Evaluating S100B as a serum biomarker for central neurosarcoidosis

Moss, Brandon P; Patel, D.C.; Tavee, Jinny; Culver, Daniel A.

doi:10.1016/j.rmed.2019.105855

Cited by 14 publications

(10 citation statements)

References 7 publications

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“…Different biomarkers have been studied in NS, e.g., angiotensin-converting enzyme [16,17], soluble interleukin-2 receptor (sIL-2R) [7,18], interleukin-6 (IL-6), interleukin-10 [6], and S100B [8,19]. sIL-2R, IL-6, and S100B have all been shown to be elevated in NS, but sIL-2R and IL-6 are non-specific, and S100B is not exclusively associated with neural cells [19].…”

Section: Discussionmentioning

confidence: 99%

“…The MRI was graded by the number of affected anatomical sites visualised by post-contrast enhanced lesions. Supratentorial meningeal enhancement, infratentorial meningeal enhancement, parenchymal enhancement, and enhancing lesions in the cervical spine, thoracic spine, lumbar spine, or cauda equina all give one point each [8]. A score of 0 points was graded no enhancement, 1-2 points were graded mild enhancement, and a score of 3-6 points was graded moderate/severe enhancement.…”

Section: Data Validationmentioning

confidence: 99%

“…Diagnosing NS is challenging as clinical symptoms may not reflect disease activity. Magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) findings are frequently non-specific [4,5], and only a few biomarkers have been investigated so far [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis

et al. 2021

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Background: Damage to axonal cells releases neurofilament light chain (NFL) into the cerebrospinal fluid and plasma. The objective of this study was to investigate NFL as a potential biomarker of disease activity in neurosarcoidosis. MRIs were graded according to enhancing lesions at different central nervous system (CNS) sites. Results: In cerebrospinal fluid, levels of NFL were higher in neurosarcoidosis patients (n = 20) median 2304 pg/mL (interquartile range (IQR) 630–19,612) compared to 426 pg/mL (IQR 261-571) in extra-neurologic sarcoidosis patients (n = 20) and 336 pg/mL (IQR 194–402) in healthy controls (n = 11) (p = 0.0002). In plasma, levels of NFL were higher in neurosarcoidosis patients median 28.2 pg/mL (IQR 11.5–49.3) compared to 6.2 pg/mL (IQR 4.3–8.2) in extra-neurologic sarcoidosis patients and 7.1 pg/mL (IQR 6.2–9.0) in healthy controls (p = 0.0001). Levels in both cerebrospinal fluid and plasma were higher in neurosarcoidosis patients with moderate/severe enhancement than patients with mild enhancement on MRI (p = 0.009 and p = 0.005, respectively). To distinguish neurosarcoidosis patients from extra-neurologic patients and healthy controls, a cut-off level of 630 pg/mL in cerebrospinal fluid had 94% specificity and 79% sensitivity, while a cut-off level of 11.4 pg/mL in plasma had 97% specificity and 75% sensitivity. Conclusions: NFL levels in cerebrospinal fluid and plasma are significantly higher in neurosarcoidosis patients compared to extra-neurologic patients and healthy controls, and the levels correlate to the extent of inflammation on MRI.

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Section: Discussionmentioning

confidence: 99%

Section: Data Validationmentioning

confidence: 99%

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Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis

et al. 2021

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“…S100B encodes a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. Serum S100B protein has been used as an important biomarker of bipolar disorder 37 . Serum S100B protein's expression level was increased in patients with bipolar disorder 38 while decreased after treatment in bipolar patients in a manic phase 39 .…”

Section: Bipolar Disordermentioning

confidence: 99%

Systematic comparative analysis of Mendelian randomization methods for inferring causal genes of complex phenotypes and the application to psychiatric diseases

Jiang¹,

et al. 2020

Preprint

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Isolating causal genes from enormous genome-wide association signals of complex phenotypes remains an open and challenging question. SMR (Summary-based Mendelian Randomization) is a widely used Mendelian randomization (MR) method for inferring causal genes by using a single expression quantitative trait locus (eQTL). In the present study, we explored more powerful MR methods based on multiple eQTLs. Among six representative multiple instrumental variable (IVs) based MR methods, original used in the epidemiological field, not all MR methods worked for the causal gene estimation. But we found the maximum-likelihood based MR method and weighted median-based MR method were preferable to the other four MR methods in terms of valid type 1 errors, acceptable statistical powers and robustness to linkage disequilibrium (LD) in eQTLs. Both of the MR methods were also much more powerful than the SMR. We recalibrated key parameters of the two MR methods in practices and developed a multiple IVs based MR analysis framework for causal gene estimation, named MACG and available at http://pmglab.top/kggsee. In the applications, MACG not only rediscovered many known causal genes of the schizophrenia and bipolar disorder, but also reported plenty of promising candidate causal genes. In conclusion, this study provided a powerful tool and encouraging exemplars of mining potential causal genes from huge amounts of GWAS signals with eQTLs.

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“…Recently, important clinical findings Zhen Zheng, Peng Zheng have contributed equally to this report. indicated that peripheral blood S100B levels can rule out central nervous system damage which was measured by magnetic resonance imaging in patients (Moss et al 2020;Thompson et al 2016). Therefore, scientists assume that peripheral blood S100B levels may reflect the presence of neuropathological conditions (Hughes et al 2018;Shotar et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Zheng

Zou

2020

J Autism Dev Disord

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The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD) = 0.97, 95% confidence interval (95% CI) = 0.41–1.53; p < 0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD.

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Evaluating S100B as a serum biomarker for central neurosarcoidosis

Cited by 14 publications

References 7 publications

Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis

Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis

Systematic comparative analysis of Mendelian randomization methods for inferring causal genes of complex phenotypes and the application to psychiatric diseases

Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

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