Evaluating the effect of kidney function on brain volumes and dementia risk in the UK Biobank

Huang, Xiaxuan; Yuan, Shiqi; Ling, Yitong; Cheng, Hongtao; Tan, Shanyuan; Xu, Anding; Lyu, Jun

doi:10.1016/j.archger.2023.105157

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…If unmet, time-dependent covariates were incorporated in all models. To control potential confounders, potential dementia risk factors were incorporated as covariates based on prior research ( 33 ), and these covariates were sequentially adjusted in the models. Increased age and being female were significantly linked to an elevated risk of dementia, with Model 1 aiming to determine if folate/folic acid supplementation was associated with this risk, independently of age and sex.…”

Section: Methodsmentioning

confidence: 99%

Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants

Ling,

Yuan,

Huang

et al. 2023

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

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Previous researchers have tried to explore the association between folate/folic acid intake and dementia incidence, but the results remain controversial. We evaluated the associations of folate/folic acid supplementation alone and in combination with other B vitamins on dementia risk and brain structure. A total of 466,224 UK Biobank participants were investigated. Cox proportional hazards models were used to assess the associations between folate/folic acid supplementation status and the risk of Alzheimer's disease (AD) and vascular dementia (VD). Multivariable linear regression models were employed to evaluate the association between folate/folic acid supplementation status and brain structure. In the final model, folate/folic acid supplementation alone was significantly associated with a higher risk of AD (hazard ratio [HR] =1.34, 95% confidence interval [CI] =1.06 to 1.69, p=0.015) and VD (HR=1.61, 95% CI=1.21 to 2.13, p=0.001). Folate/folic acid supplementation alone was associated with a reduction in the hippocampus (β= -95.25 mm3, 95% CI= -165.31 to -25.19 mm3, p=0.014) and amygdala (β= -51.85 mm3, 95% CI= -88.02 to -15.68 mm3, p=0.012). The risk of AD and VD, as well as brain structure, in the group with combined folate/folic acid supplementation and other B vitamins did not show a statistically significant difference compared to the reference group (all p>0.05). Folate/folic acid supplementation alone is significantly associated with a higher risk of AD and VD, as well as adverse alterations in brain structure. However, when combined with other B vitamins, these detrimental effects can be counteracted.

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Section: Methodsmentioning

confidence: 99%

Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants

Ling,

Yuan,

Huang

et al. 2023

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

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“… 3 Before their widespread implementation, it is important to validate these biomarkers in different populations and medical comorbidities. Chronic kidney disease (CKD), an independent risk factor for cognitive impairment and dementia 4 , 5 affects the levels of AD blood biomarkers. Reduced kidney function or estimated glomerular filtration rate (eGFR) may increase the levels of these biomarkers.…”

Section: Introductionmentioning

confidence: 99%

Changes in Alzheimer's disease blood biomarkers in kidney failure before and after kidney transplant

Blankenship,

Yoksh,

Kueck

et al. 2024

Alz & Dem Diag Ass & Dis Mo

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INTRODUCTIONAlzheimer's disease (AD) blood biomarkers show promise for clinical diagnosis but their reliability in chronic kidney disease (CKD) is debated. This study investigates the impact of kidney transplant (KT) on AD biomarkers in CKD.METHODSWe assessed AD biomarkers in 46 CKD patients pre‐KT, at 12 weeks and 12 months post‐KT, with baseline measures from 13 non‐CKD controls. Using linear mixed models, we examined associations with participant groups, estimated glomerular filtration rate (eGFR) and cognition.RESULTSCKD patients showed elevated levels of neurofilament light (117 ± 72 vs. 11 ± 5 pg/mL), phosphorylated tau 181 (75 ± 42 vs. 13 ± 8 pg/mL), glial fibrillary acidic protein (193 ± 127 vs. 94 ± 39 pg/mL), amyloid β 42 (17 ± 5 vs. 5 ± 1 pg/mL), and amyloid β 40 (259 ± 96 vs. 72 ± 17 pg/mL) compared to controls. Post‐KT, biomarker levels approached normal with improved eGFR, paralleled by enhanced cognitive function.DISCUSSIONAD blood biomarker elevations in CKD are reversible with improved kidney function through KT.Highlights AD biomarker levels are extremely high in severe CKD. AD biomarker levels are higher in patients with kidney failure on dialysis when compared to CKD patients not on dialysis. These elevations in AD biomarker levels in kidney failure are reversable and decrease dramatically after kidney transplantation. The change in biomarker levels after transplantation align with changes in kidney function. The change in biomarker levels after transplantation align with changes in cognitive function.

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Evaluating the effect of kidney function on brain volumes and dementia risk in the UK Biobank

Cited by 2 publications

References 35 publications

Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants

Associations of Folate/Folic Acid Supplementation Alone and in Combination With Other B Vitamins on Dementia Risk and Brain Structure: Evidence From 466 224 UK Biobank Participants

Changes in Alzheimer's disease blood biomarkers in kidney failure before and after kidney transplant

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