Evaluating the Effects of an Ophthalmic Solution of Coenzyme Q10 and Vitamin E in Open-Angle Glaucoma Patients: A Study Protocol

Quaranta, Luciano; Riva, Ivano; Biagioli, Elena; Rulli, Erica; Rulli, Eliana; Poli, Davide; Legramandi, Lorenzo

doi:10.1007/s12325-019-01023-3

Cited by 28 publications

(18 citation statements)

References 27 publications

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“…In a pilot study enrolling 43 OAG patients in monotherapy with β-blockers, Parisi and collaborators (2014) reported a beneficial effect on the inner retinal function, with consequent enhancement of the visual cortical responses, in patients treated with CoQun ® drops (instilled twice daily) for 6 or 12 months [ 188 ]. Currently, a multicenter controlled clinical trial on 612 POAG patients has been designed to evaluate the efficacy of topical combination of vitamin E and CoQ10 (CoQun ® ) [ 189 ].…”

Section: Coenzyme Q10mentioning

confidence: 99%

Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma

et al. 2020

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Glaucoma, a leading cause of irreversible blindness worldwide, is an optic neuropathy characterized by the progressive death of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is recognized as the main risk factor. Despite effective IOP-lowering therapies, the disease progresses in a significant number of patients. Therefore, alternative IOP-independent strategies aiming at halting or delaying RGC degeneration is the current therapeutic challenge for glaucoma management. Here, we review the literature on the neuroprotective activities, and the underlying mechanisms, of natural compounds and dietary supplements in experimental and clinical glaucoma.

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Section: Coenzyme Q10mentioning

confidence: 99%

Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma

et al. 2020

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“…Indeed, a clinical study reported that treatment with CoQ10 and vitamin E, in addition to β-blockers, in POAG patients improved pattern electroretinogram and visual evoked potential, indicative of the beneficial effects of CoQ10 and vitamin E on the inner retinal function and visual cortical responses [70]. Further randomized clinical trials in POAG patients to evaluate the effects of CoQ10 and vitamin E in an oral formulation or an eye drop are currently in progress (NCT04038034; NCT03611530) [71]. These trials are looking at the additional effects of CoQ10 and vitamin E to hypotensive drugs and the outcome is awaited.…”

Section: Coenzyme Q10mentioning

confidence: 99%

Suppression of Oxidative Stress as Potential Therapeutic Approach for Normal Tension Glaucoma

et al. 2020

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Glaucoma is a neurodegenerative disease of the eye, which involves degeneration of retinal ganglion cells (RGCs): the output neurons of the retina to the brain, which with their axons comprise the optic nerve. Recent studies have shown the possible involvement of oxidative stress in the pathogenesis of glaucoma, especially in the subtype of normal tension glaucoma. Basic experiments utilizing rodent and primate models of glaucoma revealed that antioxidants protect RGCs under various pathological conditions including glutamate neurotoxicity and optic nerve injury. These results suggested that existing drugs and food factors may be useful for prevention and hence therapy of glaucoma. In this review, we highlight some therapeutic candidates, particularly those with antioxidant properties, and discuss the therapeutic potential of RGC protection by modulating gene expressions that prevent and ameliorate glaucoma.

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“…In a study of 43 patients with open-angle glaucoma associated with CoQ10 and vitamin E supplementation, Parisi et al [ 56 ] found improvement in retinal function followed by an increase in visual cortical responses. The first randomized, double-blind controlled-fashion study in 612 individuals with glaucoma is currently underway to investigate the neuroprotective effects of CoQ10 and Vit E [ 108 ]. For another MN, CARN, Calandrella et al [ 109 ] reported its neuroprotective, antiapoptotic, and antioxidant effects in a glaucoma rat model.…”

Section: The Case Of Optic Neuropathiesmentioning

confidence: 99%

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

Pagano

Pallardó

Lyakhovich

et al. 2020

IJMS

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A number of aging-related disorders (ARD) have been related to oxidative stress (OS) and mitochondrial dysfunction (MDF) in a well-established body of literature. Most studies focused on cardiovascular disorders (CVD), type 2 diabetes (T2D), and neurodegenerative disorders. Counteracting OS and MDF has been envisaged to improve the clinical management of ARD, and major roles have been assigned to three mitochondrial cofactors, also termed mitochondrial nutrients (MNs), i.e., α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and carnitine (CARN). These cofactors exert essential–and distinct—roles in mitochondrial machineries, along with strong antioxidant properties. Clinical trials have mostly relied on the use of only one MN to ARD-affected patients as, e.g., in the case of CoQ10 in CVD, or of ALA in T2D, possibly with the addition of other antioxidants. Only a few clinical and pre-clinical studies reported on the administration of two MNs, with beneficial outcomes, while no available studies reported on the combined administration of three MNs. Based on the literature also from pre-clinical studies, the present review is to recommend the design of clinical trials based on combinations of the three MNs.

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Evaluating the Effects of an Ophthalmic Solution of Coenzyme Q10 and Vitamin E in Open-Angle Glaucoma Patients: A Study Protocol

Cited by 28 publications

References 27 publications

Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma

Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma

Suppression of Oxidative Stress as Potential Therapeutic Approach for Normal Tension Glaucoma

Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures

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