Evaluating the Yield of Medical Tests

Harrell, Frank E.; Califf, Robert M.; Pryor, David B.; Lee, Kerry L.; Rosati, Robert A.

doi:10.1001/jama.1982.03320430047030

Cited by 2,713 publications

(1,556 citation statements)

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“…In both univariate and multivariate analyses for independent dichotomous variables, the putative better prognosis category was considered as the reference category. We evaluated the predictive capacity of the final model and the contribution of each variable to the predictive capacity itself by (Harrell et al, 1982). If the model has no predictive capacity (i.e.…”

Section: Discussionmentioning

confidence: 99%

Tissue carcinoembryonic antigen and oestrogen receptor status in breast carcinoma: an immunohistochemical study of clinical outcome in a series of 252 patients with long-term follow-up

Mauri¹,

Caffo²,

Veronese

et al. 1998

Br J Cancer

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Summary Carcinoembryonic antigen (CEA) is a well-known tumour marker whose immunohistochemical expression could be prognostically relevant in breast carcinomas. We evaluated CEA immunohistochemical expression, using the specific T84.66 monoclonal antibody, in a series of 252 consecutive cases of infiltrating breast carcinomas (104 NO, 148 N1/2) with median follow-up of 84 months. Oestrogen receptor (ER) status has been evaluated with the immunohistochemical method (ER1 D5 antibody, 10% cut-off value): 121 cases were ER negative, 128 cases were ER positive and in three cases ER status was unknown. CEA staining was cytoplasmic; staining intensity and percentage of reacting cells were combined to obtain a final score (CEA score). The difference between the distribution of CEA score within the modalities of the other variables was not statistically significant. Univariate survival analysis has been performed on the series of node-negative and node-positive patients. In the latter subgroup, this has been performed separately for patients treated with systemic adjuvant hormonal therapy or chemotherapy. A multivariate analysis was only performed for node-positive patients treated with adjuvant therapy. CEA immunoreactivity was not prognostically relevant in any subset of analysed patients. The most important prognostic markers were nodal status and tumour size.

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Section: Discussionmentioning

confidence: 99%

Tissue carcinoembryonic antigen and oestrogen receptor status in breast carcinoma: an immunohistochemical study of clinical outcome in a series of 252 patients with long-term follow-up

Mauri¹,

Caffo²,

Veronese

et al. 1998

Br J Cancer

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“…It is also the probability that a randomly chosen testpositive counselee will have a higher probability (or prediction score) of a BRCA mutation than a randomly chosen test-negative counselee (50,51), which implies a correct rank ordering of the 2 predictions. We computed the c-statistic by using all possible pairs of counselees, one of whom is positive and the other negative.…”

Section: Discussionmentioning

confidence: 99%

Validity of Models for Predicting BRCA1 and BRCA2 Mutations

2007

Ann Intern Med

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“…Two main factors contribute to perioperative risk, the first related to the type of surgery and degree of haemodynamic cardiac stress associated with surgery-specific techniques, the second related to patient characteristics 32 . In some cases, such as in vascular surgery for peripheral vascular disease, the two conditions coexists due to frequent co-morbidities (CAD, congestive heart failure, cerebrovascular disease, and renal and pulmonary disease) [67][68][69][70][71][72][73][74][75][76] . Considerable risk is also present when surgery is performed as an emergency procedure especially in the elderly.…”

Section: Preoperative Evaluation and Clinical Predictionmentioning

confidence: 99%

Perioperative myocardial infarction in non-cardiac surgery. Pathophysiology and clinical implications

2006

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Advances in surgical and anaesthetic techniques and an aging patient population have resulted in more complex procedures being performed in greater numbers of aged subjects and in patients with a high likelihood of significant cardiovascular disease. Nearly one fourth of non-cardiac surgical procedures (major intra-abdominal, thoracic, vascular, and orthopaedic procedures) performed in persons older than 65 years have been found to be associated with significant perioperative cardiovascular morbidity and mortality. During previous years the main attempt was to define strategies to accurately estimate perioperative cardiovascular risk based either on the characteristics of surgery and on patient characteristics. More recently preventive medical strategies have been proposed. Therefore, the physician has to be aware of the key elements useful to calculate the perioperative cardiovascular risk, and of the medical preventive treatment or further interventions to adopt in patients candidate to surgery.

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Evaluating the Yield of Medical Tests

Cited by 2,713 publications

References 10 publications

Tissue carcinoembryonic antigen and oestrogen receptor status in breast carcinoma: an immunohistochemical study of clinical outcome in a series of 252 patients with long-term follow-up

Tissue carcinoembryonic antigen and oestrogen receptor status in breast carcinoma: an immunohistochemical study of clinical outcome in a series of 252 patients with long-term follow-up

Validity of Models for Predicting BRCA1 and BRCA2 Mutations

Perioperative myocardial infarction in non-cardiac surgery. Pathophysiology and clinical implications

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