Evaluating the outcomes of Sudanese septic patients who necessitated invasive mechanical ventilation

Abstract

Background: Sepsis is a complicated disorder highlighted by the concurrent acceleration of coagulation and inflammation as a consequence of microbial assault. It has an important influence on hospitalized patients' need for mechanical ventilation and ICU admission. Objectives: The study's primary goal is to determine whether septic patients who require invasive mechanical ventilation fared well and whether their clinical condition improved or worsened after being connected to mechanical ventilation. The research also attempts to evaluate how additional medical interventions and other comorbidities affect the patient's prognosis. Material and methods: From November 2017 to May 2018, 160 patients with severe sepsis or septic shock were taken part in a prospective cross-sectional trial. The information was gathered using a straightforward, standardized questionnaire that included questions regarding the admission, progress, and outcome of septic patients who received mechanical ventilation in an intensive care unit. Results: 58 (36%) of the 160 patients were female, with 102 (64%) of the patients being male. In the age range of 60 to 70 years, 41 of them (or 25.6%) were detected. The majority of patients (59/369) had sepsis from a chest infection. Most of the patients, 87 (54.4%), got a combination of midazolam and fentanyl for sedation and analgesia. The majority of the patients, 85 (53%) had SIM/PS ventilation. Ultimately, 71 patients (44.4%) died, 80 patients (50%) were extubated, and 9 patients (5.6%) remained stationary and had a tracheostomy. Additionally, age, reasons, sedative type, and duration of stay were all substantially linked with the MV consequences (P 0.05). Conclusion: The better the outcome, the earlier septic patients who need IMV were identified and attached to IMV. It has been demonstrated that receiving IMV decreased mortality in septic patients by around 50%. The findings suggest that this intervention should be made more widely available and more reasonably priced by the authorities, along with the training of additional staff and the development of standard protocols for treating patients with such a condition. Focusing on health education awareness, establishing a focused outpatient department, and promptly screening patients who necessitate early referral to a tertiary care facility are the three most crucial aspects.