Evaluating Tonsillectomy as a Risk Factor for Childhood Obesity

Levi, Jessica R.; Leoniak, Steven; Schmidt, Richard

doi:10.1001/2013.jamaoto.252

Cited by 26 publications

(31 citation statements)

References 15 publications

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“…Treatment of OSA (primarily T&A, but CPAP in one study) may improve leptin and possibly ghrelin levels, although again, data are somewhat contradictory 407. However, despite these favorable changes, treatment of OSA in children does not necessarily lead to weight loss; as in adults, a number of studies have reported post-T&A weight gain in children and adolescents,408,409 likely due to a reduction in energy expenditure during sleep as well as other hormonal changes. However, despite the weight gain, treatment of OSA may have favorable metabolic implications.…”

Section: Obstructive Sleep Apnea and Cardiometabolic Riskmentioning

confidence: 99%

Role of sleep quality in the metabolic syndrome

Koren¹,

Dumin²,

Gozal³

2016

DMSO

139

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Emerging evidence has assigned an important role to sleep as a modulator of metabolic homeostasis. The impact of variations in sleep duration, sleep-disordered breathing, and chronotype to cardiometabolic function encompasses a wide array of perturbations spanning from obesity, insulin resistance, type 2 diabetes, the metabolic syndrome, and cardiovascular disease risk and mortality in both adults and children. Here, we critically and extensively review the published literature on such important issues and provide a comprehensive overview of the most salient pathophysiologic pathways underlying the links between sleep, sleep disorders, and cardiometabolic functioning.

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Section: Obstructive Sleep Apnea and Cardiometabolic Riskmentioning

confidence: 99%

Role of sleep quality in the metabolic syndrome

Koren¹,

Dumin²,

Gozal³

2016

DMSO

139

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“…OSA is most prevalent in 2- to 8-year-old children, when tonsil and adenoid volume is largest relative to the upper airway diameter; these children are usually referred to adenotonsillectomy as the first-line treatment ( 1 , 3 , 6 , 15 , 32 ). A currently poorly understood phenomenon is the fact that treatment of OSA can lead to accelerated weight gain in children, i.e., it normalizes weight in children who have failure to thrive, but increases the risk for obesity in overweight patients ( 1 , 2 , 5 , 6 , 15 , 32 – 35 ). Regulation of energy expenditure is multifactorial and includes factors such as metabolic rate at rest, physical activity, and thermic effect of food intake ( 19 , 20 , 36 , 37 ).…”

Section: Introductionmentioning

confidence: 99%

Abnormal Growth and Feeding Behavior in Upper Airway Obstruction in Rats

Tarasiuk

Segev

2018

Front. Endocrinol.

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Pediatric obstructive sleep apnea (OSA) is a syndrome manifesting with snoring and increased respiratory effort due to increased upper airway resistance. In addition to cause the abnormal sleep, this syndrome has been shown to elicit either growth retardation or metabolic syndrome and obesity. Treating OSA by adenotonsillectomy is usually associated with increased risk for obesity, despite near complete restoration of breathing and sleep. However, the underlying mechanism linking upper airways obstruction (AO) to persistent change in food intake, metabolism, and growth remains unclear. Rodent models have examined the impact of intermittent hypoxia on metabolism. However, an additional defining feature of OSA that is not related to intermittent hypoxia is enhanced respiratory loading leading to increased respiratory effort and abnormal sleep. The focus of this mini review is on recent evidence indicating the persistent abnormalities in endocrine regulation of feeding and growth that are not fully restored by the chronic upper AO removal in rats. Here, we highlight important aspects related to abnormal regulation of metabolism that are not related to intermittent hypoxia per se, in an animal model that mimics many of the clinical features of pediatric OSA. Our evidence from the AO model indicates that obstruction removal may not be sufficient to prevent the post-removal tendency for abnormal growth.

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“…Algunos estudios han reportado un aumento del peso en pacientes sometidos a amigdalectomía, aparentemente por una mayor facilidad en la deglución de alimentos 37,38 , siendo aún objeto de controversia 39,40 . Lo anterior no fue observado en nuestros resultados, sin embargo nuestro seguimiento fue de sólo un año, por lo que desconocemos la evolución a futuro de estos pacientes.…”

Section: Discussionunclassified

Influencia del exceso de peso en el éxito de la adenoamigdalectomía en pacientes con hiperplasia adenoamigdalina sintomática

et al. 2018

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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Evaluating Tonsillectomy as a Risk Factor for Childhood Obesity

Cited by 26 publications

References 15 publications

Role of sleep quality in the metabolic syndrome

Role of sleep quality in the metabolic syndrome

Abnormal Growth and Feeding Behavior in Upper Airway Obstruction in Rats

Influencia del exceso de peso en el éxito de la adenoamigdalectomía en pacientes con hiperplasia adenoamigdalina sintomática

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