Evaluating the Antivirulence Effects of New Thiazolidinedione Compounds Against <i>Pseudomonas aeruginosa</i> PAO1

Shakour, Neda; Taheri, Elaheh; Rajabian, Fatemeh; Tarighi, Saeed; Soheili, Vahid; Hadizadeh, Farzin

doi:10.1089/mdr.2022.0134

Cited by 7 publications

(4 citation statements)

References 60 publications

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“…respectively. It is worth noticing that tested compounds did not show any toxicity against human dermal fibroblasts and 4T1 cells (viability higher than 90%) [71].…”

Section: Key Structural Features Of Thiazolidine-4-ones Responsible F...mentioning

confidence: 93%

“…As reported by Shakour et al, TZD-imidazole hybrids ( 57a – 57c ) (blue color in Figure 22 ) showed a biofilm reduction of 87.94% ( 57a ) for the P. aeruginosa PAO1 strain, as well as of 30.53% ( 57b ) and 44.65% ( 57c ) for the P. aeruginosa 1074 and P. aeruginosa 1707 strains, respectively. It is worth noticing that tested compounds did not show any toxicity against human dermal fibroblasts and 4T1 cells (viability higher than 90%) [ 71 ].…”

Section: Thiazolidin-4-ones With Antibiofilm Propertiesmentioning

confidence: 99%

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Thiazolidin-4-Ones as a Promising Scaffold in the Development of Antibiofilm Agents—A Review

Trotsko

2023

IJMS

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Thiazolidin-4-ones have a broad range of medical and clinical implementation, which is important for pharmaceutical and medicinal chemistry. This heterocyclic core has been reported to possess a diversity of bioactivities, including antimicrobial and antibiofilm-forming potential. The resistance of biofilms to antibiotics or disinfectants is a serious medical problem. Therefore, there is a natural need to discover new effective structures with properties that inhibit biofilm formation. This review aims to analyze the antibiofilm features of thiazolidin-4-ones described in the literature over the last two decades. The information gathered in this review could benefit the rational design of new effective antibiofilm small molecules with thiazolidin-4-one cores.

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“…respectively. It is worth noticing that tested compounds did not show any toxicity against human dermal fibroblasts and 4T1 cells (viability higher than 90%) [71].…”

Section: Key Structural Features Of Thiazolidine-4-ones Responsible F...mentioning

confidence: 93%

Section: Thiazolidin-4-ones With Antibiofilm Propertiesmentioning

confidence: 99%

Thiazolidin-4-Ones as a Promising Scaffold in the Development of Antibiofilm Agents—A Review

Trotsko

2023

IJMS

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“…MOE program developed the 3D format, and the docking was accomplished utilizing the triangle matcher approach as placement and the London DG score with one hundred poses. The GBWI/WSA DG was re ned using the rigid receptor approach, and ve postures were used to score it 49,59,61 . For six compounds (Canagli ozin, Empagli ozin, Dapagli ozin, Ertugli ozin, and compounds 306 and 580), docking was carried out.…”

Section: Docking Studymentioning

confidence: 99%

“…The Protein Data Bank was used to nd the crystal structure of SGLT2i with PDB ID: 7vsi and resolution 2.95. The water molecules were removed, the receptor was attached to polar hydrogen atoms according to the appropriate ionization states, and the complex was stored in the format of PDB 59,60 . ChemDraw Ultra (http://www.…”

Section: Docking Studymentioning

confidence: 99%

In silico discovery of potential sodium–glucose cotransporter-2 inhibitors from natural products for Prevent Kidney Failure in Patients with Type 2 Diabetes

Shakour

Hoseinpoor

Iranshahi

et al. 2023

Preprint

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Associated with Type 2 diabetes (T2DM), renal dysfunction contributes to an increased death rate. Consequently, it would appear that preventing the advancement of renal disease is crucial in the treatment of diabetic patients. SGLT2 inhibitors have been linked to reduced renal mortality, decreased hospitalization, and slowed the progression of renal impairment and albuminuria. The objective of this study was aimed to identify natural SGLT2 inhibitors using an in silico evaluation of the compounds of zinc database using structure-based virtual screening. Using pharmacophore modelling of the standard drug, a total of 1,1336 natural compounds that have the potential to act as SGLT2 inhibitors were identified; six of these compounds, 580, 1131, 212, 357, 822, and 306, had a similar docking affinity to the four known SGLT2 inhibitors. The top two finds, 580 and 306, were chosen due to the convenience of the pharmacokinetic characteristics from the absorption, distribution, metabolism and excretion (ADME), oral bioavailability, and parameters from molecular dynamics simulation (MD). Compound 580 was discovered as a potential treatment candidate after estimations of the metabolic processes and cardiotoxicity. This study may assist in the advancement of both in vitro and in vivo validation, as well as the development of new SGLT2 inhibitors.

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Modification of activated carbon to enhance the absorption of PCDD/F and dl-PCBs emissions in flue gas in South Africa

Themba,

Sibali,

Chokwe

2024

Discov Appl Sci

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Activated carbon (AC) adsorption is commonly used for polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) removal from flue gas. However, the AC available in the market predominantly possesses a substantial specific surface area and numerous micropores leading to significant variations in their adsorption characteristics. In this study, three types of activated carbon (AC) impregnated with different activating agents, namely K2CO3, KOH, and H3PO4 were evaluated for their effectiveness in removing PCDD/Fs and dl-PCBs compounds. For dl-PCBs, AC impregnated with H3PO4 resulted in a substantial reduction of PCB concentrations with an impressive 98% reduction achieved. Impregnation with KOH proved even more effective attaining a remarkable 99% reduction. In contrast, impregnation with K2CO3 while still effective achieved a slightly lower reduction rate of 95%. For PCDD/F, LACH3PO4 showed selectivity in achieving high reductions across both CDD and CDF congeners however proved effective in reducing the ∑PCCDF from 403.94 ng/Nm3 to 3.463 ng/Nm3 and ∑TEQ from 41.34 ng I-TEQ/Nm3 to 0.35 ng I-TEQ Nm3. LACKOH proved effective in reducing the ∑PCCDF from 540.45 ng/Nm3 to 0.25 ng/Nm3 and ∑TEQ from 57.42 ng I-TEQ/Nm3 to 0.12 ng I-TEQ Nm3 obtaining the overall removal efficiency of 99.5%. While the LACKOH injections were successful in the absorption of PCDD/Fs from the gas phase, it was observed that certain PCDD/F congeners became desorbed and entrapped within the ash necessitating further treatment of the ash residue. The ash underwent a thermal treatment first at 300 °C and 500 °C. The thermal treatment at 500 °C achieved a remarkable degradation of 99.7% removal efficiency rendering the ash and residue safe for disposal in a landfill site. Graphical Abstract

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Evaluating the Antivirulence Effects of New Thiazolidinedione Compounds Against Pseudomonas aeruginosa PAO1

Cited by 7 publications

References 60 publications

Thiazolidin-4-Ones as a Promising Scaffold in the Development of Antibiofilm Agents—A Review

Thiazolidin-4-Ones as a Promising Scaffold in the Development of Antibiofilm Agents—A Review

In silico discovery of potential sodium–glucose cotransporter-2 inhibitors from natural products for Prevent Kidney Failure in Patients with Type 2 Diabetes

Modification of activated carbon to enhance the absorption of PCDD/F and dl-PCBs emissions in flue gas in South Africa

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