Evaluating the associations of adult heel BMD with birth weight and growth parameters at age 10 in UK Biobank cohort

Yang, Xuena; Ye, Jing; Cheng, Bolun; Cheng, Shiqiang; Liu, Li; Meng, Peilin; Liang, Chujun; Yao, Yao; Wen, Yan; Zhang, Zhen; Li, Chune; Zhang, Huijie; Chen, Yujing; Zhang, Jingxi; Pan, Chuyu; Jia, Yumeng; Zhang, Feng

doi:10.1016/j.bone.2021.116038

Cited by 3 publications

(2 citation statements)

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“…Alkaline phosphatase is an important enzyme that is produced during the bone formation cycle and is therefore considered an excellent indicator of bone formation activity ( Shidara and Inaba, 2009 ; Lowe et al, 2017 ) and BMD ( Yang et al, 2021 ). In addition, procollagen type 1 N-terminal propeptide (P1NP) has been proven to be a more sensitive bone biomarker to determine the bone formation rate in osteoporosis ( Kuo and Chen, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Estradiol and zinc-doped nano hydroxyapatite as therapeutic agents in the prevention of osteoporosis; oxidative stress status, inflammation, bone turnover, bone mineral density, and histological alterations in ovariectomized rats

et al. 2022

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Osteoporosis (OP) is a serious health problem, and the most popular therapeutic strategy for OP is hormone replacement (estrogen); however, it increases the risk of reproductive cancers. Hydroxyapatite (HA) nanoparticles have a similar chemical structure to the bone mineral component and can be used as a new remedy for OP. This study was designed to investigate the osteoporosis-protective potential of nano zinc hydroxyapatite (ZnHA-NPs) and/or estradiol (E2) combined therapy. A total of 35 adult female rats were assigned into five groups (n = 7): 1) control group; 2) ovariectomized group (OVX); 3) OVX received oral estradiol replacement therapy (OVX/E2); 4) OVX received ZnHA replacement therapy (OVX/ZnHA); and 5) OVX received both estradiol and ZnHA-NPs combined therapy (OVX/E2+ZnHA). After 3 months of treatment, serum bone markers and estrogen level, oxidative/antioxidant, and inflammatory cytokines were determined. Additionally, femoral expression of estrogen receptors alpha and beta (ESR1; ESR2), receptor activator of nuclear factor-kappa B (RANKL) ligand, osteoprotegerin (OPG), bone mineral density (BMD), histological alterations, and immunohistochemical expression of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) were assessed. ALP, PINP, Ca, and P concentrations improved significantly (p < 0.05) in all treatment groups, especially in the OVX/E + ZnHA group. MDA and NO were higher in OVX rats, while SOD activity and GSH were lower (p < 0.05). E2 alone or with ZnHA-NPs restored the estimated antioxidant molecules and cytokines toward normal levels in OVX rats (p < 0.05). On the other hand, E2 and ZnHA increased OPG and OC expression in femurs while decreasing ESR1, ESR2, and NF-kB expression (p < 0.05). The combination treatment was superior in the restoration of normal femoral histoarchitecture and both cortical and trabecular BMD (p < 0.05). Overall, the combined therapy of OVX/E2+ZnHA was more effective than the individual treatments in attenuating excessive bone turnover and preventing osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Estradiol and zinc-doped nano hydroxyapatite as therapeutic agents in the prevention of osteoporosis; oxidative stress status, inflammation, bone turnover, bone mineral density, and histological alterations in ovariectomized rats

et al. 2022

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“…Centralization refers to the original data minus its mean, and standardization is defined as the centralized data divided by the standard deviation (SD) of the original data [ 37 ]. In this study, CRP, SII, coffee, vitamin D, tobacco, alcohol, and heel BMD were centralized and standardized before regression analysis, with P < 5.21 × 10 −4 (four lifestyle factors × two validation factors × stratified analysis × three populations × two interaction factors) as the threshold of significance after correction for multiple testing.…”

Section: Methodsmentioning

confidence: 99%