Evaluating the bio-application of biomacromolecule of lignin-carbohydrate complexes (LCC) from wheat straw in bone metabolism via ROS scavenging

Zheng, Liming; Yu, Pengjun; Zhang, Hongjie; Wang, Peng; Yan, Wenjin; Guo, Baosheng; Huang, Caoxing; Jiang, Qing

doi:10.1016/j.ijbiomac.2021.01.103

Cited by 76 publications

(40 citation statements)

References 39 publications

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“…Recently, nanomaterials, such as nanocellulose, nanogel, and nano-membranes, have brought innovation in biomedical application due to their excellent biocompatibility, physicochemical properties and ease of functionalization (Nie et al, 2018a,b;Lu et al, 2020;Wang P. et al, 2020;Zhang et al, 2021). Generally, various extracts and inorganic substances that have ability to scavenge free radicals can inhibit inflammation casing by bacterias (Huang et al, 2018;Dong et al, 2020;Pei et al, 2020;Gu et al, 2021;Zheng et al, 2021), among which MgO nanoparticles have attracted considerable attention in tissue engineering due to their multifold effects on accelerating osteogenic differentiation of biological cells and inhibiting bacterial activity (Khandaker et al, 2013;Ke et al, 2019). Liu et al (2020) reported that PLA/gelatin periodontal membrane fabricated by electrospinning biodegradable polymers with MgO nanoparticles demonstrated a dose-dependent magnesium ion-induced osteogenic activity of rabbit bone marrow stem cells (rBMSCs).…”

Section: Introductionmentioning

confidence: 99%

MgO Nanoparticles-Incorporated PCL/Gelatin-Derived Coaxial Electrospinning Nanocellulose Membranes for Periodontal Tissue Regeneration

Peng

Ren

Zhang

et al. 2021

Front. Bioeng. Biotechnol.

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Electrospinning technique has attracted considerable attention in fabrication of cellulose nanofibrils or nanocellulose membranes, in which polycaprolactone (PCL) could be used as a promising precursor to prepare various cellulose nanofibril membranes for periodontal tissue regeneration. Conventional bio-membranes and cellulose films used in guided tissue regeneration (GTR) can prevent the downgrowth of epithelial cells, fibroblasts, and connective tissue in the area of tooth root but have limitations related to osteogenic and antimicrobial properties. Cellulose nanofibrils can be used as an ideal drug delivery material to encapsulate and carry some drugs. In this study, magnesium oxide (MgO) nanoparticles-incorporated PCL/gelatin core-shell nanocellulose periodontal membranes were fabricated using coaxial electrospinning technique, which was termed as Coaxial-MgO. The membranes using single-nozzle electrospinning technique, namely Blending-MgO and Blending-Blank, were used as control. The morphology and physicochemical property of these nanocellulose membranes were characterized by scanning electron microscopy (SEM), energy-dispersive spectrum of X-ray (EDS), transmission electron microscopy (TEM), contact angle, and thermogravimetric analysis (TGA). The results showed that the incorporation of MgO nanoparticles barely affected the morphology and mechanical property of nanocellulose membranes. Coaxial-MgO with core-shell fiber structure had better hydrophilic property and sustainable release of magnesium ion (Mg2+). CCK-8 cell proliferation and EdU staining demonstrated that Coaxial-MgO membranes showed better human periodontal ligament stem cells (hPDLSCs) proliferation rates compared with the other group due to its gelatin shell with great biocompatibility and hydrophilicity. SEM and immunofluorescence assay results illustrated that the Coaxial-MgO scaffold significantly enhanced hPDLSCs adhesion. In vitro osteogenic and antibacterial properties showed that Coaxial-MgO membrane enhanced alkaline phosphatase (ALP) activity, formation of mineralized nodules, osteogenic-related genes [ALP, collagen type 1 (COL1), runt-related transcription factor 2 (Runx2)], and high antibacterial properties toward Escherichia coli (E. coli) and Actinobacillus actinomycetemcomitans (A. a) when compared with controls. Our findings suggested that MgO nanoparticles-incorporated coaxial electrospinning PCL-derived nanocellulose periodontal membranes might have great prospects for periodontal tissue regeneration.

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Section: Introductionmentioning

confidence: 99%

MgO Nanoparticles-Incorporated PCL/Gelatin-Derived Coaxial Electrospinning Nanocellulose Membranes for Periodontal Tissue Regeneration

Peng

Ren

Zhang

et al. 2021

Front. Bioeng. Biotechnol.

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“…(2) As the lignin content increased in the samples, the possibility of attraction among the nanofibrils decreased, contributing to the separation of nanofibrils. Consequently, the measured data decreased with the increase of lignin content (Ferrer et al, 2012;Dong et al, 2020b;Pei et al, 2020;Zheng et al, 2021a).…”

Section: Morphologies Of Lcnfs and Lnpsmentioning

confidence: 96%

Valorization of Enzymatic Hydrolysis Residues from Corncob into Lignin-Containing Cellulose Nanofibrils and Lignin Nanoparticles

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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As a kind of biomass waste, enzymatic hydrolysis residues (EHRs) are conventionally burned or just discarded, resulting in environmental pollution and low economic benefits. In this study, EHRs of corncob residues (CCR) were used to produce high lignin-containing cellulose nanofibrils (LCNFs) and lignin nanoparticles (LNPs) through a facile approach. The LCNFs and LNPs with controllable chemical compositions and properties were produced by tuning the enzymolysis time of CCR and the followed homogenization. The morphology, thermal stability, chemical and crystalline structure, and dispersibility of the resultant LCNFs and LNPs were further comprehensively investigated. This work not only promotes the production of lignocellulose-based nanomaterials but also provides a promising utilization pathway for EHRs.

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“…To establish the method to isolate the small extracellular vesicle from the serum by the Total Exosome Isolation Reagent (from serum) (Cat# 4478360, Invitrogen, United States) according to the manufacturer's protocol, the isolated small extracellular vesicles were characterized by transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Western blotting as previously described (Jiao et al, 2020) (Zheng et al, 2021). Briefly, the TEM was performed by a JEM-1011 scanning transmission electron microscope (Hitachi, Tokyo, Japan).…”

Section: Serum Small Extracellular Vesicle Isolation and Rna Extractionmentioning

confidence: 99%

Two Small Extracellular Vesicle sRNAs Derived From Mycobacterium tuberculosis Serve as Diagnostic Biomarkers for Active Pulmonary Tuberculosis

Jiang

et al. 2021

Front. Microbiol.

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The rapid diagnosis of tuberculosis (TB) is of great significance for the control and treatment of TB. However, TB remains a major healthy, social, and economic burden worldwide because of the lack of ideal diagnostic biomarkers. Mycobacterium tuberculosis (M. tuberculosis)-encoded small RNA (sRNA) is a class of regulation small RNA. Several studies have identified M. tuberculosis encoded-sRNAs in the serum/plasm of M. tuberculosis-infected patients. Small extracellular vesicles are small membrane vesicles secreted by many cell types during physiological and pathological conditions. Recent evidence has indicated that most of the nucleic acids in the serum/plasma are packaged in the small extracellular vesicles and could serve as ideal diagnostic biomarkers. In this study, we attempted a novel approach for TB diagnosis: targeting small extracellular vesicles M. tuberculosis encoded sRNA (sRNA) by qRT-PCR. The results showed that M. tuberculosis-encoded ASdes and MTB-miR5 only existed in tuberculosis patients and have the potential to serve as a sensitive and accurate methodology for TB diagnosis.

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Evaluating the bio-application of biomacromolecule of lignin-carbohydrate complexes (LCC) from wheat straw in bone metabolism via ROS scavenging

Cited by 76 publications

References 39 publications

MgO Nanoparticles-Incorporated PCL/Gelatin-Derived Coaxial Electrospinning Nanocellulose Membranes for Periodontal Tissue Regeneration

MgO Nanoparticles-Incorporated PCL/Gelatin-Derived Coaxial Electrospinning Nanocellulose Membranes for Periodontal Tissue Regeneration

Valorization of Enzymatic Hydrolysis Residues from Corncob into Lignin-Containing Cellulose Nanofibrils and Lignin Nanoparticles

Two Small Extracellular Vesicle sRNAs Derived From Mycobacterium tuberculosis Serve as Diagnostic Biomarkers for Active Pulmonary Tuberculosis

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