Evaluating Vitamin D and foxp3 mRNA levels in women with recurrent spontaneous abortion

Tafti, Fatemeh Dehghani; Zare, Fateme; Miresmaeili, Seyed Mohsen; Fesahat, Farzaneh

doi:10.5935/1518-0557.20210062

Cited by 2 publications

(17 citation statements)

References 34 publications

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“…Fourteen studies 11–24 were included with serum vitamin D levels as a continuous variable. Twelve studies 11–16,18,19,21–24 were included with serum vitamin D levels as a dichotomous variable. Meta‐analysis of the random effects model showed RSA patients had lower vitamin D levels during pregnancy than controls ( SMD = ‐1.48, 95% CI : ‐2.01, ‐.94, P < .001), and pregnant women with VDD had a higher risk of developing RSA than pregnant women with normal vitamin D ( OR = 4.02, 95% CI : 2.23, 7.25, P < .001).…”

Section: Resultsmentioning

confidence: 99%

“…Serum vitamin D levels were lower in the RSA group than in the control group when serum vitamin D levels were measured by CM ( SMD = ‐1.63, 95% CI : ‐2.36, ‐.91, P < .001) and ELISA ( SMD = ‐2.06, 95% CI : ‐3,.96 ‐.15, P = .034). In addition, a total of 12 studies 11–16,18,19,21–24 were included with serum vitamin D levels as a dichotomous variable. There was no significant association between VDD and RSA in pregnant women when serum vitamin D levels were measured by LC‐MS/MS ( OR = 1.71, 95% CI : .08, 38.48, P = .737) or other methods.…”

Section: Resultsmentioning

confidence: 99%

“…10 However, considerable heterogeneity in the association between serum vitamin D and RSA was observed. [11][12][13][14][15][16][17][18][19][20][21][22][23][24] The aim of this review is to conduct a systematic synthesis and a metaanalysis of the evidence for the association between serum vitamin D levels and RSA.…”

Section: Introductionmentioning

confidence: 99%

“…Subgroup analyses were performed by different regional origins of the populations, and 14 studies[11][12][13][14][15][16][17][18][19][20][21][22][23][24] were included with serum vitamin D levels as a continuous variable. The subgroup analyses were all performed using a random effects model because of the significant heterogeneity.…”

mentioning

confidence: 99%

“…The results were shown in Figure4.The subgroup analysis was performed by whether the average age of the population was ' > 35' . There were 11 studies[11][12][13][14][15][16]19,20,[22][23][24] TA B L E 1 †Testing methods: LC-MS/MS: Liquid chromatograph-mass spectrometer. CM: Chemiluminescence method.…”

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confidence: 99%

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Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

Chen

Wang

Zhang

et al. 2022

American J Rep Immunol

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Problem Previous studies had shown that there might be an association between serum vitamin D concentrations and the occurrence of recurrent spontaneous abortion (RSA). However, the conclusions remained controversial. The objective of this study was to systematically review the evidence for an epidemiological association between vitamin D and RSA. Method of study The literature search was performed in the following databases: PubMed, Web of Science, Embase and Chinese databases. The I2 statistic was used to evaluate heterogeneity. Effect sizes were calculated using fixed or random effects models, including standardized mean difference (SMD), odds ratios (OR) and their 95% confidence intervals (95% CI). Then, we performed subgroup analysis, sensitivity analysis and publication bias analysis. Results Fourteen studies from five countries were included. Based on the results, patients with RSA had lower vitamin D levels than controls (SMD = ‐1.48, 95% CI: ‐2.01, ‐.94, P < .001), and pregnant women with vitamin D deficiency (VDD) had a higher risk of developing RSA (OR = 4.02, 95% CI: 2.23, 7.25, P < .001). There was remarkable heterogeneity between studies (I2SMD = 97.3%, P < .001; I2OR = 82.2%, P < .001). The results of the subgroup analysis suggested that heterogeneity may be caused by the assay method, age and region. Sensitivity analysis showed the analysis results were robust. Conclusion Patients with RSA had lower serum vitamin D levels than normal pregnant women, and pregnant women with VDD might be at higher risk for RSA.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

Chen

Wang

Zhang

et al. 2022

American J Rep Immunol

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Recurrent Pregnancy Loss Etiology, Risk Factors, Diagnosis, and Management. Fresh Look into a Full Box

Turesheva,

Aimagambetova,

Ukybassova

et al. 2023

JCM

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Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. Inconsistency in definitions involves not only the number of spontaneous abortions (two or three) that are accepted for recurrent pregnancy loss but the types of pregnancy and gestational age at miscarriage. Due to the heterogeneity of definitions and criteria applied by international guidelines for recurrent pregnancy loss, the true incidence of recurrent miscarriage, which is reported to range from 1% to 5%, is difficult to estimate. Moreover, the exact etiology of recurrent pregnancy loss remains questionable; thus, it is considered a polyetiological and multifactorial condition with many modifiable and non-modifiable factors involved. Even after thoroughly evaluating recurrent pregnancy loss etiology and risk factors, up to 75% of cases remain unexplained. This review aimed to summarize and critically analyze accumulated knowledge on the etiology, risk factors, relevant diagnostic options, and management approach to recurrent pregnancy loss. The relevance of various factors and their proposed roles in recurrent pregnancy loss pathogenesis remains a matter of discussion. The diagnostic approach and the management largely depend on the etiology and risk factors taken into consideration by a healthcare professional as a cause of recurrent miscarriage for a particular woman or couple. Underestimation of social and health consequences of recurrent pregnancy loss leads to compromised reproductive health and psychological well-being of women after miscarriage. Studies on etiology and risk factors for recurrent pregnancy loss, especially idiopathic, should be continued. The existing international guidelines require updates to assist clinical practice.

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Evaluating Vitamin D and foxp3 mRNA levels in women with recurrent spontaneous abortion

Cited by 2 publications

References 34 publications

Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

Association between serum vitamin D level during pregnancy and recurrent spontaneous abortion: A systematic review and meta‐analysis

Recurrent Pregnancy Loss Etiology, Risk Factors, Diagnosis, and Management. Fresh Look into a Full Box

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