Evaluating the Serum and Seminal Plasma Levels of Zinc and Cadmium in Smokers and Their Relation to the Semen Parameters

Bazid, Heba A. S.; Attia, Abdalla M; Yousef, Amira Mohamed; Fawal, Asmaa N; Mostafa, Mohammed I.

doi:10.1007/s12011-021-02720-3

Cited by 9 publications

(13 citation statements)

References 38 publications

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“…Bazid и соавт. [26] достоверной корреляции уровня цинка в сперме с возрастом не выявлено, на наш взгляд, из-за недостаточного объема выборки (n=70). Полученный нами коэффициент корреляции оказался низким (r=-0,0984; p <0,001; n=486), но характеризовался достаточно высокой достоверностью, что подтверждает вывод о снижении с возрастом среднего уровня цинка в спермоплазме (см.…”

Section: Discussionunclassified

“…В ряде исследований установлена достоверная корреляция уровня цинка в спермоплазме только с количеством сперматозоидов [1, 19,24] (рис. 1), в то время как в работах других авторов показаны корреляции спермоплазменного уровня цинка с морфологией и подвижностью сперматозоидов, но не с количеством сперматозоидов [25] или только с подвижностью [26] (рис. 1б, в).…”

Section: обоснованиеunclassified

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Correlation of the zinc level in the spermoplasm with the fertility characteristics of human ejaculate

Lutsky

Lutskaya

Mahmudov

et al. 2023

Journal of Clinical Practice

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Background: Zinc is essential for the normal functioning of the male reproductive system. The data on the diagnostic value of the determination of zinc in human spermoplasm and the relationship of its level with the main parameters of sperm fertility are contradictory. Aims: Study of correlations of zinc level in spermoplasm with spermogram characteristics. Methods: Sperm of men of reproductive age (n=486, average age 33.073.03 years) was studied. In addition to the standard spermogram, MAR tests (IgA, IgG and IgM) were performed in the sperm samples, the degree of fragmentation of sperm DNA was assessed, the interaction of sperm with hyaluronic acid was assessed, acrosine activity, neutral alpha-glucosidase activity was determined, citric acid, fructose and glycodelin levels were determined, the level of reactive oxygen species was studied. Determination of the zinc level in the spermoplasm was carried out by a standard spectrophotometric method with 5-Br-PAPS chromogen. Pearson's formula was used for correlation analysis. The study was conducted from 2018 to May 2022, once. Results: A significant negative correlation of the zinc level in the spermoplasm with the age of men was revealed (r=-0.1625, p0.001). The level of zinc in the spermoplasm was weakly negatively correlated with the dilution time and with the viscosity of the sperm. The positive correlation was with the number of spermatozoa (r=0.1345, p0.01) and their mobility (r=0.3825, p0.00001). The level of zinc in the spermoplasm negatively correlates with the degree of fragmentation of sperm DNA and with the amount of reactive oxygen species, and with the test for binding of sperm with hyaluronic acid positively. Conclusions: The level of zinc in the spermoplasm significantly correlates with a number of physiological and biochemical characteristics of sperm. The data obtained allow us to recommend the determination of zinc in the sperm plasma not only to assess the functional activity of the prostate gland, but also to diagnose the fertility of the ejaculate, as well as to optimize therapy with zinc-containing drugs and improve control over the effectiveness of the treatment.

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Section: Discussionunclassified

Section: обоснованиеunclassified

Correlation of the zinc level in the spermoplasm with the fertility characteristics of human ejaculate

Lutsky

Lutskaya

Mahmudov

et al. 2023

Journal of Clinical Practice

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“…The reason may be that young participants often show less healthy eating habits than general participants ( 36 , 37 ). In addition, smoking can have a harmful effect on semen quality through a variety of toxic substances and chemical substances ( 38 ). However, the beneficial substances produced by diet cannot compensate for the harm to semen quality caused by smoking, which may explain the negative correlations between the CHEI score and asthenoteratozoospermia risk in non-smokers.…”

Section: Discussionmentioning

confidence: 99%

Diet Quality Scores and Asthenoteratozoospermia Risk: Finding From a Hospital-Based Case–Control Study in China

Cui

Wang

et al. 2022

Front. Nutr.

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ObjectiveWe aimed to examine associations of diet quality scores, including the dietary approaches to stop hypertension (DASH), alternate Healthy Eating Index (AHEI), and Chinese Healthy Eating Index (CHEI) with asthenoteratozoospermia risk in China.MethodsAmong 254 cases and 633 controls in a hospital-based case–control study in Shenyang, Liaoning Province, China, DASH, AHEI, and CHEI were calculated using a validated food frequency questionnaire. Asthenotetrazoospermia was evaluated according to World Health Organization guidelines. Unconditional multiple logistic regression was used to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for the association between quality diet scores and asthenoteratozoospermia risk.ResultsWe found that the CHEI score was inversely associated with asthenoteratozoospermia risk, with ORs of 0.59 (95% CI 0.39, 0.88) and 0.59 (95% CI 0.39, 0.88) for the 2nd and 3rd tertiles vs. the 1st tertile, respectively (P trend < 0.05). In addition, our data indicated that each standard deviation increase in CHEI, AHEI-2010, and DASH score was associated with 19, 13, and 17% decreased risk of asthenoteratozoospermia, respectively.ConclusionOur findings suggest that higher adherence to the CHEI, AHEI-2010, and DASH diet quality scores may reduce the risk of asthenoteratozoospermia, especially for younger participants.

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“…a detailed history and physical examination were done on both couples. The sperm count was used to group the infertile subjects oligospermia (35), and azoospermic (15). The subjects hada sperm count of less than 20 million/ml tooksperm while azoospermichad0 sperm count.…”

Section: Methodsmentioning

confidence: 99%

Association of Zinc Concentration in Seminal Plasma and Blood with Several Parameters of Semen in Infertile Males

Saeedullah¹,

Shah²,

Hakim³

et al. 2022

PJMHS

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Objective: To evaluate the concentration of zinc inthe blood and seminal plasma with semen parameters between fertile and infertile males Methodology: This prospective study was carried out in the Department of Biochemistry, Hayatabad medical complex, Peshawar. Fifty (50)infertile males, not receiving any treatment and had regularintercourse for 1 yearaged 25-45 years were selected from HMC. They were divided into 35oligospermia and 15 azoospermic. 35 fertile males were nominatedamongthe overallresidents and were taken as the control group after their semen analysis was taken as normozoospermic. According to WHO criteria semen is analyzed. With the help of 5br Serum and seminal plasma zinc were estimated. Result: There was a significant difference found in serum and seminal levels of zinc in normozoospermic, oligospermia (p less than 0.05), and azoospermic (p-value less than 0.05) individuals. The correlation of seminal plasma zinc with sperm counts showed a positive association with the count of sperm and a negative association with motility of sperm in normozoospermic/oligospermia and a negative association of concentration with pH, and volume, WBC in all groups. No association was found with the morphology of sperm. Conclusion: It has been concluded that zinc interfered with fertility by having a considerable impact on many semen parameters. It suggests that measuring seminal plasma zinc could be useful for diagnosing and treating male infertility.

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Evaluating the Serum and Seminal Plasma Levels of Zinc and Cadmium in Smokers and Their Relation to the Semen Parameters

Cited by 9 publications

References 38 publications

Correlation of the zinc level in the spermoplasm with the fertility characteristics of human ejaculate

Correlation of the zinc level in the spermoplasm with the fertility characteristics of human ejaculate

Diet Quality Scores and Asthenoteratozoospermia Risk: Finding From a Hospital-Based Case–Control Study in China

Association of Zinc Concentration in Seminal Plasma and Blood with Several Parameters of Semen in Infertile Males

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