Evaluation & Comparison of Single Dose Oral Treatment of Uncomplicated Gonococcal Urethritis in Males with Talampicillin & Minocycline

Abstract

A comparison has been made of the relative efficiency of Talampicillin and Minocycline given as single doses orally in the treatment of uncomplicated acute gonococcal urethritis in the male. One hundred and fifteen patients were given Talampicillin I.5Gm and of these II (9.6010) defaulted and were excluded. One hundred and thirty eight patients received 300mg Minocycline and of these 12 (8.7%) defaulted and were excluded. In the Talam-piciIIin group 8.7010 were presumed treatment failures whereas in the Minocycline group the figure was 3.2%.It is considered that single dose oral Talampicillin used alone gives disappointingly high failure rates in the treatment of acute gonorrhoea. Minocycline in single oral dosage remains a suitable and effective drug in the treatment of acute gonococcal urethritis. In this trial both drugs were free from side effects.