Evaluating subjective domains of antipsychotic‐induced adverse effects using heart rate variability

Chang, Jae Seung; Hwang, Sung Hwan; Yi, Sang Hoon; Kim, Yeni; Lee, Yu-Sang; Kim, Yong Sik; Jung, Hee Yeon

doi:10.1111/pcn.12226

Cited by 3 publications

(2 citation statements)

References 49 publications

(101 reference statements)

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“…However, this relationship has not been fully studied and some studies has conflicting results [1,2]. Several studies found more excess cardiovascular dysfunction in Schizophrenia patients than in control [3,4], and cardiac failure including suicidal action [5]. Recent attention has focused on the ISSN: 2332-3469 length is varied using frequency generator and the light indicator automatically divides the cycle length into 40% inhalation and 60% exhalation [8].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Autonomic Function in Patients with Schizophrenia Using Spectral Analysis and Approximate Entropy Method

2016

J Neurol Psychol

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Objective: Autonomic nervous system involvement in patients with Schizophrenia has rarely been studied and has shown conflicting results. Our main purpose was to demonstrate that the Schizophrenia patients have malfunction in autonomic function compared with another group of normal control subjects by using power spectra of Heart Rate Variability (extracted from ECG) and measuring the frequency gain response of the two groups. Other purpose of this study was to determine wither the duration of Schizophrenia affect of function of Autonomic nervous system using the nonlinear method approximate entropy index (ApEn).Methods: Fifty two patients with Schizophrenia and fifty one matched healthy subjects were evaluated at Neurology Center, Johns Hopkins Hospital, Maryland, USA during 2013/ 2014 by measuring the breathing at different rates and HRV signal derived from Electrocardiogram (ECG). The auto-power and cross power spectra between HRV signal and breathing signal at different breathing rate were calculated and frequency gain response for both groups were obtained. ApEn described as measure of regularity of HRV was calculated for both patients with Schizophrenia and healthy control subjects.Results: Both frequency gain response and ApEn measure were reduced in patients with Schizophrenia in comparison with control group. The power spectra of patients with Schizophrenia showed reduced High Frequency (HF) value and higher low frequency with respect to control subjects. On other hand, ApEn measure was significantly reduced in longer Schizophrenia duration in Patients with Schizophrenia. Conclusion:These findings suggest that the spectral analysis of HRV signal using breathing at different frequencies may detect unbalance of autonomic of autonomic system of patients with Schizophrenia specially with increasing the sympathetic activity (higher low frequency) and reducing the parasympathetic tone (reduced frequency gain response) which indicate malfunction of autonomic function (Deficit) in patients with Schizophrenia. ApEn may be used as marker for screening Schizophrenia patients for the assessment of function of autonomic nervous system related to the duration of the disease.

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Section: Introductionmentioning

confidence: 99%

Assessment of Autonomic Function in Patients with Schizophrenia Using Spectral Analysis and Approximate Entropy Method

2016

J Neurol Psychol

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“…Others have shown that people with schizophrenia have decreased HRV compared to the general population (J. S. Chang et al, 2009;Clamor et al, 2016;Liu et al, 2021;Montaquila et al, 2015;Quintana et al, 2016). Moreover, decreased HRV has been associated with greater likelihood of negative symptoms (J. S. Kim et al, 2004), and general psychopathology symptoms (Benjamin et al, 2020;J. S. Chang et al, 2015) as rated on the PANSS.…”

Section: Bridging Cardiac Dysfunction With the Brain And Outcomementioning

confidence: 99%

Cardiac Dysfunction in People with Schizophrenia: Linking Clinical Outcome, the Heart, and the Brain

Nyveld¹

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While cardiovascular disease remains the primary cause of mortality in people with schizophrenia, the link between cardiac dysfunction and clinical outcome remains poorly understood. The current study is an exploratory analysis, where a total of thirteen participants with schizophrenia were included to examine clinical outcome, cardiac structure and function, and brain volume of the anterior cingulate cortex (ACC) as measured by magnetic resonance imaging, where those participants achieving remission (N = 7) had better global functioning, with fewer positive and negative symptoms on PANSS and SNS. Cardiac function and structure did not differ between remitted and non-remitted groups; but, those not in remission had significantly less volume in the left ACC. As a whole sample, no significant relationships were found between ACC volume and clinical symptoms; however, inverse relationships between social withdrawal and left ventricular end diastolic volume (LVEDV), left ventricular end systolic volume (LVESV), left ventricle stroke volume (LVSV), left-ventricular concentricity (a ratio of left ventricular EDV/mass), and right ventricular end systolic volume (RVESV) were observed. Moreover, bilateral ACC volume was significantly correlated with higher LVEDV, LVSV, RVSV, and lower LV Concentricity, whereas only the left ACC was significantly related to higher RVEDV. Of note, all participants had significantly increased left ventricular concentricity compared to the general population. These results support that clinical outcome is indeed related to brain volume but may not be related to cardiac measures of function and structure in people with schizophrenia, but more research is required to verify these conclusions and to further explore the mechanisms of cardiac dysfunction.

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Parasympathetic activity as a potential biomarker of negative symptoms in patients with schizophrenia

Huang

Liu

Chen

et al. 2020

Asia-Pacific Psychiatry

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IntroductionAutonomic dysfunction in patients with schizophrenia has raised concern considering the higher cardiovascular mortality and morbidity rate. This phenomenon has been demonstrated using various measurements and is inferred to be associated with demographics, medical treatment, and psychopathology. However, few have targeted the role of negative symptoms within schizophrenia.MethodsSchizophrenia patients with stationary psychopathology were recruited from a chronic ward, a daycare center, and a nonintensive case management program. Demographic data, medication history, the Positive and Negative Syndrome Scale (PANSS) score, the Personal and Social Performance Scale (PSP) score, and the five‐minute resting‐state heart rate variability (HRV) were collected at trial initiation (Time 1) and a year later (Time 2). The relationships between variables and HRV indices were evaluated using correlation and regression analyses.ResultsA total of 63 participants were recruited at Time 1, with 29 participants remaining at Time 2. Correlation analyses showed a negative correlation between the PANSS negative score (PANSS‐N) and total power (TP), low‐frequency power (LF), and high‐frequency power (HF) at Time 1. The results were further examined with multiple linear regression analysis and remained significant between the PANSS‐N score and HF (β = −0.306, P = .012). A generalized estimating equation model revealed the above negative association to be significant considering both timepoints.DiscussionThe negative association between negative symptom severity and parasympathetic activity was significant, which may inspire further research into the corresponding treatment, the mechanisms, and the use of HRV as an applicable biomarker for treatment response.

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Evaluating subjective domains of antipsychotic‐induced adverse effects using heart rate variability

Cited by 3 publications

References 49 publications

Assessment of Autonomic Function in Patients with Schizophrenia Using Spectral Analysis and Approximate Entropy Method

Assessment of Autonomic Function in Patients with Schizophrenia Using Spectral Analysis and Approximate Entropy Method

Cardiac Dysfunction in People with Schizophrenia: Linking Clinical Outcome, the Heart, and the Brain

Parasympathetic activity as a potential biomarker of negative symptoms in patients with schizophrenia

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