Evaluating the anticancer activity and nanoparticulate nature of homeopathic preparations of Terminalia chebula

Wani, Kirtee; Shah, Nilesh; Prabhune, Asmita; Jadhav, Arun Bhargav; Ranjekar, P. K.; Kaul-Ghanekar, Ruchika

doi:10.1016/j.homp.2016.02.004

Cited by 25 publications

(13 citation statements)

References 28 publications

(19 reference statements)

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“…37 The studies performed by this group in the 2010s had a new and different focus: to document pro-apoptotic effects of homeopathic medicines on cancer cells and establish their underlying mechanisms. [40][41][42][43][44][45] In all these cases, they reported positive findings-cytotoxic action, involving several signal 47 The hypothesis that homeopathic medicines only hinder the viability of tumor cells, without any cytotoxic activity on normal ones, was tested by Wani et al, 48 and Frenkel et al, 49 both of which groups analyzed drugs and cancer models included in the Banerjee protocol. Against this evidence, however, Wälchli et al 50 hypothesized and demonstrated that primary cells are fitter to respond to high potencies than cell lines, especially cancer cell lines.…”

Section: Discussionmentioning

confidence: 99%

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Homeopathy in Experimental Cancer Models: A Systematic Review

et al. 2020

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Background Complementary and alternative medicine, including homeopathy, is widely used to improve well-being among cancer patients and reduce adverse effects of conventional treatment. In contrast, there are few studies on the use of homeopathic medicines to treat the disease itself. Yet, evidence of possible effectiveness of homeopathic high dilutions in experimental cancer models has been published during the past 20 years. Aim The aim of the study was to perform a systematic review of fundamental research studies on homeopathic high dilutions in cancer. Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline, we conducted a literature search in the database PubMed for original publications, from 2000 to 2018 and in English, on in vitro and in vivo experimental cancer models testing homeopathic high dilutions. Results Twenty-three articles met the inclusion criteria—14 in vitro, eight in vivo, and one in vitro plus in vivo experimental models. Most studies were from India. Research prominently focused on cytotoxic effects involving apoptotic mechanisms. Intrinsic aspects of homeopathy should be considered in experimental designs to emphasize the specificity of such effects. Conclusion Fundamental research of homeopathy in cancer is still at an early stage and has mainly been performed by a few groups of investigators. The results point to an interference of well-selected homeopathic medicines with cell cycle and apoptotic mechanisms in cancer cells. However, these findings still need independent reproduction.

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Section: Discussionmentioning

confidence: 99%

“…Wani et al 2016 48 40 to 5% alcohol (pre-test); untreated cells (negative). potencies (known as "potency chord") 60 is still an open field for further investigation.…”

Section: Discussionmentioning

confidence: 99%

Homeopathy in Experimental Cancer Models: A Systematic Review

et al. 2020

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“…Toxicodendron pubescens (known in Homeopathy as Rhus toxicodendron ) exhibited anti-inflammatory effect on rat arthritis [59] ; the maximum protective effect was evident in the crude form at 10 mg/kg/day, but significant results were obtained also with Homeopathic dilutions 3c, 6c, 30c, and 200c. Terminalia chebula , which is a component of the Ayurvedic formulation Triphala [60] , showed a dose-dependent anti-proliferative activity against cancer cell lines when tested as low dilutions or crude ethanolic extract [61] , [62] but also as Homeopathic preparations 6c and 30c [63] . It has been suggested that T. chebula extract and other Indian plants with anticancer properties may act by enhancing Fenton reaction-mediated damage to deoxynucleoside triphosphates, thus slowing down DNA replication in rapidly dividing cancer cells [64] .…”

Section: Discussionmentioning

confidence: 99%

Experimental neuropharmacology of Gelsemium sempervirens : Recent advances and debated issues

Bellavite

Bonafini

Marzotto

2018

Journal of Ayurveda and Integrative Medicine

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Gelsemium sempervirens L. (Gelsemium) is traditionally used for its anxiolytic-like properties and its action mechanism in laboratory models are under scrutiny. Evidence from rodent models was reported suggesting the existence of a high sensitivity of central nervous system to anxiolytic power of Gelsemium extracts and Homeopathic dilutions. In vitro investigation of extremely low doses of this plant extract showed a modulation of gene expression of human neurocytes. These studies were criticized in a few commentaries, generated a debate in literature and were followed by further experimental studies from various laboratories. Toxic doses of Gelsemium cause neurological signs characterized by marked weakness and convulsions, while ultra-low doses or high Homeopathic dilutions counteract seizures induced by lithium and pilocarpine, decrease anxiety after stress and increases the anti-stress allopregnanolone hormone, through glycine receptors. Low (non-Homeopathic) doses of this plant or its alkaloids decrease neuropathic pain and c-Fos expression in mice brain and oxidative stress. Due to the complexity of the matter, several aspects deserve interpretation and the main controversial topics, with a focus on the issues of high dilution pharmacology, are discussed and clarified.

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“…Drug-DNA interaction was implicated in this phenomenon. Interestingly, recent studies showed existence of nanoparticlelike structures in some homeopathy formulations (239,(263)(264)(265). In this regard, it would be relevant to investigate anti-HPV effects and mechanism of action of these homeopathic drugs.…”

Section: Anti-hpv Leads In Alternative Medicinesmentioning

confidence: 99%

Therapeutic startegies for human papillomavirus infection and associated cancers

et al. 2018

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Human papillomavirus (HPV) infection is linked to development of cancer of cervix, vagina, vulva, penis, ano-genital and non-genital oro-pharyngeal sites. HPV being a sexually transmitted virus infects both genders equally but with higher chances of pathological outcome in women. In the absence of organized screening programs, women report HPV-infected lesions at relatively advanced stages where they are subjected to standard treatments that are not HPV-specific. HPV infection-driven lesions usually take 10-20 years for malignant progression and are preceded by well-characterized pre-cancer stages. Despite availability of window for pharmacological intervention, therapeutic that could eradicate HPV from infected lesions is currently lacking. A variety of experimental approaches have been made to address this lacuna and there has been significant progress in a number of lead molecules which are in different stages of clinical and pre-clinical development. Present review provides a brief overview of the magnitude of the problem and current status of research on promising lead molecules, formulations and therapeutic strategies that showed potential to translate to clinically-viable HPV therapeutics to counteract this reproductive health challenge.

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Evaluating the anticancer activity and nanoparticulate nature of homeopathic preparations of Terminalia chebula

Cited by 25 publications

References 28 publications

Homeopathy in Experimental Cancer Models: A Systematic Review

Homeopathy in Experimental Cancer Models: A Systematic Review

Experimental neuropharmacology of Gelsemium sempervirens : Recent advances and debated issues

Therapeutic startegies for human papillomavirus infection and associated cancers

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