Developing an awareness of cost is a fundamental feature of prescribing practice and the Royal Pharmaceutical Society (RPS) (2016) includes this principle within the 'Consultation domain' as a definitive competency for all prescribers. Within the framework, (Competency 2: Consider the options), sub-competency 2.8 states that the prescriber: 'Stays up-to-date in own area of practice and applies the principles of evidence-based practice, including clinical and cost-effectiveness'. The General Pharmaceutical Council (GPhC) (2019) stipulate that pharmacist independent prescribers should attain minimum prescribing standards against specific learning outcomes. The 'professionalism domain', learning outcome 13, within the GPhC document requires that pharmacists "apply an understanding of health economics when making prescribing decisions" (GPhC, 2019, pg. 8). Similarly, the Nursing & Midwifery Council (2018) and the Health & Care Professions Council (2019) alert their prescribing registrants to prescribe cost-effectively using the RPS competency framework.The National Prescribing Centre (NPC) (1999) devised the mnemonic EASE to alert the prescriber to consider that prescribed medications should be Effective, Appropriate, Safe and cost-Effective. In terms of cost, the use of EASE during the prescribing process prompts the prescriber to consider whether their prescribing decisions take account of budgetary constraints and health economics. Haycox (2009) defines health economics as a valuable tool for improving clinical decisions whereby the prescriber identifies alternative, cost-based options for their patients in respect of drug choice and maps this against clinical efficacy, available resources and patient outcomes.