Evaluating the Relationship of Airflow Obstruction in COPD with Severity of OSA Among Patients with Overlap Syndrome

Stewart, Nancy H.; Brittan, Mollie; McElligott, Maureen; Summers, Michael O.; Samson, Kaeli; Press, Valerie G.

doi:10.2147/copd.s355897

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…In contrast, as expected, the comparison of the OS group to OSA-only patients showed significantly lower values of FEV 1 /FVC, FEV 1 , FVC%, peak expiratory flow, and SaO 2 in the first group [55,56,62]. However, the severity of COPD did not have an impact on the severity of OSA in patients with an OS diagnosis [27,38,84]. On the other hand, unrecognized and untreated OSA increased hospital readmissions in patients admitted for COPD exacerbation [24,34,[85][86][87], but treatment with continuous positive airway pressure (CPAP) in OS patients decreased the risk of COPD exacerbation to frequencies similar to those in COPD-only groups [14].…”

Section: Polysomnography Findings and Pulmonary Function In Overlap S...mentioning

confidence: 79%

The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review

et al. 2022

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Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) are common diseases that strongly impact the quality and length of life. Their coexistence is determined by overlap syndrome (OS). This systematic review aims to define the significance of these comorbidities according to the current state of knowledge. For this systematic review, we searched PubMed, Scopus, and Cochrane for studies published between 2018 and 26 October 2022, to find original, observational, human studies published in English, where the diagnosis of COPD was according to the Global Initiative for Obstructive Lung Disease guidelines and the diagnosis of OSA was based on polysomnography. The quality of studies was assessed using the Newcastle–Ottawa quality assessment tool for cohort and case–control studies, as well as its modification for cross-sectional studies. Of the 1548 records identified, 38 were eligible and included in this systematic review. The included studies covered a total population of 27,064 participants. This paper summarizes the most important, up-to-date information regarding OS, including the prevalence, meaning of age/gender/body mass index, polysomnography findings, pulmonary function, comorbidities, predicting OSA among COPD patients, and treatment of this syndrome.

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Section: Polysomnography Findings and Pulmonary Function In Overlap S...mentioning

confidence: 79%

The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review

et al. 2022

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“…However, a more recent study found a lack of relationship between the severity of airway obstruction and the severity of OSA [41].…”

Section: Discussionmentioning

confidence: 92%

Predictors of obstructive sleep apnea in patients with chronic obstructive pulmonary disease

Kaddah,

Soliman,

Mousa

et al. 2023

Egypt J Bronchol

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Background The co-existence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is known as overlap syndrome, and both conditions share common risk factors and are associated with co-morbidities and poor outcomes. Methodology Sixty stable COPD patients were included in the study. We assessed body measurements, pulmonary functions to diagnose and assess COPD severity, arterial blood gases, STOB-BANG questionnaire (SBQ), Epworth sleepiness scale (ESS), and polysomnography (PSG) for diagnosis and classification of OSA severity. The aim of the study is to assess predictors of OSA among COPD patients. Results The prevalence of overlap syndrome was 70% among studied stable COPD patients, with a male-to-female ratio of 2:1, and SBQ and ESS were statistically higher in overlap syndrome with p values < 0.001 and 0.002, respectively. Oxygen desaturation index (ODI) was 42.72 ± 30.02 for overlap in comparison to 13.18 ± 5.80 for COPD with a significant p value of < 0.001, and T90 was significantly increased in the overlap group (26.75 ± 10.37) than the COPD-only group (1.8 ± 0.98, p value ≤ 0.001). We found a direct correlation between the GOLD stage and severity of OSA in overlap syndrome. The best cutoff value for the detection of overlap syndrome was ESS = 9 (sensitivity = 88.6% and specificity = 62.5%) and SBQ = 5 (sensitivity = 63.6% and specificity = 93.8%). Conclusion Overlap syndrome represents 70% of stable COPD patients. A direct relation was found between the GOLD stage and OSA severity in overlap syndrome. ESS and SBQ can be used for screening for OSA in COPD patients but with a lower cutoff value than those used for the general population. Trial registration Retrospectively registered, registration number is NCT05605431, date of registration October 29, 2022.

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“…OSA and COPD are among the most prevalent chronic diseases and represent a major economic burden for healthcare systems worldwide (6). The clinical presentation of OSA-COPD 'overlap syndrome' compared to OSA alone remains undefined and more research is needed to elucidate how the association of both diseases exercises an impact on cardiovascular (CV) health (7). The objective of this paper was to study the main differences between OSA in patients with OSA alone, compared to OSA and COPD and to OSA, COPD and obesity.…”

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confidence: 99%

Sleep apnoea syndrome in patients with chronic obstructive pulmonary disease and obesity – hypoxic load, comorbidities

Stupar,

Virginia-Mihaela,

Popa

et al. 2022

Pneumologia

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Introduction We analyse anthropometric, somnopolygraphic and comorbidities data in patients with OSA syndrome, OSA with COPD, and OSA with COPD and obesity. Material and method 2644 OSA patients, three groups: I – OSA (2112 pts., 79.9%); II – OSA and COPD (116 pts., 4.4%); III – OSA, COPD and obesity (416 pts., 15.7%). Results significantly older (p < 0.01, p = 001, p < 0.01); more men: 68.4% vs. 80.2% vs. 78.8%; smokers 59.4% vs. 70.7% vs. 74.3%; larger neck circumference: 42.74 ± 5.08 cm vs. 40.57 ± 3.97 cm vs. 45.90 ± 4.92 cm; higher BMI; lower O2 saturation: p < 0.01, p= 123, P < 0.01; higher desaturation index: 30.65 ± 26.96 vs. 18.94 ± 20.28 vs. 42.28 ± 29.02; lowest O2 saturation: (p < 0.01 0, p = 024, p< 0.01); higher AHI: p= 0.001, p < 0.01, p < 0.01; coronary artery disease: p < 0.01, p = 195, p < 0.01; heart failure: p < 0.01, p = 760, p < 0.01; arrhythmias: p < 0.01, p = 796, P < 0.01; stroke: unsignificant; diabetes mellitus: p = 0.252, p = 0.007, p = 0.794; systemic hypertension: p < 0.01, p = 0.786, p < 0.01. Conclusion COPD in OSA is more severe, with more diabetes and longer hypertension duration, but not significantly different for O2 saturation, CAD, heart failure, arrhythmia, stroke and systemic hypertension. Obesity adds to overlap OSA–COPD significant burden for all recorded data, with the exception of stroke and diabetes.

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Evaluating the Relationship of Airflow Obstruction in COPD with Severity of OSA Among Patients with Overlap Syndrome

Cited by 3 publications

References 23 publications

The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review

The Overlap Syndrome of Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease: A Systematic Review

Predictors of obstructive sleep apnea in patients with chronic obstructive pulmonary disease

Sleep apnoea syndrome in patients with chronic obstructive pulmonary disease and obesity – hypoxic load, comorbidities

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