Evaluating the effect of ozone in UV induced skin damage

Ferrara, Francesca; Pambianchi, Erika; Woodby, Brittany; Messano, Nicolò; Therrien, Jean-Philippe; Pecorelli, Alessandra; Canella, Rita; Valacchi, Giuseppe

doi:10.1016/j.toxlet.2020.11.023

Cited by 28 publications

(42 citation statements)

References 99 publications

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“…The correlation between oxidative stress and inflammation in the skin induced by pollutants has been extensively described in the literature [ 51 , 52 , 53 ]. Pollutants can initiate oxidative and inflammatory reactions within the cutaneous tissue, where an ox-inflammatory status further induces cutaneous damage [ 54 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

Ethosomes and Transethosomes for Mangiferin Transdermal Delivery

et al. 2021

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Mangiferin is a natural glucosyl xanthone with antioxidant and anti-inflammatory activity, making it suitable for protection against cutaneous diseases. In this study ethosomes and transethosomes were designed as topical delivery systems for mangiferin. A preformulation study was conducted using different surfactants in association with phosphatidylcholine. Vesicle dimensional distribution was monitored by photon correlation spectroscopy, while antioxidant capacity and cytotoxicity were respectively assessed by free radical scavenging analysis and MTT on HaCaT keratinocytes. Selected nanosystems were further investigated by cryogenic transmission electron microscopy, while mangiferin entrapment capacity was evaluated by ultracentrifugation and HPLC. The diffusion kinetics of mangiferin from ethosomes and transethosomes evaluated by Franz cell was faster in the case of transethosomes. The suitability of mangiferin-containing nanovesicles in the treatment of skin disorders related to pollutants was investigated, evaluating, in vitro, the antioxidant and anti-inflammatory effect of ethosomes and transethosomes on human keratinocytes exposed to cigarette smoke as an oxidative and inflammatory challenger. The ability to induce an antioxidant response (HO-1) and anti-inflammatory status (IL-6 and NF-kB) was determined by RT-PCR and immunofluorescence. The data demonstrated the effectiveness of mangiferin loaded in nanosystems to protect cells from damage. Finally, to gain insight into the keratinocytes’ uptake of ethosome and transethosome, transmission electron microscopy analyses were conducted, showing that both nanosystems were able to pass intact within the cells.

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Section: Resultsmentioning

confidence: 99%

Ethosomes and Transethosomes for Mangiferin Transdermal Delivery

et al. 2021

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“…UV may act synergistically with particulate matter, causing an acute skin response with increased tissue peroxidation and decreased cutaneous α‐tocopherol causing additive oxidative stress in the stratum corneum 73,74 . Ozone, PM and UV radiation synergistically increased oxidative stress and oxinflammation changes in human skin explants 59,64 …”

Section: Biological and Clinical Effects Of Distinct Skin Stressorsmentioning

confidence: 99%

“…Among air pollutants, ozone is one of the most toxic due to its unstable structure and is able to initiate oxidative reactions and activate inflammatory response, leading to the onset of several skin conditions. 58 , 59 In vivo and in vitro studies have shown that short‐term acute exposure to ozone impacts skin defences by production of ROS, biomolecule oxidation (lipid peroxidation and protein carbonylation), depletion of cellular antioxidant defences, cell stress and cytotoxicity. 1 , 60 , 61 , 62 Ozone can induce inflammasome activation in a redox dependent manner in a mouse model, which may play a role in pollution‐induced inflammatory skin conditions.…”

Section: Biological and Clinical Effects Of Distinct Skin Stressorsmentioning

confidence: 99%

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Adult skin acute stress responses to short‐term environmental and internal aggression from exposome factors

Passeron

Zouboulis

Tan

et al. 2021

Acad Dermatol Venereol

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Exposome factors that lead to stressed skin can be defined as any disturbance to homeostasis from environmental (meteorological factors, solar radiation, pollution or tobacco smoke) and/or internal exposure (unhealthy diet, hormonal variations, lack of sleep, psychosocial stress). The clinical and biological impact of chronic exposome effects on skin functions has been extensively reviewed, whereas there is a paucity of information on the impact of short‐term acute exposure. Acute stress, which would typically last minutes to hours (and generally no more than a week), provokes a transient but robust neuroendocrine‐immune and tissue remodelling response in the skin and can alter the skin barrier. Firstly, we provide an overview of the biological effects of various acute stressors on six key skin functions, namely the skin physical barrier, pigmentation, defences (antioxidant, immune cell‐mediated, microbial and microbiome maintenance), structure (extracellular matrix and appendages), neuroendocrine and thermoregulation functions. Secondly, we describe the biological and clinical effects on adult skin from individual exposome factors that elicit an acute stress response and their consequences in skin health maintenance. Clinical manifestations of acutely stressed skin may include dry skin that might accentuate fine lines, oily skin, sensitive skin, pruritus, erythema, pale skin, sweating, oedema and flares of inflammatory skin conditions such as acne, rosacea, atopic dermatitis, pigmentation disorders and skin superinfection such as viral reactivation. Acute stresses can also induce scalp sensitivity, telogen effluvium and worsen alopecia.

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“…In the 21st century, one of the major environmental risks to human health is represented by air pollution, causing a reduction of life expectancy by almost 2 years on worldwide average [ 1 ]. Indeed, it has been demonstrated that many respiratory diseases, cardiovascular dysfunctions, as well as skin pathologies can be induced by toxic substances produced by humans and accidentally delivered into the atmosphere [ 2 , 3 , 4 ]. These volatile organic compounds contribute to secondary pollutant formation, such as the tropospheric ozone O 3 [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation

et al. 2021

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Human skin is dramatically exposed to toxic pollutants such as ozone. To counteract the skin disorders induced by the air pollution, natural antioxidants such as mangiferin could be employed. A formulative study for the development of vesicular systems for mangiferin based on phosphatidylcholine and the block copolymer pluronic is described. Plurethosomes were designed for mangiferin transdermal administration and compared to ethosome and transethosome. Particularly, the effect of vesicle composition was investigated on size distribution, inner and outer morphology by photon correlation spectroscopy, small angle X-ray diffraction, and transmission electron microscopy. The potential of selected formulations as vehicles for mangiferin was studied, evaluating encapsulation efficiency and in vitro diffusion parameters by Franz cells. The mangiferin antioxidant capacity was verified by the 2,2-diphenyl-1-picrylhydrazyl assay. Vesicle size spanned between 200 and 550 nm, being influenced by phosphatidylcholine concentration and by the presence of polysorbate or pluronic. The vesicle supramolecular structure was multilamellar in the case of ethosome or plurethosome and unilamellar in the case of transethosome. A linear diffusion of mangiferin in the case of ethosome and transethosomes and a biphasic profile in the case of plurethosomes indicated the capability of multilamellar vesicles to retain the drug more efficaciously than the unilamellar ones. The antioxidant and anti-inflammatory potential effect of mangiferin against pollutants was evaluated on 3D human skin models exposed to O3. The protective effect exerted by plurethosomes and transethosomes suggests their possible application to enhance the cutaneous antioxidant defense status.

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Evaluating the effect of ozone in UV induced skin damage

Cited by 28 publications

References 99 publications

Ethosomes and Transethosomes for Mangiferin Transdermal Delivery

Ethosomes and Transethosomes for Mangiferin Transdermal Delivery

Adult skin acute stress responses to short‐term environmental and internal aggression from exposome factors

“Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation

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