This study aimed to investigate of the relationship between coronaphobia and compliance with isolation precautions of nurses on the front line in the fight combating coronavirus disease-2019 (COVID-19) pandemic. Material and Methods: This cross-sectional study was conducted via a web-based questionnaire with 614 nurses working in the pandemic wards from July to November 2020. Data were obtained by using the Personal Information Form, the COVID-19 Phobia Scale, and the Isolation Precautions Compliance Scale. Results: The average age of the nurses was 28.13±5.32 years and 71.2% of them were women. The COVID-19 Phobia Scale mean score of the participants was found to be 55.15±13.26, and the mean score of the Isolation Precautions Compliance Scale was 74.18±9.64. Isolation Precautions Compliance Scale total mean scores of the nurses were found to be significantly positively associated with psychological subscale scores (p<0.001) on COVID-19 Phobia Scale; and significantly negatively associated with psycho-somatic sub-scale scores (p<0.001) and economic sub-scale scores (p<0.001). However, no statistically significant association was found between the COVID-19 Phobia Scale total mean scores and the Isolation Precautions Compliance Scale total mean scores of the nurses (p=0.084). Conclusion: This study showed that there was no relationship between nurses' coronavirus phobia and compliance with isolation measures. However, as nurses' psychological phobia related to coronavirus increased, their compliance with isolation measures increased, and as their psychosomatic and economic phobias increased, their compliance with isolation measures decreased.