Evaluating the role of high-sensitivity C-reactive protein in asthmatic Iraqi patients and its correlation with parameters of patients’ clinical characteristics and pulmonary function tests

Najdat, Muhammed Saleh; Lutfi, Ahmed M

doi:10.3126/ajms.v7i3.13880

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…15 Severity of asthma associates positively with the asthmatic aggravation. 16 Significant differentiations in hs-CRP levels between subjects with serious asthma and controls without respiratory manifestations have as of late appeared in one examination. 17 Interestingly, Takemura et al, hs-CRP levels were simply disposed in steroid-innocent patients diverged from controls.…”

Section: Discussionmentioning

confidence: 99%

A high-sensitivity C-reactive protein in assessing severity of asthma: A case control study

Krishna¹,

Rao²,

Ahmed³

et al. 2021

IJIRM

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Asthma is often believed to be a disorder localized to the lungs, current evidence indicates that it may represent a component of systemic airway disease involving the entire respiratory tract. Despite significant improvements in the diagnosis and management of asthma over the past decade, as well as the availability of comprehensive and widely-accepted national and international clinical practice guidelines for the disease.This is prospective and descriptive study patients were derived among patients with asthma presented for follow -up examination in outpatient Department of pulmonary Medicine of Government Hospital. The patients were on maintenance treatment including inhaled corticosteroids and bronchodilators according to the guideline treatment of asthma. In our present study, a total of 65 patients were included out of which 36(55.3%) were males. In our study, most of the patients were 51-70 years i.e., 36 out of 65(55.4%), followed by 31-50. The mean hsCRP in case group patients are 3.62±0.84 and in control group patients 0.83±0.15. Pulmonary lung function test using Spirometer was done in all the patients (case & control). The FEV1 values are compared against hsCRP values. Statistical significance is assessed using Spearmann’s correlation. Case group patients showing highly significant negative correlation of hsCRP with FEV1.The results of this study indicate increased serum hsCRP concentration in asthma compared to controls. Increased serum hs-CRP correlates positively with severity of asthma and thus can be considered as a tool in predicting asthma status.

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Section: Discussionmentioning

confidence: 99%

A high-sensitivity C-reactive protein in assessing severity of asthma: A case control study

Krishna¹,

Rao²,

Ahmed³

et al. 2021

IJIRM

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“…The test gives results in 25 minutes with sensitivity down to 0.04 mg/L. The American Heart Association and U.S. Centers for Disease Control and Prevention have defined risk groups as low risk (less than 1.0 mg/L), average risk (1.0 to 3.0 mg/L), and high risk (above 3.0 mg/L was taken into account 10 .…”

Section: Estimation Of High-sensitivity C-reactive Proteinmentioning

confidence: 99%

Role of hsCRP as a marker in assessing severity of asthma

Balaji¹,

Mathanraj²,

Praveenraj³

2020

IJIRM

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Asthma is usually characterized by chronic airway inflammation along with respiratory manifestations like, shortness of breath, wheezing, chest tightness and variable expiratory airflow limitation. Studies have indicated increased levels of systemic markers high sensitivity C-reactive protein in patients with bronchial asthma. Assessment of the levels of high sensitivity C-reactive protein in asthmatic patients.It is a comparative-descriptive and observational study, done during the study period April 2014 – June 2015, and the number of asthmatic patients was 80 and 24 healthy controls. High sensitivity C-reactive protein (hsCRP) levels increased in asthmatic patients irrespective of the use of Inhaled corticosteroids. The mean high sensitivity C-reactive protein level of group A (steroid naïve) is 3.9085 which is higher than that of group B (steroid using patients) 2.7575 and healthy controls 0.5138. Although using Inhaled corticosteroids lead to decrease in hsCRP levels, the difference between the means of hsCRP among the two groups A and B was not statistically significant (p=0.093). But when hsCRP levels of group A and group B are compared with the controls, there was high statistical significance (p=0.001). In Pulmonary function test results, the relationship between hsCRP and FEV1 (forced expiratory volume) showed a negative correlation of hs CRP with FEV1%, and it had even more significant negative correlation in patients who are steroid naïve than patients using steroids. Diminished pulmonary function is related with raise serum hsCRP level more in steroid naive patients. Serum hsCRP can be used as one of the indirect parameters for the assessment of degree of severity in the airways manifestation.

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Evaluating the role of high-sensitivity C-reactive protein in asthmatic Iraqi patients and its correlation with parameters of patients’ clinical characteristics and pulmonary function tests

Cited by 2 publications

References 17 publications

A high-sensitivity C-reactive protein in assessing severity of asthma: A case control study

A high-sensitivity C-reactive protein in assessing severity of asthma: A case control study

Role of hsCRP as a marker in assessing severity of asthma

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