Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination

Li, Raymond; Yeung, William Shu Biu; Lau, Esther Yuet Ying; Ho, Pak Chung; Ng, Ernest Hung Yu

doi:10.1016/j.fertnstert.2009.12.059

Cited by 48 publications

(24 citation statements)

References 26 publications

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“…1). Nos résultats sont différents de ceux publiés par l'équipe de Li et al [32] qui rapportent une modeste valeur prédictive de l'AMH sur la survenue de la grossesse. Toutefois, les critères d'exclusion ne tenaient pas compte de facteurs pouvant avoir un impact sur les taux de grossesse avec en particulier le NSMI, et les AMH dans cette population étaient globalement élevées avec des moyennes à 3,8 (2,21-6,78) et 2,17 (1,09-3,80) dans les deux groupes.…”

Section: Discussionunclassified

Valeur prédictive de l’hormone antimüllérienne sur les issues des inséminations intra-utérines

Lamazou

Fuchs

Genro

et al. 2012

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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Section: Discussionunclassified

Valeur prédictive de l’hormone antimüllérienne sur les issues des inséminations intra-utérines

Lamazou

Fuchs

Genro

et al. 2012

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

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“…Potential differences in specificity are clinically important: For example, AMH appears more specific than FSH in predicting oocyte yields [33-35] and pregnancy chances [33-37]. This should not surprise since smaller pre-antral and antral follicles, which strongly associate with serum AMH concentrations, represent a majority of GFs.…”

Section: Introductionmentioning

confidence: 99%

Defining ovarian reserve to better understand ovarian aging

Gleicher

Weghofer

Barad

2011

Reprod Biol Endocrinol

163

130

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Though a widely utilized term and clinical concept, ovarian reserve (OR) has been only inadequately defined. Based on Medline and PubMed searches we here define OR in its various components, review genetic control of OR, with special emphasis on the FMR1 gene, and discuss whether diminished OR (DOR) is treatable. What is generally referred to as OR reflects only a small portion of total OR (TOR), a pool of growing (recruited) follicles (GFs) at different stages of maturation. Functional OR (FOR) depends on size of the follicle pool at menarche and the follicle recruitment rate. Both vary between individuals and, at least partially, are under genetic control. The FMR1 gene plays a role in defining FOR at all ages. Infertility treatments have in the past almost exclusively only centered on the last two weeks of folliculogenesis, the gonadotropin-sensitive phase. Expansions of treatments into earlier stages of maturation will offer opportunity to significantly improve ovarian stimulation protocols, especially in women with DOR. Dehydroepiandrosterone (DHEA) may represent a first such intervention. Data generated in DHEA-supplemented women, indeed, suggest a new ovarian aging concept, based on aging of ovarian environments and not, as currently is believed, aging oocytes.

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“…Moreover, high AMH levels (> 45 pmol/L) are indicative of polycystic ovary (PCO) and these patients are usually susceptible to ovarian hyperstimulation syndrome (OHSS) following hormonal induction. The serum AMH concentrations, being independent of the phase of the reproductive cycle, also appear to have some predictive value with respect to the pregnancy outcome [9,10]. …”

Section: Introductionmentioning

confidence: 99%

Circulating LH/hCG receptor (LHCGR) may identify pre-treatment IVF patients at risk of OHSS and poor implantation

Chambers

Nayini

Mills

et al. 2011

Reprod Biol Endocrinol

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BackgroundSuccessful pregnancy via in vitro fertilization (IVF) depends on the recovery of an adequate number of healthy oocytes and on blastocyst implantation following uterine transfer. Two hormones, LH and hCG, utilize a common LH/hCG receptor (LHCGR), variations in which have profound implications in human reproduction. Soluble LHCGR (sLHCGR) is released from experimental cell lines and placental explants and it can be detected in the follicular fluid and serum.MethodsTo evaluate the impact of circulating soluble LHCGR (sLHCGR) in fertility treatment, we measured sLHCGR and LH-sLHCGR complex in serum from women seeking IVF using specifically developed quantitative enzyme-linked immunosorbent assays (ELISA). Following an IVF cycle of treatment, patients were grouped according to oocyte yield into low (lower than or equal to 7 oocytes), intermediate (8-14 oocytes) and high (greater than or equal to 15 oocytes) responders and pregnancy outcome noted.ResultsPre-treatment sLHCGR identified many women at risk of ovarian hyperstimulation. Low levels of sLHCGR were associated with pregnancy in both high and low responders but sLHCGR did not significantly affect the treatment outcome of intermediate responders. Low responders who failed to become pregnant had high levels of circulating sLHCGR bound to LH (LH-sLHCGR).ConclusionsPre-treatment measurement of sLHCGR could be used to tailor individual fertility treatment programs and improve outcomes by avoiding ovarian hyperstimulation and poor embryo implantation.

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Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination

Cited by 48 publications

References 26 publications

Valeur prédictive de l’hormone antimüllérienne sur les issues des inséminations intra-utérines

Valeur prédictive de l’hormone antimüllérienne sur les issues des inséminations intra-utérines

Defining ovarian reserve to better understand ovarian aging

Circulating LH/hCG receptor (LHCGR) may identify pre-treatment IVF patients at risk of OHSS and poor implantation

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