Evaluating the male and female reproductive toxicity of high-boiling petroleum substances

Murray, F. Jay; Gray, Thomas M.; Roberts, Linda G.; Roth, Randy N.; Nicolich, Mark J.; Simpson, Bob

doi:10.1016/j.yrtph.2013.04.004

Cited by 18 publications

(10 citation statements)

References 41 publications

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“…3,4 Several recent studies have shown that analytical–chemical properties, specifically the aromatic ring class (ARC) profiles of certain high-boiling petroleum substances, correlate well with reproductive and developmental toxicity and mutagenicity of petroleum substances. 5–7 However, category read-across approaches for UVCBs that are based solely on such broad similarity parameters may not always be considered sufficient. Adding a biological data-based read-across component, 8 i.e.…”

Section: Introductionmentioning

confidence: 99%

A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

Grimm

Iwata

Sirenko³

et al. 2016

Green Chem.

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Section: Introductionmentioning

confidence: 99%

A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

Grimm

Iwata

Sirenko³

et al. 2016

Green Chem.

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“…Sexually mature secretory glands were distributed throughout the mucosal folds lined by columnar pseudo-stratified epithelium and had both ciliated and non-ciliated cells [ 33 ]. The effect of 4-NP on the oviduct of chickens prior to the hatching period was shown in Figure 1C .…”

Section: Resultsmentioning

confidence: 99%

“…Assessing reproductive toxicity in female animals is challenging, given the complexity of the endocrine system and despite the increasing development of data on its mechanism [ 30 , 31 , 32 , 33 ]. To study the bioaccumulation of surfactants and to explore both effects and underlying mechanisms of hormonal balance disruption and developmental abnormalities of ovary and oviduct caused by NP, we utilized 4-NP as test substance, employing female chickens (Hy-Line Variety White) as experimental model.…”

Section: Introductionmentioning

confidence: 99%

Adverse stimulation of 4-nonylphenol in abnormal reproductive organs of female chickens

et al. 2017

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4-Nonylphenol (4-NP) is a known endocrine disrupting chemical and a persistent environmental contaminant. However, the 4-NP caused mechanism of reproductive toxicity still remains largely unknown in birds. In this study, female chickens (Hy-Line Variety White) were dosed via oral gavage in the early laying period with 0, 50, 100, and 200 mg 4-NP/kg/d for 60 days. Food intake and weight increase were monitored in this organism to investigate chicken growth and development. Moreover, pathological changes of reproductive organs, serum hormone, and mRNA changes on the HPOA were detected. The results showed that gonad development and maturity were retarded in female chickens, and the circulating concentrations of sex hormones were disordered in 4-NP-treated chicken. In 4-NP exposed animals, the mRNA expressions of GnRH and PRLH in hypothalamus and FSH and LH in pituitary were significantly unregulated by 4-NP. In addition, expressions of FSHR and LHR were down-regulated in ovaries of the 4-NP-treatment group, while the levels of stAR, P450scc, P450arom, 3β-HSD, and 17β-HSD were up-regulated in ovaries. Furthermore, expression of ERα in the ovaries of chicken was up-regulated, however, no significant change was observed for ERβ expression. Our results suggest that granulosa cells were an important target and severely disturbed by 4-NP.

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“…In a recent study, high-boiling petroleum substances, including many with a high PAC content, have demonstrated low potential to cause male or female reproductive toxicity relative to developmental toxicity and systemic toxicity (in repeat-dose toxicity studies). 56…”

Section: Discussionmentioning

confidence: 99%

Acute, Subchronic, and Developmental Toxicological Properties of Lubricating Oil Base Stocks

Dalbey¹,

McKee

Goyak

et al. 2014

Int J Toxicol

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Lubricating oil base stocks (LOBs) are substances used in the manufacture of finished lubricants and greases. They are produced from residue remaining after atmospheric distillation of crude oil that is subsequently fractionated by vacuum distillation and additional refining steps. Initial LOB streams that have been produced by vacuum distillation but not further refined may contain polycyclic aromatic compounds (PACs) and may present carcinogenic hazards. In modern refineries, LOBs are further refined by multistep processes including solvent extraction and/or hydrogen treatment to reduce the levels of PACs and other undesirable constituents. Thus, mildly (insufficiently) refined LOBs are potentially more hazardous than more severely (sufficiently) refined LOBs. This article discusses the evaluation of LOBs using statistical models based on content of PACs; these models indicate that insufficiently refined LOBs (potentially carcinogenic LOBs) can also produce systemic and developmental effects with repeated dermal exposure. Experimental data were also obtained in ten 13-week dermal studies in rats, eight 4-week dermal studies in rabbits, and seven dermal developmental toxicity studies with sufficiently refined LOBs (noncarcinogenic and commonly marketed) in which no observed adverse effect levels for systemic toxicity and developmental toxicity were 1000 to 2000 mg/kg/d with dermal exposures, typically the highest dose tested. Results in both oral and inhalation developmental toxicity studies were similar. This absence of toxicologically relevant findings was consistent with lower PAC content of sufficiently refined LOBs. Based on data on reproductive organs with repeated dosing and parameters in developmental toxicity studies, sufficiently refined LOBs are likely to have little, if any, effect on reproductive parameters.

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Evaluating the male and female reproductive toxicity of high-boiling petroleum substances

Cited by 18 publications

References 41 publications

A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

A chemical–biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives

Adverse stimulation of 4-nonylphenol in abnormal reproductive organs of female chickens

Acute, Subchronic, and Developmental Toxicological Properties of Lubricating Oil Base Stocks

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