Evaluating the<i>QuikRead®</i>C-reactive protein test as a point-of-care test

Diar, H; Nakwa, Firdose; Thomas, Reenu; Libhaber, Elena; Velaphi, Sithembiso

doi:10.1179/1465328111y.0000000045

Cited by 9 publications

(2 citation statements)

References 18 publications

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“…At least three tests, including the one used in this study, are small, portable, battery powered devices that require ≤20 microliters of whole blood and provide a numerical readout (8–160 mg/l) within 4 minutes. 31 Two semi-quantitative tests use a test cassette and reagent buffer, without a machine, and provide information on CRP being less than or greater than 10 mg/l. 32 Although we evaluated a variety of CRP levels, we used a CRP > 8 mg/l since it is commonly used in rapid tests, has been reported in prior studies, 33,34 and maximizes diagnostic sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy and clinical role of rapid C-reactive protein testing in HIV-infected individuals with presumed tuberculosis in South Africa

Drain¹,

Mayeza²,

Bartman³

et al. 2014

int j tuberc lung dis

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Objective We sought to determine the accuracy and role of rapid C-reactive protein (CRP) testing in HIV-infected tuberculosis suspects. Design We enrolled HIV-infected adults (≥18 years) with a cough for ≥2 weeks and negative sputum smears for acid-fast bacilli (AFB) in KwaZulu-Natal, South Africa. Participants were evaluated for pulmonary tuberculosis by a nurse with rapid CRP, and independently by a physician with a chest radiograph. Rapid CRP test results were compared to laboratory CRP and sputum sent for confirmation of tuberculosis. Results Among 93 participants, 55 (59%) were female, mean age was 35 years, and median CD4 count was 177/mm3. Forty-five (54%) participants were diagnosed with pulmonary tuberculosis. Diagnostic sensitivity and specificity were 95% (95% CI 74–99%) and 51% (95% CI 35–66%) for rapid CRP > 8 mg/l, 87% (95% CI 73–96%) and 53% (95% CI 38–68%) for nurse assessment, and 69% (95% CI 52–83%) and 76% (95%CI 61–87%) for physician examination. Combining a positive rapid CRP (> 8 mg/l) to nurse and physician assessments decreased post- test probability of pulmonary tuberculosis from 22% to 6% and 32% to 6%, respectively. Conclusion Rapid CRP testing helped exclude pulmonary tuberculosis, and may be a valuable test to assist nurses and physicians in tuberculosis-endemic regions.

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy and clinical role of rapid C-reactive protein testing in HIV-infected individuals with presumed tuberculosis in South Africa

Drain¹,

Mayeza²,

Bartman³

et al. 2014

int j tuberc lung dis

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“…Several rapid syphilis tests have shown high specificity in comparison to a fluorescent treponemal antibody absorption test, but have also not been evaluated for patient-centered outcomes. 62–65 Additional validation studies of POC tests in RLS include a C-reactive protein test among neonates suspected of meningitis in South Africa, 66 a glucose test to diagnose diabetes in rural India 67 and hypoglycemia in Nigerian children, 68 a tetanus immunity test in Iran, 69 a test for trypanosomiasis in Angola, 70 and a test for visceral leishmaniasis in Brazil, Kenya, Sudan, and India. 71,72 However, while a phased approach to evaluating diagnostic POC tests is appropriate, few of these studies went beyond the first step of accuracy assessment to measure the clinical impact of utilizing the POC test in the appropriate clinical setting.…”

Section: Studies Of Point-of-care Tests In Resource-limited Settingsmentioning

confidence: 99%

Diagnostic point-of-care tests in resource-limited settings

Drain

Hyle

Noubary

et al. 2014

The Lancet Infectious Diseases

565

461

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Diagnostic point-of-care (POC) testing is intended to minimize the time to obtain a test result, thereby allowing clinicians and patients to make an expeditious clinical decision. As POC tests expand into resource-limited settings (RLS), the benefits must outweigh the costs. To optimize POC testing in RLS, diagnostic POC tests need rigorous evaluations focused on relevant clinical outcomes and operational costs, which differ from evaluations of conventional diagnostic tests. Here, we reviewed published studies on POC testing in RLS, and found no clearly defined metric for the clinical utility of POC testing. Therefore, we propose a framework for evaluating POC tests, and suggest and define the term “test efficacy” to describe a diagnostic test’s capacity to support a clinical decision within its operational context. We also proposed revised criteria for an ideal diagnostic POC test in resource-limited settings. Through systematic evaluations, comparisons between centralized diagnostic testing and novel POC technologies can be more formalized, and health officials can better determine which POC technologies represent valuable additions to their clinical programs.

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Evaluation of the bedside Quikread go® CRP test in the management of febrile infants at the emergency department

Hernández-Bou

Trenchs

Vanegas

et al. 2017

Eur J Clin Microbiol Infect Dis

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Recently C-reactive protein (CRP) point-of-care tests have been developed. We aimed to validate a bedside CRP test (QuikRead go® CRP), to compare it with the laboratory CRP (ARCHITECT c8000 Abbott, Germany) test in children with fever without source (FWS), and to evaluate the optimal CRP cut-off value to identify those patients at a high risk for serious bacterial infection (SBI). The CRP bedside test was prospectively performed in capillary blood samples concurrently with the laboratory CRP testing for 283 well-appearing infants aged 1 to 24 months with FWS attending the emergency department (ED) between May 2013 and August 2015. The mean difference between the laboratory CRP and the QuikRead go CRP values was 0.71 mg/L (p = 0.444). Pearson's correlation coefficient between the CRPs was r = 0.929 (p < 0.001). SBI was diagnosed in 34 patients (12.0%). The area under the receiver operating characteristics (ROC) curve obtained was 0.87 (95%CI: 0.82-0.90) for an optimal CRP cut-off value of > 10 mg/L (sensitivity: 94.1%, specificity: 49.0%, positive predictive value: 20.1%, negative predictive value: 98.4%), as a predictor of SBI. Nearly 45% of the patients were at a low risk for SBI according to CRP value; thus, additional laboratory tests would have been hypothetically avoided. There was a very strong, positive correlation between the QuikRead go CRP test and laboratory CRP determination. The QuikRead go CRP test provides reliable results to rule out SBI. Its implementation at the ED would improve the management of infants with FWS.

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Evaluating theQuikRead®C-reactive protein test as a point-of-care test

Cited by 9 publications

References 18 publications

Diagnostic accuracy and clinical role of rapid C-reactive protein testing in HIV-infected individuals with presumed tuberculosis in South Africa

Diagnostic accuracy and clinical role of rapid C-reactive protein testing in HIV-infected individuals with presumed tuberculosis in South Africa

Diagnostic point-of-care tests in resource-limited settings

Evaluation of the bedside Quikread go® CRP test in the management of febrile infants at the emergency department

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