Evaluating three strategies of genome‐wide association analysis for integrating data from multiple populations
Zhanming Zhong,
Guangzhen Li,
Zhiting Xu
et al.
Abstract:In livestock, genome‐wide association studies (GWAS) are usually conducted in a single population (single‐GWAS) with limited sample size and detection power. To enhance the detection power of GWAS, meta‐analysis of GWAS (meta‐GWAS) and mega‐analysis of GWAS (mega‐GWAS) have been proposed to integrate data from multiple populations at the level of summary statistics or individual data, respectively. However, there is a lack of comparison for these different strategies, which makes it difficult to guide the best… Show more
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