Evaluating the impact of repeated community‐wide health surveys on cardiovascular morbidity and mortality in the Busselton population

Knuiman, Matthew; Clarkson, Jo; Bulsara, Max; Bartholomew, Helen C.

doi:10.1111/j.1467-842x.2004.tb00706.x

Cited by 10 publications

(4 citation statements)

References 28 publications

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“…It might be anticipated that the prevalence of other smoking‐related diseases in the Busselton population also declined over the 50‐year period of the surveys. Consistent with the results of our study, it has indeed been reported that heart disease mortality in Busselton has improved 14 …”

Section: Discussionsupporting

confidence: 93%

Obstructive airway disease in 46–65‐year‐old people in Busselton, Western Australia, 1966–2015

Musk¹,

Hunter

Hui

et al. 2018

Medical Journal of Australia

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Objective: To document the changing levels of tobacco smoking, respiratory symptoms, doctor‐diagnosed asthma, and lung function in Busselton adults aged 46–65 years over the past 50 years. Design, setting, participants: Repeated cross‐sectional population surveys (1966 to 2010–2015) of adults registered to vote in the Busselton shire, Western Australia, including a modified version of the British Medical Research Council questionnaire on respiratory symptoms. Main outcome measures: History of doctor‐diagnosed asthma and chronic obstructive pulmonary disease (COPD), tobacco smoking history, respiratory medications used, spirometry parameters (forced expiratory volume in one second [FEV1], forced vital capacity [FVC]). Results: The prevalence of tobacco smoking among men declined from 53% in 1966 to 12% in 2010–2015, and from 26% to 9% among women. The prevalence of ever‐smoking (ie, smokers and ex‐smokers) decreased from 80% to 57% for men but increased from 33% to 50% for women. The prevalence of doctor‐diagnosed asthma increased, as did the use of long‐acting bronchodilator aerosol medications by people with asthma and COPD. There have been no consistent changes in the prevalence of specific respiratory symptoms, but measures of lung function have significantly improved. Conclusions: Smoking rates declined as a result of changes in pricing, prohibitions on smoking and the feedback of survey results to Busselton participants. Significant improvements in lung function were measured, and it can be anticipated that the prevalence of other smoking‐related diseases will also decline.

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Section: Discussionsupporting

confidence: 93%

Obstructive airway disease in 46–65‐year‐old people in Busselton, Western Australia, 1966–2015

Musk¹,

Hunter

Hui

et al. 2018

Medical Journal of Australia

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“…These factors may also affect generalizability, particularly with disease incidence and prevalence. An earlier analysis of the impact of the surveys on mortality and hospital morbidity found no conclusive impact of the surveys [63]. …”

Section: Discussionmentioning

confidence: 99%

Rationale, design and methods for a community-based study of clustering and cumulative effects of chronic disease processes and their effects on ageing: the Busselton healthy ageing study

et al. 2013

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BackgroundThe global trend of increased life expectancy and increased prevalence of chronic and degenerative diseases will impact on health systems. To identify effective intervention and prevention strategies, greater understanding of the risk factors for and cumulative effects of chronic disease processes and their effects on function and quality of life is needed.The Busselton Healthy Ageing Study aims to enhance understanding of ageing by relating the clustering and interactions of common chronic conditions in adults to function. Longitudinal (3–5 yearly) follow-up is planned.Methods/designPhase I (recruitment) is a cross-sectional community-based prospective cohort study involving up to 4,000 'Baby Boomers’ (born from 1946 to 1964) living in the Busselton Shire, Western Australia. The study protocol involves a detailed, self-administered health and risk factor questionnaire and a range of physical assessments including body composition and bone density measurements, cardiovascular profiling (blood pressure, ECG and brachial pulse wave velocity), retinal photography, tonometry, auto-refraction, spirometry and bronchodilator responsiveness, skin allergy prick tests, sleep apnoea screening, tympanometry and audiometry, grip strength, mobility, balance and leg extensor strength. Cognitive function and reserve, semantic memory, and pre-morbid intelligence are assessed. Participants provide a fasting blood sample for assessment of lipids, blood glucose, C-reactive protein and renal and liver function, and RNA, DNA and serum are stored. Clinically relevant results are provided to all participants. The prevalence of risk factors, symptoms and diagnosed illness will be calculated and the burden of illness will be estimated based on the observed relationships and clustering of symptoms and illness within individuals. Risk factors for combinations of illness will be compared with those for single illnesses and the relation of combinations of illness and symptoms to cognitive and physical function will be estimated.DiscussionThis study will enable a thorough characterization of multiple disease processes and their risk factors within a community-based sample of individuals to determine their singular, interactive and cumulative effects on ageing. The project will provide novel cross-sectional data and establish a cohort that will be used for longitudinal analyses of the genetic, lifestyle and environmental factors that determine whether an individual ages well or with impairment.

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“…Twenty elderly men with a wide range of serum ferritin levels were recruited from an ongoing community‐based study, the Busselton Health Survey (16). Only males were studied, in the expectation that their peripheral iron levels would in general be higher compared to females (3).…”

Section: Methodsmentioning

confidence: 99%

Relationship between brain R₂ and liver and serum Iron concentrations in elderly men

House

Pierre

Milward

et al. 2010

Magnetic Resonance in Med

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Studies of iron overload in humans and animals suggest that brain iron concentrations may be related in a regionally specific way to body iron status. However, few quantitative studies have investigated the associations between peripheral and regional brain iron in a normal elderly cohort. To examine these relationships, we used MRI to measure the proton transverse relaxation rate (R 2 ) in 13 gray and white matter brain regions in 18 elderly men (average age, 75.5 years) with normal cognition. Brain R 2 values were compared with liver iron concentrations measured using the FerriScan V R MRI technique and serum iron indices. R 2 values in high-iron gray matter regions were significantly correlated (positively) with liver iron concentrations (globus pallidus, ventral pallidum) and serum transferrin saturation (caudate nucleus, globus pallidus, putamen) measured concurrently with brain R 2 , and with serum iron concentrations (caudate nucleus, globus pallidus) measured three years before the current study. Our results suggest that iron levels in specific gray matter brain regions are influenced by systemic iron status in elderly men. Magn Reson Med 63:275-281,

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Evaluating the impact of repeated community‐wide health surveys on cardiovascular morbidity and mortality in the Busselton population

Cited by 10 publications

References 28 publications

Obstructive airway disease in 46–65‐year‐old people in Busselton, Western Australia, 1966–2015

Obstructive airway disease in 46–65‐year‐old people in Busselton, Western Australia, 1966–2015

Rationale, design and methods for a community-based study of clustering and cumulative effects of chronic disease processes and their effects on ageing: the Busselton healthy ageing study

Relationship between brain R₂ and liver and serum Iron concentrations in elderly men

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Evaluating the impact of repeated community‐wide health surveys on cardiovascular morbidity and mortality in the Busselton population

Cited by 10 publications

References 28 publications

Obstructive airway disease in 46–65‐year‐old people in Busselton, Western Australia, 1966–2015

Obstructive airway disease in 46–65‐year‐old people in Busselton, Western Australia, 1966–2015

Rationale, design and methods for a community-based study of clustering and cumulative effects of chronic disease processes and their effects on ageing: the Busselton healthy ageing study

Relationship between brain R2 and liver and serum Iron concentrations in elderly men

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Relationship between brain R₂ and liver and serum Iron concentrations in elderly men