Evaluating the Effects of Different Molecular Weights of Polymers in Stabilizing Supersaturated Drug Solutions and Formulations Using Various Methodologies of the Model Drug: Fenofibrate

Chaudhari, Smruti P.; Dave, Rutesh H.

doi:10.1166/jpsp.2015.1066

Cited by 18 publications

(9 citation statements)

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“…Hence, DI water represents the nonsink condition, and 1% SLS represents the sink condition. As per literature, FENO dispersion dissolution in nonsink media correlates better with in vivo absorption profile 14 .…”

Section: Dissolutionmentioning

confidence: 53%

Evaluating the effect of the porous and non-porous colloidal silicon dioxide as a stabilizer on amorphous solid dispersion

Chaudhari¹,

Bhadiyadra

Dave

2020

J. Drug Delivery Ther.

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Advancement in the discovery of drugs has led to many highly lipophilic compounds with very low water solubility. Amorphous solid dispersion is one of the emerging technologies to increase the solubility of these drugs. The stability of these systems is critical since the high energy system tends to recrystallize, which negates the benefits of these systems. In this paper, we are evaluating the use of colloidal silicon dioxide as a potential stabilizer to stabilize the amorphous solid dispersions. Two types of colloidal silicon dioxide are used: porous colloidal silicon dioxide -Syloid 244 Fp and nonporous fumed silica – Aerosil 200. These silicon dioxides have a high surface area. Two methods of incorporation are used to incorporate silicon dioxide into the solid dispersion. The spray drying method is used to make amorphous solid dispersion. It was found that porous silicon dioxide is better to increase stability as well as increasing dissolution rate and % release of the drug. The addition of silicon dioxide internally to the dispersion increases the dissolution rate, and the addition of silicon dioxide externally increases the stability of the solid dispersion. Keywords: colloidal silicon dioxide, stabilizer, amorphous solid dispersion, low water solubility

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Section: Dissolutionmentioning

confidence: 53%

Evaluating the effect of the porous and non-porous colloidal silicon dioxide as a stabilizer on amorphous solid dispersion

Chaudhari¹,

Bhadiyadra

Dave

2020

J. Drug Delivery Ther.

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“…Some scienstist have studied the the absorption of drug from supersaturated solution from the nasal mucosa in vitro model. The use of precipitation inhibitors 73 will be useful for delivery of supersaturated drug solution across the membranes.…”

Section: Mucoadhesive Polymers Used In Nasal Drug Deliverymentioning

confidence: 99%

Untitled

2017

IJPSR

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Nasal drug delivery has been recognized as a promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that absorption of drugs can enhanced by using absorption enhancers or increasing the drug residence time in the nasal cavity. Mucoadhesive polymers can serve both functions. The residence time in the nasal cavity is considerably increased for microspheres compared to solutions. However, this is not the only factor to increase the absorption of large hydrophilic drugs. Microspheres also exert a direct effect on the mucosa, resulting in the opening of tight junctions between the epithelial cells. This review focuses on the background of nasal mucoadhesive drug delivery with special references to the biological and pharmaceutical considerations for nasal mucoadhesive drug administration.

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“…Intravenous administration is often related to the control of fungal infections in posterior segment (endophthalmitis) 31 , but severe renal toxicity associated with systemic effect and small intraocular penetration limits its use in higher concentrations [32][33][34] . The conjunctival administration of AmB causes severe necrosis at the site of application, thus its use is not recommended 10 .…”

Section: Incorporation Of Ambmentioning

confidence: 99%

Fundamental Aspects in the Development of Microemulsion Systems Containing Amphotericin B for Ophthalmic Use

Chirlekar

Chaudhari²

2016

J. Drug Delivery Ther.

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This is an overview of the development of microemulsion systems containing amphotericin B for ophthalmic use. The amphotericin B (AmB) is used to treat a fungal infection of eye and bioavailability of the AmB is the challenge for the research scientist. The poor bioavailability of AmB is due mainly to the corneal barrier, which eventually leads to a precorneal loss and subsequent decrease in the absorption of this drug into the intraocular tissues. Also, AmB has limited permeation across the intact corneal epithelium, which along with the toxicity associated with this molecule, epitomizes a major drawback to its clinical use. Therefore, new effective and safe drug vehicles for ocular delivery of AmB are urgently required. Recently, microemulsions (MEs) have been used in ophthalmic drug delivery system owing to their thermodynamic stability, transparent appearance, and favorable viscosity. Information and proper understanding of the physical chemistry and process of formation of AmB-containing MEs would provide reliable information on the best conditions for the use of these systems as eye drops. The aim of this research was thus to review the main studies on the use of MEs as delivery systems for AmB in topical eye treatment.

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Evaluating the Effects of Different Molecular Weights of Polymers in Stabilizing Supersaturated Drug Solutions and Formulations Using Various Methodologies of the Model Drug: Fenofibrate

Cited by 18 publications

References 0 publications

Evaluating the effect of the porous and non-porous colloidal silicon dioxide as a stabilizer on amorphous solid dispersion

Evaluating the effect of the porous and non-porous colloidal silicon dioxide as a stabilizer on amorphous solid dispersion

Untitled

Fundamental Aspects in the Development of Microemulsion Systems Containing Amphotericin B for Ophthalmic Use

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