Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity

Katrinli, Şeyma; Stevens, Jennifer S.; Wani, Agaz H.; Lori, Adriana; Kilaru, Varun; Rooij, Sanne J.H. van; Hinrichs, Rebecca; Powers, Abigail; Gillespie, Charles F.; Michopoulos, Vasiliki; Gautam, Aarti; Jett, Marti; Hammamieh, Rasha; Yang, Ruoting; Wildman, Derek E.; Qu, Annie; Koenen, Karestan C.; Aiello, Allison E.; Uddin, Monica; Ressler, Kerry J.; Smith, Alicia K.

doi:10.1038/s41386-020-0700-5

Cited by 73 publications

(86 citation statements)

References 63 publications

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“…Third, homelessness might be the breaking point for those who have pre-existing behavioral health conditions or a prior history of trauma [ 22 ]. Homeless migrants’ families cumulate risk factors for developing PTSD that could impact physical [ 23 ] and other mental disorders (depression, anxiety disorders) [ 24 , 25 ] and also impact biological (cellular aging [ 26 ]) and social functioning [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Post-Traumatic Stress Disorder in Homeless Migrant Mothers of the Paris Region Shelters

Roze

Melchior

Vuillermoz

et al. 2020

IJERPH

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Migrant women are disproportionately more likely to experience traumatic events in their country of origin, during migration and after arriving in the host country. Homeless women are more likely to be exposed to multiple victimizations in childhood (emotional or physical maltreatment) and in adulthood (sexual abuse, street victimization). This study’s objective was to describe the factors associated with the likelihood of post-traumatic stress disorder (PTSD) among homeless migrant mothers in the Paris region. Face-to-face interviews were conducted by bilingual psychologists and interviewers in a representative sample of homeless families in the Paris region. PTSD was ascertained using the Mini International Neuropsychiatric Interview (MINI) (n = 691 mothers). We studied PTSD in mothers using weighted Poisson regression. Homeless migrant mothers had high levels of PTSD (18.9%) in the 12 months preceding the study. In multivariate analysis, PTSD was associated with departure from the country of origin because of violence (PR = 1.45 95% CI 1.03; 2.04), depression in the preceding 12 months (PR = 1.82 95% CI 1.20; 2.76), and residential instability (PR = 1.93 95% CI 1.27; 2.93). Homeless migrant mothers have high levels of traumatic events and PTSD. Improvements in screening for depression and PTSD and access to appropriate medical care are essential for this vulnerable group.

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Section: Introductionmentioning

confidence: 99%

Post-Traumatic Stress Disorder in Homeless Migrant Mothers of the Paris Region Shelters

Roze

Melchior

Vuillermoz

et al. 2020

IJERPH

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“…On the other hand, one of the main symptoms of PTSD is an elevated rumination characterised by repetitive, negative self-focused cognition, and it has been reported that a reduced functional connectivity between the isthmus cingulate and the left precuneus within the DMN is linked to this high level of rumination [22]. Lifetime trauma burden and suffering from both current and lifetime PTSD have been reported to cause GrimAge acceleration [23]. It has also been found that patients with Alzheimer's disease (AD) and in the prodromal stage of AD have decreased DMN functions and precuneus GM volume compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Epigenetic Clock Deceleration and Maternal Parity: Associations With Increasing Grey Matter Volume of the Precuneus

Nishitani¹,

Kasaba²,

Hiraoka³

et al. 2020

Preprint

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Reproductive effort experiences, such as pregnancy, delivery, and interaction with their children, make female maternal brains optimised for child-rearing. However, extensive studies in non-human species revealed there is a trade-off between reproductive effort and life expectancy. In humans, large demographic studies have shown that this is the case for the most part, but molecular marker studies of aging remain controversial, and there are no studies evaluating the relationship between reproductive effort, aging, and brain structures simultaneously. We examined the associations among the reproductive efforts, DNA methylation age acceleration, and the regional grey matter of structural brain scans by voxel-based morphometry in 27-46-year-old mothers. We found that greater reproductive efforts, including the number of delivery and motherhood periods, were significantly associated with decelerated aging in mothers with 1-4 children. We also found that the precuneus grey matter volume was larger as age deceleration occurred and found a mediation effect of the greater left precuneus grey matter volume on the relationship between parity and age deceleration. Our findings suggest that mothers of early childhood children who have less than four children may benefit from aging via precuneus structural changes.

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“…Acting through oxidative stress and inflammation pathways, PTSD and traumatic experiences are thought to advance cellular aging and reduce life span. 273 These adverse experiences triggering psychological stress result in accelerated biological aging and alteration in DNA methylation patterns, which are recorded on a person's epigenetic clock. GrimAge, an epigenetic predictor of lifespan, combines methylation levels at specific CpG sites that predict biological age combined with additional biomarkers (sex, smoking pack-years, and others).…”

Section: Stress and Epigeneticsmentioning

confidence: 99%

“…Chronic inflammation as found in PTSD appears to be involved in the relationship between PTSD and GrimAge acceleration. 273 Low-grade inflammation, as measured by serum C-reactive protein, and immunosenescence contribute to aging. This low-grade inflammation, referred to as inflammaging, is an imbalance between pro-and antiinflammatory pathways and is common in the elderly.…”

Section: Stress and Epigeneticsmentioning

confidence: 99%

SARS‐CoV‐2 multifaceted interaction with the human host. Part II: Innate immunity response, immunopathology, and epigenetics

Beacon

Su²,

Lakowski

et al. 2020

IUBMB Life

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The SARS-CoV-2 makes its way into the cell via the ACE2 receptor and the proteolytic action of TMPRSS2. In response to the SARS-CoV-2 infection, the innate immune response is the first line of defense, triggering multiple signaling pathways to produce interferons, pro-inflammatory cytokines and chemokines, and initiating the adaptive immune response against the virus. Unsurprisingly, the virus has developed strategies to evade detection, which can result in delayed, excessive activation of the innate immune system. The response elicited by the host depends on multiple factors, including health status, age, and sex. An overactive innate immune response can lead to a cytokine storm, inflammation, and vascular disruption, leading to the vast array of symptoms exhibited by COVID-19 patients. What is known about the expression and epigenetic regulation of the ACE2 gene and the various players in the host response are explored in this review.

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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity

Cited by 73 publications

References 63 publications

Post-Traumatic Stress Disorder in Homeless Migrant Mothers of the Paris Region Shelters

Post-Traumatic Stress Disorder in Homeless Migrant Mothers of the Paris Region Shelters

Epigenetic Clock Deceleration and Maternal Parity: Associations With Increasing Grey Matter Volume of the Precuneus

SARS‐CoV‐2 multifaceted interaction with the human host. Part II: Innate immunity response, immunopathology, and epigenetics

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