Evaluating the antifertility potential of an aqueous extract from Cassia fistula seeds in male rats

Chauhan, Akshansha; Agarwal, Mudit

doi:10.1016/j.fertnstert.2009.09.001

Cited by 16 publications

(8 citation statements)

References 21 publications

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“…In the present study, we have made an attempt to demonstrate the effect of SAF on the reproductive potential of male mice by monitoring its effect on changes in body weight, TSI, hematological parameters, seminal parameters, testosterone level, lipid peroxidation, and tissue histology. The body weight profile of SAF-treated mice showed no significant changes and these findings are in line with the study by Reddy et al [10] and Chauhan and Agarwal [11]; wherein, no change was reported in the body weight of the male rats treated with a microbial peptide nisin and extract of Cassia fistula . Furthermore, evaluation of TSI (%) of reproductive organs and nonreproductive organs was carried out to investigate their functional status ensuing various experimental conditions, and results of unilateral administration of SAF in right testis revealed no significant changes in %TSI.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Sperm Impairing Factor fromSerratia marcescensas Male Contraceptive in Mouse Model

Chauhan

Prabha

2019

BioMed Research International

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The present study was carried out to assess the contraceptive efficacy of sperm agglutinating factor (SAF) isolated from Serratia marcescens, in male Balb/c mice. Mice were administered via an intratesticular route with different concentrations of SAF, viz., 10, 50, 100, 200, or 400 µg, in the right testis only which served as a test while the left side served as control except otherwise stated. Mice were sacrificed on day 3, 7, 14, 21, 30, 45, 60, and 90 after administration, and results in terms of change in body weight, seminal parameters, tissue somatic indices (TSI), hematological parameters, serum level of testosterone, lipid peroxidation, and histology were studied. The body weight and TSI remained unaffected in all the experimental groups. In case of seminal parameters, the right testis treated with 10 μg, 50 μg, 100 μg, 200 μg, or 400 μg of SAF showed azoospermia up to day 7, 14, 21, 45, and 90, respectively. The hematological indices, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) were found to be unaltered when the group receiving SAF (test) was compared with the groups receiving phosphate buffer saline (control) in the right testis; however, the treatment had a negative effect on the serum level of testosterone. It also affected the oxidative status of the right testis. Furthermore, histological studies revealed hypospermatogenesis and alterations in the seminiferous tubules which included intraepithelial vacuolation and exfoliation in the right side as compared to the left side. Thus, the results suggest that SAF (400 µg) causes suppression of spermatogenesis, without causing apparent toxic effects.

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Section: Discussionsupporting

confidence: 91%

Evaluation of Sperm Impairing Factor fromSerratia marcescensas Male Contraceptive in Mouse Model

Chauhan

Prabha

2019

BioMed Research International

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“…Thus, recent research paradigm focuses on herbal remedies and dietary food supplements as a means of solving health challenges and social problems (Eboetse et al., ; Eisenberg et al., ). However, there is growing experimental evidence indicating that some of these dietary food supplements, fruits, vegetables and seeds have antifertility effects (Abarikwu, Ogunlaja, Otuechere, & Gideon, ; Chauhan & Agarwal, ; Koriem, ). For instance, fenugreek seed‐supplemented diet was reported to induce male infertility by targeting the testes.…”

Section: Introductionmentioning

confidence: 99%

Telfairia occidentalis-supplemented diet induces changes in sperm parameters and testosterone level in rats

2018

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The growing patronage on herbal remedies and formulations from natural products in most developing countries has warranted research into certain health challenges including their antifertility effects. This study assessed the effects of boiled Telfairia occidentalis (TO) seed-supplemented diets on the level of testosterone and semen quality in Wistar rats. Boiled TO seed diets at 10%, 15% and 30% were given to rats for 60 days. Our study showed that sperm quality was impaired as evidenced by the decreased number of motile spermatozoa, epididymal sperm numbers, percentage live/dead ratio and increased numbers of abnormal spermatozoa comparable to control values (p < .05). Feeding of rats with 10% and 15% TO seed-supplemented diets increased testosterone levels nonsignificantly, while in the 30% TO seed diet animals, the level of serum testosterone was found to decrease significantly compared to control values. Furthermore, TO diet caused a nonsignificant increase in the activity of superoxide dismutase and the concentrations of reduced glutathione and malondialdehyde except for the significant increase in malondialdehyde level in the testes of the 10% TO diet group. A nonsignificant decrease in myeloperoxidase activity was also observed in the 10% and 15% but not 30% TO diet group. Histological damages characterised by severe loss of germ cells were more pronounced in the 10% TO diet group. Fourier transform infrared spectroscopy analysis of boiled TO seeds revealed the presence of esters, alkenes, hydroxyl and alcohol functional groups. Thus, boiled TO seed-supplemented diet evoked antifertility effects in rats, and the effects on the toxicity end points investigated were not dose-dependent.

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“…Cassia fistula reversibly suppresses fertility in male rats. Withdrawal of extract restored all the altered parameters, including organ weights, fertility, circulatory level of hormones and tissue biochemistry, to control levels after 120 days (17).…”

Section: Anti-fertilitymentioning

confidence: 92%

Medicinal Properties of Aragvadha (Cassia fistula Linn.)

Sangu¹,

C²,

Sharma³

et al. 2011

IJAM

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Evaluating the antifertility potential of an aqueous extract from Cassia fistula seeds in male rats

Cited by 16 publications

References 21 publications

Evaluation of Sperm Impairing Factor fromSerratia marcescensas Male Contraceptive in Mouse Model

Evaluation of Sperm Impairing Factor fromSerratia marcescensas Male Contraceptive in Mouse Model

Telfairia occidentalis-supplemented diet induces changes in sperm parameters and testosterone level in rats

Medicinal Properties of Aragvadha (Cassia fistula Linn.)

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