Evaluation and Active Treatment versus Active Surveillance of Localized Prostate Cancer in Renal Transplant Patients in the Era of Low and Very Low Risk Prostate Cancer

Aminsharifi, Alireza; Simon, Ross; Robertson, Cary N.; Sudan, Debra L.; Collins, Bradley H.; Moul, Judd W.

doi:10.1097/ju.0000000000000207

Cited by 21 publications

(22 citation statements)

References 32 publications

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“…Notably, a non-negligible option in PCa treatment -especially in the last years- is represented by AS. As reported by Aminsharifi et al Current trends in renal transplantation, such as improved allograft/recipient survival and expanded organ transplantation eligibility criteria in older recipients, are concomitant with increasingly detected low risk prostate cancer in candidates for or recipients of renal transplantation ( 41 ). Thus, the role of AS protocol in RTR and the incorporation of modern imaging modalities to better select active surveillance candidates remain a clinical unmet need which may prevent overtreatment in such complex cases.…”

Section: Discussionmentioning

confidence: 99%

Prostate Cancer Characteristics in Renal Transplant Recipients: A 25-Year Experience From a Single Centre

et al. 2021

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Objectives: The incidence of prostate cancer in renal transplant recipients (RTRs) is increasing, but few data are available in the literature. In this study, we reviewed the 25-year experience in the management of prostate cancer after kidney transplantation at the Florence Transplant Centre.Methods: We retrospectively reviewed the data from 617 RTR male patients who underwent renal transplantation at our institute between July 1996 and September 2016. Data regarding demographics, renal transplantation, prostate cancer and immunosuppressive treatment were analyzed. The probability of death was estimated by using the Kaplan-Meier method and differences between patients' groups were assessed by the log-rank test.Results: From July 1991 to September 2016, 617 kidney transplantations of male patients were performed at our institute. Among these, 20 patients were subsequently diagnosed with prostate cancer accounting for a cumulative incidence of 3.24%. After a median follow-up of 59 months, 10 patients underwent radical prostatectomy whereas 10 patients underwent primary radiotherapy. A biochemical recurrence was identified in five (25%) patients while a fatal event occurred in 11 (55%) patients. Univariate Cox regression showed that the basal value of PSA >10 ng/ml was the only significant factor negatively affecting the survival of patients.Conclusions: Standard treatments can be proposed to RTR with satisfactory results on both post-operative and oncological outcomes. Further studies are needed to address the issue of prostate cancer screening based on PSA levels and the optimal management of prostate cancer in RTRs.

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Section: Discussionmentioning

confidence: 99%

Prostate Cancer Characteristics in Renal Transplant Recipients: A 25-Year Experience From a Single Centre

et al. 2021

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“…[20][21] This is because localised PCa cells feature less proliferative activity and they do not usually metastasise. 22 The determination of the histological variants of PCa cells is important for the diagnostic recognition of cancer and therapeutic significance of the cancer treatment. 23 The findings reveal that adenocarcinoma is the major histopathological type of PCa among Saudis (88%).…”

Section: Discussionmentioning

confidence: 99%

Prostate cancer in Saudi Arabia: trends in incidence, morphological and epidemiological characteristics

Alshehri

2020

Int J Res Med Sci

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Background: Prostate cancer (PCa) is the second most common cause of cancer and the second leading cause of cancer death among men worldwide. This paper aims to determine the incidence of the prostate cancer cases in Saudi Arabia between 1994 and 2016.Methods: In this study, the statistics of prostate cancer cases recorded in reports of the Saudi cancer registry for the period from 1994 to 2016 are used. The data and numbers of these reports were assessed to review the full picture during the study period. Age-standardized and age-specific incidence rates were calculated for these purposes.Results: In total, 89,880 cancer cases were recorded for the period between 1994 and 2016. The number of prostate cancer cases out of this total is 5,332. The age-adjusted prostate cancer incidence increased from 4.1 in 1994 to 6.3 in 2016. A variation in the incidence of prostate cancer by region was noticed, and a direct relationship was identified between prostate cancer rates and the ages of those with prostate cancer, with the majority of people with prostate cancer being over 50 years.Conclusions: The overall appearance of prostate cancer is moving upwards. Differences in the incidence rates between men who live in different Saudi regions suggest that environment, behaviour and genetic factors may be a cause. Exploring these factors is necessary to take advantage of them while drawing up the prevention plans.

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“…Similarly brachytherapy and external beam radiation have been found to have equivalent outcomes in a recent series [65] though there is always a concern for increased incidence of radiation related allograft complications [61]. With the increased detection of low risk www.tridhascholars.org | June-2020 cancers the role of active surveillance and focal therapy are also being explored [65,66] and need further evidence to support their routine usage, though in carefully selected men, may be safe. Hormonal treatment has been employed in conjunction with radiation therapy, however, literature on the management of BCR and metastatic disease in this population is lacking especially with the metamorphosis of current therapeutics and the possible role of immunotherapy.…”

Section: Prostate Cancermentioning

confidence: 99%

De-Novo Genitourinary Neoplasms in Transplant Recipients: The Present and Future

Subodh¹,

Jiang²,

Christopher³

2020

Cancer Med J

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The risk of genitourinary cancers following transplantation is increased following majority of solid organ transplants but is best described following renal transplantation. Increasing average age of the transplant recipient as well as increases in post- transplant survival increases the risk of these malignancies. The risk of Kidney cancer is the highest following most solid organ transplants, whereas prostate cancer risk is lower than the general population in multiple large population-based studies. The etiology of increased risk of cancer following transplant is multifactorial with the predominant influence of immunosuppression and direct toxicity of immunosuppressants, however, the significance of end stage disease particularly in the causation of renal cancer in renal transplant recipients is undeniable. Modifications in immunosuppression regimens as well as changes in the standard treatment principles of some cancers may require changes in the management of some post-transplant malignancies. Standard screening guidelines have not been established but screening for renal tumors in renal transplant recipients is the only widely studied entity. Further work is needed to prepare the urologic oncological community with this once rare population group and standardized recommendations need to be established for screening and for the use of new age cancer therapeutics like immunotherapy.

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Evaluation and Active Treatment versus Active Surveillance of Localized Prostate Cancer in Renal Transplant Patients in the Era of Low and Very Low Risk Prostate Cancer

Cited by 21 publications

References 32 publications

Prostate Cancer Characteristics in Renal Transplant Recipients: A 25-Year Experience From a Single Centre

Prostate Cancer Characteristics in Renal Transplant Recipients: A 25-Year Experience From a Single Centre

Prostate cancer in Saudi Arabia: trends in incidence, morphological and epidemiological characteristics

De-Novo Genitourinary Neoplasms in Transplant Recipients: The Present and Future

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