Evaluating the effect of screening dual HLA-A*31:01 and HLA-B*15:02 alleles by multiplex real-time PCR technique on reducing the risk of Carbamazepine-induced hypersensitivity reactions
Abstract:HLA-A*31:01 and HLA-B*15:02 are strongly associated with Carbamazepine (CBZ)-induced severe cutaneous adverse reactions (SCARs). As a result, it is recommended to screen these two alleles before CBZ therapy to reduce the risk of drug allergy. In this study, the authors applied the simultaneous screening test for HLA-A*31:01 and HLA-B*15:02 alleles by multiplex real-time PCR Taqman LNA probe with high sensitivity and specificity in 35 patients that were diagnosed with neurological diseases. Amo… Show more
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