage (P < 0.001), TNM stage (P < 0.001) and pathological grade (P < 0.001) in SCC. CDK5 was positively interrelated to TNM stage (P = 0.017) in adenosquamous carcinoma.ConclusionsCDK5 may play a vital role in the development of cervical cancer, which may be a marker for the diagnosis, therapy and prognosis of cervical cancer.

Immune system‑associated genes increase malignant progression and can be used to predict clinical outcome in patients with hepatocellular carcinoma

“…Although CDK5 shares homologous structure with other CDKs, it is not cyclin-dependent and does not need to be phosphorylated in the T-loop for activation (66). CDK5 expression is upregulated in several types of cancer, and inhibition induces cancer cell death through a FOXO1-Bim pathway or mitochondrial dysfunction (67)(68)(69)(70)(71)(72)(73). Ehrlich et al (74) showed that expression of CDK5 was increased in HCC tissues, and was correlated with malignant phenotypes.…”

CDK5 inhibition in�vitro and in vivo induces cell death in�myeloma and overcomes the obstacle of bortezomib resistance

“…Previous studies showed that aberrant expression of CDK5 had been observed in multiple human cancers, but not in normal tissues. CDK5 were positively correlated with lymph node metastasis and the stage of disease in head and neck squamous cell carcinoma, cervical lesions, lung cancer, hepatocellular carcinoma and nasopharyngeal carcinoma (5)(6)(7)(8)(9)(10), and its overexpression was also associated with the poor prognosis in colorectal cancer and breast cancer (7,8). Tumor tissues with high expression of cdK5 are usually insensitive to chemoradiotherapy and targeted therapy (11,12).…”