Evaluating tranexamic acid for the prevention and treatment of obstetric hemorrhage
John J. Kowalczyk,
Maurizio Cecconi,
Alexander J. Butwick
Abstract:Purpose of review
Tranexamic acid (TXA) has emerged as a promising pharmacological adjunct to treat and prevent postpartum hemorrhage (PPH). We provide an overview of TXA, including its pharmacology, key findings of randomized trials and observational studies, and critical patient safety information.
Recent findings
Pharmacokinetic data indicate that TXA infusions result in peak plasma concentration within 3 min (range: 1–6.6 min). Ex-vivo pharmacodynam… Show more
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