Evaluating Sleep and Cognition in HIV

Gamaldo, Charlene E.; Gamaldo, Alyssa A.; Creighton, Jason; Salas, Rachel E.; Selnes, Ola A.; David, Paula; Mbeo, Gilbert; Parker, Benjamin S.; Brown, Amanda; McArthur, Justin C.; Smith, Michael T.

doi:10.1097/qai.0b013e31829d63ab

Cited by 54 publications

(50 citation statements)

References 46 publications

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“…It can be associated with lack of attention, concentration, fatigue, memory/mood swings, and reduction in energy levels [14,15]. It may also increase the risk of cardiovascular morbidity and mortality, and psychiatric disorders with effects on health care utilization [16]. HIV individuals with sleep problems are less likely to adhere to their antiretroviral therapy regimens as reported in some studies, probably as a result of depression [17,18].…”

Section: Introductionmentioning

confidence: 99%

Predictors of Sleep Disorders among HIV Out-Patients in a Tertiary Hospital

Bisong¹,

Williams²,

Okpa³

et al. 2017

Recent Advances in Biology and Medicine

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Human immunodeficiency virus (HIV)-infected individuals have been shown to have a high prevalence of sleep disturbances. Both the effects of the virus and the antiretroviral drugs may cause sleep disturbances. We sought to determine the prevalence and predictors of sleep disorders among HIV seropositive adult subjects presenting at an outpatient hospital setting. One hundred and fifty six subjects were recruited for the study by using a sleep disorder screening questionnaire. The mean ages of the participants were 38.7 6 9.23 and 39.5 6 9.23 for those with and those without sleep disorder, respectively. The prevalence rate of sleep disorders was 46.2%. Elevated systolic blood pressure, lower CD4 count levels, and being on the highly active antiretroviral therapy combination TDF/3TC/ATZ/lpvr were associated with sleep disorders. The high prevalence rate observed necessitates routine screening for sleep disorders among HIV/AIDs patients.

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Section: Introductionmentioning

confidence: 99%

Predictors of Sleep Disorders among HIV Out-Patients in a Tertiary Hospital

Bisong¹,

Williams²,

Okpa³

et al. 2017

Recent Advances in Biology and Medicine

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“…In the HIV population, anxiety regarding a potential fatal illness, financial concerns, stigmatization, depression, and unemployment are frequent and can interfere with physical, mental, and emotional functioning and consequently affect the quality of sleep [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Risk Factors of Sleep Disturbance in a Large HIV-Infected Adult Population

Allavena

Guimard²,

Billaud

et al. 2015

AIDS Behav

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This cross-sectional study evaluates the prevalence and factors associated with sleep disturbances in French adult HIV-infected outpatients. Patients fullfilled a self-administered questionnaire on their health behavior, sleep attitudes (Pittsburgh sleep quality index, PSQI), quality of life and depression; 1354 patients were enrolled. Median sleeping time was 7 h. Poor sleep quality was observed in 47 % of the patients, and moderate to serious depressive symptoms in 19.7 %. Factors significantly associated with sleep disturbances were depression, male gender, active employment, living single, tobacco-smoking, duration of HIV infection, nevirapine or efavirenz-including regimen. Prevalence of poor sleepers is high in this HIV adult outpatient population. Associated factors seem poorly specific to HIV infection and more related to social and psychological status. Taking care of these disturbances may prove to be an effective health management strategy.

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“…The most common type of sleep problem in HIV disease is difficulty with sleep maintenance (Phillips et al, 2005; Lee et al, 2012; Gamaldo et al, 2013b), although short sleep duration (Lee et al, 2012; Gamaldo et al, 2013a) and disturbed sleep-wake rhythm (Taibi et al, 2013) are also reported. Sleep problems can be influenced by mood disorders, lifestyle factors, and HIV disease processes and treatments.…”

Section: Introductionmentioning

confidence: 99%

Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV

Lee

Byun

Lerdal

et al. 2015

Chronobiology International

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Genes involved in circadian regulation, such as circadian locomotor output cycles kaput [CLOCK], cryptochrome [CRY1], and period [PER], have been associated with sleep outcomes in prior animal and human research. However, it is unclear whether polymorphisms in these genes are associated with the sleep disturbances commonly experienced by adults living with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Thus, the purpose of this study was to describe polymorphisms in selected circadian genes that are associated with sleep duration or disruption as well as the sleep-wake rhythm strength and phase timing among adults living with HIV/AIDS. A convenience sample of 289 adults with HIV/AIDS was recruited from HIV clinics and community sites in the San Francisco Bay Area. A wrist actigraph was worn for 72 hours on weekdays to estimate sleep duration or total sleep time (TST), sleep disruption or percentage of wake after sleep onset (WASO), and several circadian rhythm parameters: mesor, amplitude, the ratio of mesor to amplitude (circadian quotient), and 24-hour autocorrelation. Circadian phase measures included clock time for peak activity (acrophase) from actigraphy movement data, and bed time and final wake time from actigraphy and self-report. Genotyping was conducted for polymorphisms in 5 candidate genes involved in circadian regulation: CLOCK, CRY1, PER1, PER2, and PER3. Demographic and clinical variables were evaluated as potential covariates. Interactions between genotype and HIV variables (i.e., viral load, years since HIV diagnosis) were also evaluated. Controlling for potentially confounding variables (e.g., race, gender, CD4+ T-cell count, waist circumference, medication use, smoking, depressive symptoms), CLOCK was associated with WASO, 24-hour autocorrelation, and objectively-measured bed time; CRY1 was associated with circadian quotient; PER1 was associated with mesor and self-reported habitual wake time; PER2 was associated with TST, mesor, circadian quotient, 24-hour autocorrelation, and bed and wake times; PER3 was associated with amplitude, 24-hour autocorrelation, acrophase, and bed and wake times. Most of the observed associations involved a significant interaction between genotype and HIV. In this chronic illness population, polymorphisms in several circadian genes were associated with measures of sleep disruption and timing. These findings extend the evidence for an association between genetic variability in circadian regulation and sleep outcomes to include the sleep-wake patterns experienced by adults living with HIV/AIDS. These results provide direction for future intervention research related to circadian sleep-wake behavior patterns.

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Evaluating Sleep and Cognition in HIV

Cited by 54 publications

References 46 publications

Predictors of Sleep Disorders among HIV Out-Patients in a Tertiary Hospital

Predictors of Sleep Disorders among HIV Out-Patients in a Tertiary Hospital

Prevalence and Risk Factors of Sleep Disturbance in a Large HIV-Infected Adult Population

Circadian regulation gene polymorphisms are associated with sleep disruption and duration, and circadian phase and rhythm in adults with HIV

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