Evaluating the longitudinal effect of colorectal surgery on health‐related quality of life in patients with colorectal cancer

Abstract

Background and Objectives: Surgery for colorectal cancer (CRC) negatively affects health-related quality of life (HRQoL). Addressing shortcomings in literature, the purpose of this study was to evaluate the impact of surgery for CRC on the course of HRQoL from baseline up to 2 years after diagnosis.Methods: In this prospective, population-based study patients with newly diagnosed CRC were included between 2016 and 2019. HRQoL was assessed by the EORTC QLQ-C30 questionnaire over time both between and within subgroups of patients that underwent right-sided colonic, left-sided colonic, and rectal resection using linear mixed model analyses. Results:The study included 415 patients of whom 148 patients underwent right-sided colonic (36%), 147 left-sided colonic (35%), and 120 rectal resection (29%). Overall, HRQoL scores restored to baseline level 1 year after diagnosis.Impact of surgery seems to be more prominent in patients who underwent rectal resection, as they experienced more pain and had worse role and social functioning scores 4 weeks after surgery. Finally, among patients who underwent left-sided and rectal resection, physical functioning did not return to baseline level during follow-up. Conclusion:This study shows several differences (between-group and within-group) in HRQoL according to surgery type and offers perspective which patients may need additional support in the care pathway.

Quality of Life of Colorectal Cancer patients and its association with Anxiety and Depression: Cross sectional study at a tertiary care hospital in low-middle income country

“…Among functional scales of C30, only physical functioning (78.72) was found to be lower than TCI in our CRC patients and we found this similar to another study reported on all GI cancer in Pakistan (22). Physical functioning scores have been reported in a diverse range (62.9-90) in the published literature (14,16,18,27). This high variability is likely due to the variable stage of disease and the location of tumor as treatment modalities and stoma have signi cant effect on physical functioning of CRC patients.…”

Evaluating the longitudinal effect of colorectal surgery on health‐related quality of life in patients with colorectal cancer

“…However, in the Discussion, the authors did not analyze whether the stoma affects the HRQoL scores of rectal resection. 1 In our clinical work, we found that stoma can significantly reduce the quality of life of rectal resection, which is mainly due to the following reasons.…”

“…We have read with interest the article published by Reudink et al 1 At present, more and more attention has been paid to the quality of life of patients after colorectal resection. 2 Although we believe it is a very interesting topic, we would like to offer the following points for your consideration.…”

The association between anastomotic leakage and health‐related quality of life after colorectal cancer surgery

“…recovers in the majority of patients to baseline values within the first year after surgery [6][7][8]. Compared to the general population, HRQoL scores were only slightly attenuated in CRC patients 1 year after diagnosis [9].…”

“…Studies evaluating HRQoL among CRC patients demonstrated that HRQoL substantially declines in the early postoperative period and recovers in the majority of patients to baseline values within the first year after surgery [6‐8]. Compared to the general population, HRQoL scores were only slightly attenuated in CRC patients 1 year after diagnosis [9].…”